Twelve pregnant women, 8–16 weeks, affected by severe, refractory HG.
Methods
Assessment by two clinical score indexes: Pregnancy Unique Quantification of Emesis (PUQE) score and a Visual Analogue Scale (VAS) 5-item questionnaire, filled out daily, to detect subjective improvement or worsening of symptoms.
Main outcome measures
PUQE score and VAS score before and after transdermal clonidine treatment.
Results
We found substantial improvement of symptoms and severity score indexes after four and 14 days. The comparison of pretreatment and post-treatment scores shows a significant statistical difference P < 0.0001.
Conclusion
Transdermal clonidine may be considered as a treatment for resistant severe HG.
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