KennedyGCMoosWH, eds. Genomics Research. Drug Dev Res1997;41: 111–217.
2.
The pharmaceutical industry. The Economist1998(February 21): 3–18.
3.
NicolaouKCXuJ-YKimSOshimaTHosokawaSPfefferkornJ. Synthesis of the tricyclic core of eleutherobin and sarcodictyins and total synthesis of sarcodictyin A. J Am Chem Soc1997;119: 11353–4.
4.
HolmesA. Ringing the changes. Nature1997;390: 560–1.
5.
NicolaouKCYangZShiG-QGunznerJLAgriosAGartnerP. Total synthesis of brevetoxin A. Nature1998;392: 264–9.
6.
TriggleDJ. Medicines development: The Garden of Eden and beyond. Herbal Medicines Symposium, ed. RoufogalisB, University of Sydney, Department of Pharmacy, Australia, November 1997, in press.
7.
DalyJWGarraffoHMMyersCW. The origin of frog skin alkaloids: An enigma. Pharm News1997;4: 9–14.
8.
HolladayAWWasicakJTLinN-HHeYRytherKBBannonAWIdentification and initial structure-activity relationships of i?-5-(2-azetidinylmethoxy)-2-chloropyridine (ABT 594), a potent, orally active, non-opiate analgesic acting via neuronal nicotinic receptors. J Med Chem1998;41:407–12.
9.
BullATGoodfellowMSlaterJH. Biodiversity is a source of innovation in biotechnology. Ann Rev Microbiol1992;46: 219–52.
10.
RiddleJMEstesJW. Oral contraceptives in ancient and medieval times. Am Sci1992;80: 226–33.
OliveraBMHillyardDRMarshMYoshikamiD. Combinatorial peptide libraries in drug design: Lessons from venomous cone snails. Trends Biotech1995;13: 422–6.
13.
KornishVWMendelDSchultzPG. Probing protein structure and function with an expanded genetic code. Angew Chem1995;34: 621–33.
14.
KhoslaCZawadaRJX. Generation of polyketide libraries in combinatorial biosynthesis. Trends Biotech1996;14: 137–42.
15.
RawlsRL. Modular enzymes. Chem Eng News1998;(March 9): 29–32.
16.
TjivikuaTBalletserPRebekJ. A self-replicating system. J Am Chem Soc1990;112: 1249–50.
17.
WintnerEAConnMMRebekJ. Studies in molecular evolution. Accts Chem Res1994;27: 198–203.
18.
LeeDHGranjaJRMartinezJASeverinKGhadiriMR. A self-replicating peptide. Nature1996;382: 525–8.
19.
SzostakJW. Evolution ex vivo. Nature1993;361: 119–20.
20.
TurekCGoldL. Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science1990;249: 505–10.
21.
BeaudryAJoyceGF. Directed evolution of an RNA enzyme. Science1992;257: 635–41.
22.
CulverKWRamZWallbridgeSIshiiHOldfieldEHBlaeseRM. In vivo gene transfer with retroviral vector—producer cells for treatment of experimental brain tumors. Science1992;256: 1550–2.
23.
NolanGP. Harnessing viral devices as pharmaceuticals: Fighting HIV-1's fire with fire. Cell1997;90: 821–4.
24.
SchnellMJJohnsonJEBuonocoreLRoseJK. Construction of a novel virus that targets HIV-1 infected cells and controls HIV-1 infection. Cell1997;90: 849–57.
25.
DrexlerKE. Molecular nanomachines. Annu Rev Biophys Biomol Struct1994;23: 377–405.
26.
LavalJ-MChopineauJThomasD. Nanotechnology: R&D challenges and opportunities for application in biotechnology. Trends Biotech1995;13: 474–81.