Low-Dose Granisetron for Postoperative Nausea and Vomiting Prophylaxis

Abstract

OBJECTIVE

To evaluate the use of low-dose granisetron in postoperative nausea and vomiting prophylaxis.

DATA SOURCES

Clinical trials available through PubMed and OVID (1966—July 2003), as well as information supplied by the drug manufacturer, were accessed.

DATA SYNTHESIS

Safety concerns associated with droperidol and limited availability of other agents have created a need to restructure prophylaxis guidelines for postoperative nausea and vomiting. It has recently been proposed that granisetron may be effective at a dose that is one-tenth of the Food and Drug Administration—approved dose. Conflicting evidence for this regimen is evaluated.

CONCLUSIONS

Based on the scarcity of supporting data, this regimen is not recommended for prophylaxis in patients at risk for postoperative nausea and vomiting.