Olfactory Neuroblastoma and Olfactory Ventricle

Abstract

A case of dumbbell nasal and intracerebral olfactory neuroblastoma (ONB) related to possible seeding through an “olfactory ventricle” in the olfactory bulb and nerve is reported. This anatomic variant was recognized at operation for the first time: it consists of a hollow cavity within the olfactory bulb and nerve which may be connected to the subventricular zone of the frontal horn of the lateral ventricle. Better scrutiny of this structure is necessary in view of its possible interference with the course and diffusion of ONBs.

Keywords

olfactory neuroblastoma olfactory ventricle cerebral hemorrhage stem cell subventricular zone

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References

Curtis

Kam

Nannmark

. Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension. Science. 2007; 315: 1243–1249. doi: 10.1126/science.1136281.

Dulguerov

Allal

Calcaterra

. Esthesioneuroblastoma: a meta-analysis and review. Lancet Oncol. 2001; 2 (11): 683–690. doi: 10.1016/S1470-2045(01)00558-7.

Kam

Curtis

McGlashan

: The cellular composition and morphological organization of the rostral migratory stream in the adult human brain. J Chem Neuroanat. 2009; 37 (3): 196–205. doi: 10.1016/j.jchemneu.2008.12.009.

Qui-Ones-Hinojosa

Chaichana

. The human subventricular zone: a source of new cells and a potential source of brain tumors. Exp Neurol. 2007; 205 (2): 313–324. doi: 10.1016/j.expneurol.2007.03.016.

Sampath

Park

Huang

. Esthesioneuroblastoma (olfactory neuroblastoma) with hemorrhage: an unusual presentation. Skull Base. 2006; 16 (3): 169–173. doi: 10.1055/s-2006-939677.

Sanai

Tramontin

Qui-Ones-Hinojosa

. Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration. Nature. 2004; 427 (6976): 740–744. doi: 10.1038/nature02301.

Sanai

Berger

Garcia-Verdugo

. Comment on “Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension”. Science. 2007: 318: 393b. doi: 10.1126/science. 1145011.

Smitka

Abolmaali

Witt

. Olfactory bulb ventricles as a frequent finding in magnetic resonance imaging studies of olfactory system. Neuroscience. 2009; 162: 482–485. doi: 10.1016/j.neuroscience.2009.04.058.