Ehlers-Danlos syndrome (EDS) comprises a group of generalised connective tissue disorders. Deficiency or alteration of the collagen present in the tissues results in some classic signs such as skin hyperextensibility, joint hypermobility, and vascular fragility. Multiple supernumerary teeth, congenitally missing teeth, and odontogenic keratocysts have been reported in some patients with EDS. To the author's knowledge, transposition of permanent canines has not previously been reported in any case of EDS. This case report presents the dental findings of a sporadic case of classic-type EDS in a 14-year-old Chinese male who had transposition of a permanent maxillary canine as well as the presence of two supernumerary premolars in the mandible.
GorlinRJ, CohenMM, HennekamRC.Syndromes of the Head and Neck. 4th ed. New York: Oxford University Press; 2001. p. 512–28.
2.
WenstrupR, De PaepeA.Ehlers-Danlos syndrome, classic type. In: PagonRA, BirdTC, DolanCR, StephensK, editors. GeneReviews [Internet]. Seattle, WA: University of Washington; 2007 [updated 2010]. Accessed (2011 Apr 28) at: www.ncbi.nlm.nih.gov/books/NBK1244/
3.
ShaferWG, HineMJ, LevyBM.A Textbook of Oral Pathology. 4th ed. Philadelphia: WB Saunders; 1983. p. 846–8.
4.
HallRK.Pediatric Orofacial Medicine and Pathology. London: Chapman & Hall; 1994. p. 243–4.
5.
PopeFM, KomorowskaA, LeeKW, SpeightP, ZorawskaH, RantaH, . Ehlers Danlos syndrome type I with novel dental features. J Oral Pathol Med.1992;21:418–21.
6.
CarrRJ, GreenDM.Multiple odontogenic keratocysts in a patient with type II (mitis) Ehlers-Danlos syndrome. Br J Oral Maxillofac Surg.1988;26:205–14.
7.
FerreiaO, CardosoC, CapelozzaA, YaeduR, da CostaA.Odontogenic keratocyst and multiple supernumerary teeth in a patient with Ehlers-Danlos syndrome–A case report and review of the literature. Quintessence Int.2008;39:251–6.
8.
ReichertS, RiemannD, PlaschkaB, MachullaH.Early-onset periodontitis in a patient with Ehlers-Danlos syndrome type III. Quintessence Int.1999;30:785–90.
9.
MelamedY, BarakaiG, FrydmanM.Multiple supernumerary teeth (MSNT) and Ehlers-Danlos syndrome (EDS): a case report. J Oral Pathol.1994;23:88–91.
10.
LetourneauY, PerusseR, BuithieuH.Oral manifestations of Ehlers-Danlos syndrome. J Can Dent Assoc.2001;67:330–4.
11.
HartsfieldJKJr, KousseffBG.Phenotypic overlap of Ehlers-Danlos syndrome type IV and VIII. Am J Med Genet.1990;37:465–70.
12.
OoshimaT, AbeK, KohnoH, IzumitaniA, SobueS.Oral manifestations of Ehlers-Danlos syndrome type VII: histological examination of a primary tooth. Pediatr Dent.1990;12:102–6.
13.
TanP, SongC, LalondeD.Ehlers-Danlos syndrome associated with cleft lip and palate. Can J Plast Surg.2009;17:e24–6.
14.
BondPJ, FriendGW, MeridithMW.Ehlers-Danlos syndrome identified from periodontal findings: case report. Pediatr Dent.1993;15:212–3.
15.
ElyNJ, SherriffM, CobourneMT.Dental transposition as a disorder of genetic origin. Eur J Orthod.2006;28:145–51.
16.
PapadopoulosM, ChatzoudiM, KaragiannisV.Assessment of characteristic features and dental anomalies accompanying tooth transposition: a meta-analysis. Am J Orthod Dentofacial Orthop.2009;136:308.e1–10.
