Unilateral Versus Bilateral Resistance Exercise in Postoperative Rehabilitation After ACL Reconstruction With Bone–Patellar Tendon–Bone Graft: A Randomized Controlled Trial

Abstract

Background:

Lower limb muscle strength symmetry has been suggested as an essential criterion for the safe return to sports after anterior cruciate ligament (ACL) reconstruction. Limited evidence is available regarding the most effective intervention to achieve symmetry after reconstruction with contralateral bone–patellar tendon–bone (BPTB) graft.

Purpose:

To verify whether unilateral isotonic resistance exercise is more effective than bilateral exercise for obtaining postoperative functional and muscular strength symmetry between the donor limb and reconstructed limb for patients who received BPTB graft.

Study Design:

Randomized controlled trial; Level of evidence, 1.

Methods:

A total of 88 patients were randomly divided into a control group (n = 44) and an intervention group (n = 44). All participants performed an 8-week exercise program starting at the beginning of the fourth postoperative month and were evaluated before and after the program. The control group performed bilateral exercises, and the intervention group performed unilateral exercises for the donor limb only (the limb with the greatest disability). The primary outcome was muscle strength (peak torque and hamstrings to quadriceps [H:Q] ratio), and the secondary outcomes were range of motion (ROM; goniometry), KT-1000 arthrometer side-to-side difference in anteroposterior knee laxity, and objective (single-leg hop test) and subjective (Lysholm score) functionality.

Results:

Both groups improved significantly from before to after the exercise program. The improvements were significantly greater in the intervention group regarding peak torque, H:Q ratio, flexion ROM, single-leg hop test, and Lysholm score in the donor limb (P < .001 for all), and the improvements were significantly greater in the control group regarding peak torque and single-leg hop test in the reconstructed limb (P < .001 for both). Comparison between the groups showed significantly increased symmetry regarding peak torque, H:Q ratio, and single-leg hop test in the intervention group compared with the control group (P < .001), with large effect sizes (>0.80) except for the H:Q ratio.

Conclusion:

Although postoperative, bilateral, isotonic resistance exercise provided better strength gains to the reconstructed limb, unilateral exercise was more effective in obtaining functional and muscle strength between-limb symmetry in patients who underwent ACL reconstruction with contralateral BPTB graft.

Registration:

Brazilian Registry of Clinical Trials (number RBR-22rnjh).

Keywords

anterior cruciate ligament resistance training athletic injuries knee injuries rehabilitation

Anterior cruciate ligament (ACL) injuries have been the subject of study since the ninth century.²⁴ The direct costs estimated for surgical and rehabilitative procedures reach $3 billion per year.³² ACL injury is a severe injury that can cause a series of physical, psychological, and economic sequelae for the patient.³ In sports, ACL injury can mean a premature decrease in performance or even the end of a career.²⁶

Few studies have assessed the progression of resistance exercise in the postoperative period of ACL reconstruction. In general, the literature has been limited to understanding the ideal time to introduce resistance exercise,^5,18,28,49 measuring the loads generated during movements, comparing open and closed kinetic chain exercises,^14,25,40 and analyzing the progression of sensorimotor training (neuromuscular training).⁴¹

Previous studies^6,30,36 demonstrated the clinical results of short- and medium-term recovery of patients who underwent ACL reconstruction with a contralateral bone–patellar tendon–bone (BPTB) graft and were rehabilitated under the same conditions as described by Shelbourne and Klotz.⁴⁵ The patients were satisfied with their function, but the isokinetic evaluation at multiple time points showed the presence of significant differences in muscle performance between each lower limb, of which the donor limb, (ie, the healthy limb), was shown to be more deficient.^6,30,36 Symmetry of muscle strength is thought to be an essential criterion for a safe return to sports.²¹ However, limited evidence is available regarding the most effective interventions to achieve symmetry. To the best of our knowledge, no randomized controlled trial has identified the best strategy for the progression of resistance exercise for obtaining limb symmetry (range of motion [ROM], joint stability, muscle strength, and functionality) for patients who undergo ACL reconstruction with contralateral BPTB graft. Answering this question will contribute to the establishment of a better approach for these patients, reducing treatment time and minimizing muscle imbalance when they resume their activities. Finding an effective way to obtain symmetry is not only relevant but a necessity for professionals and patients.^4,29,50

The aim of the present study was to evaluate the effectiveness of unilateral isotonic resistance exercise when compared with its bilateral counterpart for obtaining the highest level of symmetry in functional and muscle strength variables between the donor limb and the ACL-reconstructed limb starting from the fourth month of rehabilitation in patients who received contralateral BPTB graft. Our hypothesis was that the use of unilateral isotonic resistance exercise in the donor limb would be more effective than the bilateral form for obtaining the highest level of functional and muscular strength symmetry between the donor limb and the reconstructed limb.

Methods

Our institution approved the protocol for this randomized, parallel, prospective, single-blinded controlled trial, and all participants were volunteers and signed an informed consent form. The method used was registered on the Brazilian Registry of Clinical Trials platform (number RBR-22rnjh).

Patients

Patients were recruited at the Orthopedic Hospital and Specialized Medicine/FIFA Medical Centre of Excellence between 2018 and 2019. The present study was performed with patients who underwent ACL reconstruction surgery with a contralateral BPTB graft. Patients of both sexes and varying occupations, who had practiced physical activity regularly (at least 3 times per week), had experienced an acute, traumatic ACL injury, and had received the same treatment—based on the knee symmetry model described by Biggs et al⁹—were included in the study. The exclusion criteria were patients younger than 18 and older than 55 years (according to the age group with the highest prevalence of ACL injuries in Brazil³¹), professional athletes, patients who had undergone revision surgery, patients with a history of injuries and/or lower limb surgery, patients who had developed arthrofibrosis in the early postoperative period (according to the classification established by Shelbourne et al⁴³), patients who had heart disease, pregnant women, and nursing mothers.

Sample Size Calculation

The sample size was based on the main objective of verifying whether there was a difference between the treatment groups in the progression of peak torque symmetry from before the exercise program (preintervention) to after (postintervention). Therefore, the following parameters were considered: significance level α = 5% (bilateral), power of the 1– β test = 80%, and the expected relatively “moderate” difference in the change (from pre- to postintervention) of peak torque symmetry between groups, known as effect size (≍0.60). As established by Cohen,¹³ the minimum number of patients in each group was 44, totaling 88 patients equally divided into the control group (n = 44) and the intervention group (n = 44).

Initial Monitoring of Patients

The medical team referred patients with an ACL injury to the study while they were still in the preoperative phase, after they had been diagnosed, and the treatment under study had been defined as the primary option.

Preoperative rehabilitation aimed to control the inflammatory process, restore ROM, improve muscle performance and sensorimotor capacity, obtain a symmetrical gait cycle, and encourage effective adherence to treatment and intervention, so that patients could fully dedicate themselves to the different phases of recovery, thus achieving the expected results. The preoperative phase was concluded when the patients had no acute inflammatory signs, with restored ROM and muscle trophism (considering ≤1-cm difference in thigh circumference between the limbs)³⁶ and good neuromuscular control, were walking normally, and were fully motivated. The mean preoperative rehabilitation time was 4 weeks.

The postoperative phase began at the hospital during the hospitalization period. The main objectives of this phase were to control pain and hemarthrosis, restore ROM, start weightbearing as tolerated, introduce bike training, and start muscle strengthening exercises (initially in closed kinetic chain) along with sensorimotor progression. The limbs were differentiated in terms of objectives. In the donor limb, the aim was to stimulate the regeneration and development of the donor area, so that muscle performance could be restored. For the reconstructed limb, special emphasis was given to controlling hemarthrosis, reestablishing ROM, and stimulating graft maturation.⁹

Surgical Procedure

All surgeries were performed by the same medical team. The procedures were based on previous studies.^30,44,45 All approaches were performed using the anatomic technique, via the medial portal, simultaneously in both knees (receptor and donor). A tourniquet was also used on both knees.

Regarding the donor procedure, an incision was initially made in the medial paratendon with divulsion in planes. From the opening of the paratendon, markings were made on the patellar ligament 10 mm wide and on the patella and tibia 20 mm in length, and bone plugs 10 mm in depth were removed. After removal of the graft, the donor area was closed with No. 1.0 Vicryl suture, including sheath and tendon. The bone graft was then placed in the patellar defect (from the tibial tunnel of the recipient knee).

Arthroscopic portals were made in the recipient knee, followed by synovectomy with cleaning of the tibial and femoral footprint, following the pattern of arthroscopic surgery. The knee was then positioned on the surgical table at 120° of flexion. Using the medial portal, the surgeon made the femoral tunnel, located approximately between the anteromedial and posterolateral bands, a little more medial, trying to reproduce the anteromedial band. The surgeon created the tibial tunnel with the patient’s knee off the table and flexed to 90°, using a tibial guide. The tibial footprint is located in the medial region of the tibial plateau, with reference to the posterior edge of the anterior horn of the lateral meniscus. After the tunnels were measured, the graft was introduced with the patient’s knee flexed at 45° to 90° and was fixed to the femur with a CL BTB Endobutton (Smith & Nephew) and to the tibia with a bioabsorbable screw (Smith & Nephew) with the knee flexed at 0° to 20°. Finally, an intra-articular suction drain was placed, portals were sutured with No. 4-0 nylon thread, and the donor knee incision was sutured.

Randomization

This was a 2-parallel-group, randomized clinical trial with a 1:1 intervention allocation. The randomization of the patients was performed by a statistical researcher using the Random Allocation Software (Version 2.0, Mahmood Saghaei). The allocation groups were placed in 100 (to account for dropout) opaque, nontranslucent, numbered envelopes that were opened at the time the patients arrived for the beginning of the intervention; thus, these patients received envelopes that were opened when they showed up for the continuation of rehabilitation.

Intervention Group

Patients in the intervention group underwent an 8-week program of unilateral resistance exercises (only for the donor limb) (Figure 1), starting at the beginning of postoperative month 4, immediately after the preintervention evaluation. Patients in the control group underwent an 8-week program according to the conventional method of bilateral exercises where patients are exercising both lower limbs at the same time (Figure 2) (Video Supplement 1).

Figure 1.

Sequence of exercises performed by the intervention group: (A) lunge, (B) leg press, (C) terminal extension, (D) leg extension machine, and (E) straight leg raise.

Figure 2.

Sequence of exercises performed by the control group: (A) squat, (B) leg press, (C) terminal extension, (D) leg extension machine, and (E) straight leg raise.

A minimum of 2 treatment sessions per week were performed, representing a minimum interval of 48 hours between sessions. The exercise sequence included stimuli through closed kinetic chain as well as open kinetic chain movements. These sessions were performed based on the complexity of the motor movement and on the number of joints involved.

For both groups, the exercise sequence was preceded by a 15-minute warm-up on the bike. The sequence is described below and was adopted for all the prescriptions of resistance exercises in the course of the patient follow-up period.¹ During the intervention period, patients were recommended to perform only the proposed activities. The sequence of exercises for the intervention group were lunge (with the donor limb in front), leg press, terminal extension, leg extension machine, and straight leg raise. The exercises for the controls were similar but used both limbs (squatting, leg press, terminal extension [knee extension with low pulley], leg extension machine, and straight leg raise).

The sessions consisted of 3 sets of 12 repetitions for each exercise, with each repetition performed within 2 seconds in both the concentric and eccentric phases. The program progression was performed through load adjustment, with increments from 2% to 10% for the following session in which the individual was able to perform all the repetitions in all sets of a given exercise.¹

The initial workload was defined according to the repetition test proposed by Kraemer and Fleck,²⁷ which makes it possible to identify the appropriate overload for the specificity of the resistance exercise program without subjecting the locomotor apparatus to maximum contraction stress. The interval between the sets was 1 minute, whereas the interval between the exercises was 3 minutes. All resistance exercise sessions were preceded by a 5-minute warm-up period on an exercise bike with an intensity of 60% of the maximum heart rate reserve (monitored by an Onyx Nonin digital finger pulse oximeter; Nonin Medical Inc) estimated from the maximum heart rate predicted by age, as follows: {[(220– Age)– Resting Heart Rate] × 0.6} + Resting Heart Rate.¹ At the end of each session, stretching was performed for quadriceps, hamstrings, and triceps surae in three 30-second sets.¹⁷

Outcome Measures

All the patients were evaluated before (4 months after surgery) and after the 8-week exercise program (Video Supplement 2). The primary outcome was muscle strength (peak torque and hamstrings to quadriceps [H:Q] ratio), and the secondary outcomes were ROM, side-to-side difference in anteroposterior knee laxity, and objective and subjective functionality. The procedures were performed by a blinded independent evaluator not involved in the study and with no employment relationship with the institutions. The evaluator was a physical therapist with a background in functional and sports trauma and orthopaedic physiotherapy and experienced in the application of the criteria used. He was unaware of any information related to the objectives of the study, diagnosis of patients, and distribution of the sample. The physical therapist was previously trained to use the assessment tools.

Initially, identification and anamnesis were performed, including the recording of weight and height. Next, the physical examination was performed by measuring ROM, anteroposterior knee laxity, knee extensor and flexor muscle strength, and knee function. ROM was measured using goniometry, considering the flexion and hyperextension movements. Joint stability was assessed objectively using a KT-1000 arthrometer (MEDmetric). Muscle strength was assessed using the Biodex Multi-Joint System 4 Pro isokinetic dynamometer (Biodex Medical Systems).¹⁰ The patients performed 5 maximum concentric repetitions of knee extension and flexion at a speed of 60 deg/s. The last step was the assessment of functional capacity, performed objectively through the single-leg hop test and subjectively using the Lysholm score, an instrument translated into Portuguese and validated with measurement and reliability properties.³⁹ Table 1 presents all of the primary (peak torque and H:Q ratio) and secondary outcomes assessed, as well as the assessment methods.

Table 1

Evaluation Criteria to Analyze the Primary and Secondary Outcomes

Evaluated Items	Outcome	Methods Used	Evaluation Criteria
Muscle strength	Primary	Isokinetic dynamometry¹⁰	Peak torque at 60 deg/s and hamstrings to quadriceps ratio
Passive motion deficit	Secondary	Goniometry²	Range of flexion and hyperextension
Anteroposterior knee laxity	Secondary	KT-1000 arthrometer²	Side-to-side difference in anterior tibial translation
Objective functionality	Secondary	Single-leg hop test²	Distance and symmetry
Subjective functionality	Secondary	Lysholm score³⁹	Total score

Data Analysis

The descriptive data analysis is presented to provide an overview of the participants based on their general characteristics: identification and anamnesis data. Such data are presented as median ± standard deviation for continuous data and as frequency and percentage for categorical data. Numerical data were compared using the Mann-Whitney U test, whereas categorical data were compared using the chi-square or Fisher exact test.

The normality and homogeneity of data were analyzed using the Shapiro-Wilk and Levene tests, respectively. Data showing a normal distribution were compared using the t test for independent samples. For the remaining variables, the nonparametric Mann-Whitney U test was used. For intra- and intergroup comparison of variables that showed normal distribution, a mixed-model analysis of variance (repeated measures and 2 factors) was used. For the remaining variables, the nonparametric Mann-Whitney U test was used (the pre-to-post difference in both groups was verified, and an intergroup comparison of this difference was made). The effect size was interpreted as follows: 0.00-0.49 (small effect), 0.50-0.79 (medium effect), and >0.80 (large effect).¹⁵ The level of symmetry between the limbs was calculated based on the difference between the donor and reconstructed limbs. All statistical analyses were conducted using IBM SPSS Version 20.0 for Windows.

Results

The study sample consisted of 97 patients assigned to the intervention and control groups. During development of the activities, 9 patients did not complete their participation in the study: 2 because of pain in the donor area (control group), 4 because of withdrawal (3 from the intervention group and 1 from control group), and 3 for not complying with the proposed procedures (2 from the intervention group and 1 from the control group). The final study sample consisted of 88 patients (44 each in the control and intervention groups) (Figure 3).

Figure 3.

CONSORT (Consolidated Standards of Reporting Trials)³⁴ flowchart of the randomized controlled trial showing the phases covered by the 2 study groups.

The general baseline characteristics of the study cohort are shown in Table 2. In total, 59 men (67%) and 29 women (33%) participated. Male patients were predominant in both groups: The intervention group consisted of 28 men and 16 women, whereas the control group consisted of 31 men and 13 women. Table 3 shows a comparison between the groups before the intervention. A significant difference between groups was found for flexion ROM in the donor limb (P = .03).

Table 2

Comparison of Baseline Characteristics Between the Groups ^a

Variable	Intervention (n = 44)	Control (n = 44)	P
Sex			.49
Male	28 (63.6)	31 (70.5)
Female	16 (36.4)	13 (29.5)
Age, y	28.0 ± 9.48	29.0 ± 9.37	.62
Weight, kg	72.0 ± 9.30	69.5 ± 9.94	.53
Height, cm	172 ± 7.16	171 ± 6.51	.56
Body mass index, kg/m²	23.7 ± 9.33	23.5 ± 8.54	.64
Dominance			.13
Right	35 (79.5)	34 (77.3)
Left	6 (13.6)	10 (22.7)
Ambidextrous	3 (6.8)	0 (0)
Donor limb			.26
Right	31 (70.5)	26 (59.1)
Left	13 (29.5)	18 (40.9)
Reconstructed limb			.26
Right	13 (29.5)	18 (40.9)
Left	31 (70.5)	26 (59.1)

^a Data are reported as n (%) or median ± SD.

Table 3

Comparison Between Groups at the Preintervention Stage Concerning the Study Outcomes ^a

Variable	Intervention (n = 44)	Control (n = 44)	P
Muscle strength
Peak extension torque, Nċm (DL)	153.5 ± 48.04	152.8 ± 30.34	.81
Peak extension torque, Nċm (ACL)	179.3 ± 49.6	180.9 ± 36.9	.92
H:Q ratio, % (DL)	67.83 ± 5.93	68.43 ± 4.52	.26
H:Q ratio, % (ACL)	53.19 ± 4.52	51.69 ± 4.01	.10
Passive motion deficit, deg
Flexion (DL)	145.5 ± 3.26	147 ± 3.90	.03
Flexion (ACL)	143.1 ± 3.86	144.3 ± 4.37	.14
Hyperextension (DL)	6.18 ± 2.77	5.72 ± 2.13	.41
Hyperextension (ACL)	4.13 ± 2.51	4.09 ± 2.14	.89
Anteroposterior knee laxity, mm
KT-1000 SSD (DL)	4.95 ± 1.82	4.26 ± 1.14	.14
KT-1000 SSD (ACL)	5 ± 1.75	4.48 ± 1.04	.26
Functional tests
SLHT, cm (DL)	112.2 ± 30.69	120.9 ± 25.19	.15
SLHT, cm (ACL)	111.6 ± 34.37	113.6 ± 25.51	.76
Lysholm score (DL)	85.68 ± 5.58	87.5 ± 4.73	.11

^a Data are reported as median ± SD. Bolded P value indicates statistically significant difference (P < .05). ACL, anterior cruciate ligament–reconstructed limb; DL, donor limb; H:Q, hamstrings to quadriceps; SLHT, single-leg hop test; SSD, side-to-side difference.

Assessment of Primary and Secondary Outcomes Between Groups

After the intervention, significant differences were found between groups (Table 4). Flexion ROM, single-leg hop test performance, H:Q ratio, peak torque in the donor limb, and Lysholm score were better in the intervention group compared with the control group (P < .001 for all). The single-leg hop test and peak torque in the reconstructed limb were better in the control group compared with the intervention group (P < .001 for both). Large effect sizes (>0.80) were seen in the pre- to postintervention change for peak torque (donor and reconstructed limbs) and single-leg hop test values (donor limb).

Table 4

Intra- and Intergroup Comparison of the Study Outcomes ^a

	Preintervention		Postintervention		P
Variable	Intervention (n = 44)	Control (n = 44)	Intervention (n = 44)	Control (n = 44)	Within Group ^b	Between Groups	Effect Size ^c
Muscle strength
Peak extension torque, Nċm (DL)	153.5 ± 48.04	152.8 ± 30.34	173.9 ± 49.13	161.8 ± 30.15	—	<.001	0.866
Peak extension torque, Nċm (ACL)	179.3 ± 49.6	180.9 ± 36.9	183.7 ± 49.64	198.8 ± 37.11	—	<.001	0.942
H:Q ratio, % (DL)	67.83 ± 5.93	68.43 ± 4.52	58.78 ± 3.27	64.16 ± 3.73	—	<.001	0.494
H:Q ratio, % (ACL)	53.19 ± 4.52	51.69 ± 4.01	53.39 ± 2.16	51.39 ± 3.81	.908	.572	0.126
Passive motion deficit, deg
Flexion (DL)	145.5 ± 3.26	147 ± 3.90	146.5 ± 2.88	147 ± 3.67	—	<.001	0.280
Flexion (ACL)	143.1 ± 3.86	144.3 ± 4.37	145.7 ± 3	146.4 ± 3.63	—	.347	0.114
Hyperextension (DL)	6.18 ± 2.77	5.72 ± 2.13	6.78 ± 2.41	6.18 ± 1.85	—	.280	0.109
Hyperextension (ACL)	4.13 ± 2.51	4.09 ± 2.14	6.43 ± 2.31	5.77 ± 1.91	—	.083	0.208
Functional tests
SLHT, cm (DL)	112.2 ± 30.69	120.9 ± 25.19	119.7 ± 27.88	121.7 ± 24.59	<.001	<.001	1.34
SLHT, cm (ACL)	111.6 ± 34.37	113.6 ± 25.51	115.8 ± 30.95	129.1 ± 24.96	—	<.001	0.695
Lysholm score (DL)	85.68 ± 5.58	87.5 ± 4.73	96.16 ± 2.59	93.45 ± 2.8	—	<.001	0.511

^a Data are expressed as median ± SD. Bolded P values indicate statistically significant difference (P < .05). ACL, anterior cruciate ligament–reconstructed limb; DL, donor limb; H:Q, hamstrings to quadriceps; SLHT, single-leg hop test.

^b Dashes indicate not applicable.

^c 0.00-0.49 (small effect); 0.50-0.79 (medium effect); >0.80 (large effect).

Effectiveness of Unilateral Versus Bilateral Resistance Exercise in the Symmetry of Muscle Strength After ACL Reconstruction

Table 5 shows a comparison between groups for the level of symmetry between the donor and reconstructed limbs concerning the objective functionality and muscle strength criteria. Significant differences were found for all variables, with increased symmetry in the intervention group compared with the control group (P < .001 for all). Except for the H:Q ratio, the effect sizes were large (>0.80).

Table 5

Comparison of Intralimb Symmetry (Donor–Reconstructed Limb) Between Groups ^a

	Preintervention		Postintervention		P
Variable	Intervention (n = 44)	Control (n = 44)	Intervention (n = 44)	Control (n = 44)	Within Group	Between Group	Effect Size
Single-leg hop test	0.60 ± 15.51	7.32 ± 7.45	3.86 ± 9.28	7.40 ± 8.76	<.001	<.001	2.22
H:Q ratio	14.64 ± 7.29	16.74 ± 5.88	5.39 ± 3.69	12.77 ± 5.14	<.001	<.001	0.78
Peak torque	–25.73 ± 12.55	–28.13 ± 13.08	–9.82 ± 8.97	–36.98 ± 14.12	<.001	<.001	3.07

^a Data are expressed as median ± SD. Bolded P values indicate statistically significant difference (P < .05). H:Q, hamstrings to quadriceps.

Discussion

The aim of the current study was to evaluate the effectiveness of unilateral isotonic resistance exercise compared with its bilateral counterpart for obtaining the highest level of symmetry after ACL reconstruction with contralateral patellar ligament graft. Our results confirmed the initial hypothesis. The present study demonstrated, for the first time, the obtainment of a higher symmetry between limbs through unilateral exercise compared with bilateral exercises according to functional and muscle performance variables in patients undergoing contralateral BPTB graft.

Rehabilitation after ACL injury is widely studied, and several protocols are described in the literature.^16,20,44,46 The decreases in sensorimotor capacity and muscle performance are 2 of the main complications verified after ACL reconstruction.⁴¹ Levels of quadriceps strength asymmetry are associated with biomechanical alterations in functional tests and are considered risk factors for the development of osteoarthritis and injury recurrences.³⁸ Effective strategies to achieve symmetry through resistance exercise are still a subject of controversy and little scientific study.^18,28,49 Our results showed the superiority of unilateral exercise compared with bilateral exercise. The main hypotheses that indicate the inferiority of bilateral training are related to mechanical and/or neural mechanisms, such as antagonist coactivation, reduced stimulation of motor units and/or type II fibers, the differentiated neural recruitment due to the cross effect in the extrapyramidal system, fiber differences in the limbs, and the predominance of using one limb to the detriment of the other, resulting in less force production.^11,37

In contrast, the unilateral exercises, despite achieving better symmetry, resulted in a delay of strength recovery in the ACL-reconstructed leg, given that the protocol used in our investigation focuses on muscle development, mainly in the donor limb.

Previous studies in patients undergoing ACL reconstruction with contralateral limb graft harvest showed similar results. Gonzalo-Skok et al¹⁹ analyzed basketball players who were randomly assigned to perform unilateral or bilateral training over the course of 6 weeks. The authors found that both programs improved physical fitness tests. However, only the unilateral group experienced a reduction in asymmetry between the limbs and demonstrated better results in actions that required the application of unilateral force. In the same year, to compare the neuromuscular adaptations of unilateral and bilateral training for knee extensor muscles, Botton et al¹² submitted 43 healthy young women to a 12-week resistance exercise program. The isometric muscle strength test demonstrated a significant increase in the unilateral group compared with the bilateral group, which could also be observed in the muscles’ electrical activity. The authors concluded that if training aims to optimize the gain of force produced for each lower limb separately, unilateral training should be recommended.

Regarding knee injury, Welling et al⁵¹ compared the results of a progressive strength training program for amateur soccer players after ACL reconstruction versus the results for healthy individuals (also amateur soccer players), investigating the quadriceps and hamstrings strength recovery. The intervention group consisted of 38 players, whereas the control group (healthy individuals) had 30 players, matched by age. The training program included unilateral and bilateral exercises in open kinetic chain (extension and flexor chair) and closed kinetic chain (squat, deadlift, split squats, step-ups, and good mornings). Quadriceps and hamstrings muscle strength was measured 3 times during rehabilitation using a limb symmetry index >90% as a discharge criterion. The results showed that the intervention group did not have significant differences between the limbs 7 months after the ACL reconstruction compared with the dominant limb of the control group. Also, 65.8% of patients reached a limb symmetry index of >90% at 10 months after surgery.

Moreover, analysis of the patients’ final condition showed significant changes in the muscle H:Q ratio, with more symmetry in the unilateral group compared with the bilateral group. The use of unilateral exercises in the donor limb (intervention group) provided a greater gain in quadriceps muscle strength compared with the use of bilateral exercises (control group): Increased in strength in the reconstructed limb promoted higher asymmetry. In patients with ACL injuries, an increase in H:Q ratio is normal for 2 reasons: (1) increased hamstrings reflex activity due to the instability caused by ligament loss⁴⁸ and (2) quadriceps weakness, which is typical in this type of patient, both before and after surgery.^35,38 Such analysis (H:Q ratio) is an outcome widely used in rehabilitation programs to ensure functional ability of the knee and its muscle balance.⁴² The H:Q ratio has been demonstrated to be protective for graft rupture (ie, the higher the ratio, the lower the risk).⁴² This is likely because the hamstrings are agonists to the ACL and should be in good balance with the quadriceps (antagonists of the ACL). Thus, our results demonstrate the importance of the unilateral protocol in ACL rehabilitation. We found no differences regarding ligamentous laxity between the analyzed groups.

Limitations

Our study has some limitations. We are aware of other widely used surgical techniques that directly affect decision-making regarding the most effective method of implementing resistance exercise from the preoperative period until discharge. Also, we do not know how the patients will progress until the end of the first year, which is a critical period for the occurrence of new injuries and/or complications. Furthermore, the wide age range of the study volunteers should be considered, as the goals and course of postoperative rehabilitation are very different based on age. This study applies only to patients receiving contralateral BPTB graft and is probably not suitable for other graft options. Finally, future studies should investigate the possible role of single-leg exercises for both legs.

Aside from these limitations, our study is the first randomized controlled trial to find the best strategy (unilateral or bilateral) for using resistance exercise to achieve symmetry between the lower limbs. We reported data following the CONSORT (Consolidated Standards of Reporting Trials) recommendations,³⁴ we described the interventions following the recommendations of the Template for Intervention Description and Replication,^21,22 and we described the intervention exercises according to the recommendations of the Consensus on Exercise Reporting Template.⁴⁷

In clinical terms, the main point of this study was to confirm the use of unilateral exercise as an effective alternative for the recovery of symmetry in patients who have undergone ACL reconstruction. This is the main implication of the results, allowing professionals to start the rehabilitation protocol early and ensure a favorable outcome. However, it is still not known which strategy—unilateral, bilateral, or unilateral performed with both legs—is the best option for rehabilitation. Moreover, new strategies must be developed to enhance the benefits of unilateral exercise in this group. The current literature contains promising alternatives, such isoinertial exercise,⁸ the use of vascular occlusion methods,^7,23 and the improvement of sensorimotor exercises.³³ These are essential topics for further investigation.

Conclusion

Although bilateral isotonic resistance exercise provided better strength gains to the ACL-reconstructed limb, the unilateral protocol obtained the highest level of functional and muscle strength symmetry between the donor limb and ACL-reconstructed limb in the postoperative phase of patients who underwent ACL reconstruction with contralateral BPTB graft.

A Video Supplement for this article is available at http://journals.sagepub.com/doi/suppl/10.1177/23259671221088830.

Footnotes

Final revision submitted December 6, 2021; accepted December 15, 2021.

The authors have declared that there are no conflicts of interest in the authorship and publication of this contribution. AOSSM checks author disclosures against the Open Payments Database (OPD). AOSSM has not conducted an independent investigation on the OPD and disclaims any liability or responsibility relating thereto.

Ethical approval for this study was obtained from the Universidade Federal de São Paulo (ref No. 60929).

References

American College of Sports Medicine. American College of Sports Medicine position stand. Progression models in resistance training for healthy adults. Med Sci Sports Exerc. 2009;41(3):687–708.

Anderson

Irrgang

Kocher

Mann

Harrast

; International Knee Documentation Committee. The International Knee Documentation Committee Subjective Knee Evaluation Form: normative data. Am J Sports Med. 2006;34(1):128–135.

Ardern

Bizzini

Bahr

. It is time for consensus on return to play after injury: five key questions. Br J Sports Med. 2016;50(9):506–508.

Ardern

Taylor

Feller

Webster

. Fifty-five per cent return to competitive sport following anterior cruciate ligament reconstruction surgery: an updated systematic review and meta-analysis including aspects of physical functioning and contextual factors. Br J Sports Med. 2014;48(21):1543–1552.

Arnold

Shelbourne

. A perioperative rehabilitation program for anterior cruciate ligament surgery. Phys Sportsmed. 2000;28(1):31–44.

Ataides

Oliveira

Lobo Júnior

, et al. Clinical results and functional surgery: the ACL reconstruction contralateral in medium term. Universitas: Ciências da Saúde. 2013;11(1):19–28.

Barber-Westin

Noyes

. Blood flow-restricted training for lower extremity muscle weakness due to knee pathology: a systematic review. Sports Health. 2019;11(1):69–83.

Beato

Dello Iacono

. Implementing flywheel (isoinertial) exercise in strength training: current evidence, practical recommendations, and future directions. Front Physiol. 2020;11:569.

Biggs

Jenkins

Urch

Shelbourne

. Rehabilitation for patients following ACL reconstruction: a knee symmetry model. N Am J Sports Phys Ther. 2009;4(1):2–12.

10.

Biodex Medical Systems. Instructions for use. Published 1998. Accessed July 1, 2020. https://www.biodex.com/physical-medicine/products/dynamometers/system-4-pro

11.

Botton

Pinto

. Bilateral deficit: origins, mechanisms, and implications for strength training. Rev Bras Cineantropom Desempenho Hum. 2012;14(6):749–761.

12.

Botton

Radaelli

Wilhelm

Rech

Brown

Pinto

. Neuromuscular adaptations to unilateral vs. bilateral strength training in women. J Strength Cond Res. 2016;30(7):1924–1932.

13.

Cohen

. Statistical Power Analysis for the Behavioral Sciences. 2nd ed. Lawrence Erlbaum; 1988.

14.

Escamilla

Macleod

Wilk

Paulos

Andrews

. Anterior cruciate ligament strain and tensile forces for weight-bearing and non-weight-bearing exercises: a guide to exercise selection. J Orthop Sports Phys Ther. 2012;42(3):208–220.

15.

Fritz

Morris

Richler

. Effect size estimates: current use, calculations, and interpretation [published correction appears in J Exp Psychol Gen. 2012;141(1):30]. J Exp Psychol Gen. 2012;141(1):2–18.

16.

Shen

Starman

Okeke

Irrgang

. Primary anatomic double-bundle anterior cruciate ligament reconstruction: a preliminary 2-year prospective study. Am J Sports Med. 2008;36(7):1263–1274.

17.

Garber

Blissmer

Deschenes

, et al. American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Med Sci Sports Exerc. 2011;43(7):1334–1359.

18.

Gerber

Marcus

Dibble

Greis

Burks

LaStayo

. Effects of early progressive eccentric exercise on muscle size and function after anterior cruciate ligament reconstruction: a 1-year follow-up study of a randomized clinical trial. Phys Ther. 2009;89(1):51–59.

19.

Gonzalo-Skok

Tous-Fajardo

Arjol-Serrano

Suarez-Arrones

Casajús

Mendez-Villanueva

. Improvement of repeated-sprint ability and horizontal-jumping performance in elite young basketball players with low-volume repeated-maximal-power training. Int J Sports Physiol Perform. 2016;11(4):464–473.

20.

Grindem

Granan

Risberg

Engebretsen

Snyder-Mackler

Eitzen

. How does a combined preoperative and postoperative rehabilitation programme influence the outcome of ACL reconstruction 2 years after surgery? A comparison between patients in the Delaware-Oslo ACL Cohort and the Norwegian National Knee Ligament Registry. Br J Sports Med. 2015;49(6):385–389.

21.

Grindem

Snyder-Mackler

Moksnes

Engebretsen

Risberg

. Simple decision rules can reduce reinjury risk by 84% after ACL reconstruction: the Delaware-Oslo ACL cohort study. Br J Sports Med. 2016;50(13):804–808.

22.

Hoffmann

Glasziou

Boutron

, et al. Better reporting of interventions: template for intervention description and replication (TIDieR) checklist and guide. BMJ. 2014;348:1687.

23.

Hughes

Paton

Rosenblatt

Gissane

Patterson

. Blood flow restriction training in clinical musculoskeletal rehabilitation: a systematic review and meta-analysis. Br J Sports Med. 2017;51(13):1003–1011.

24.

Jensen

Slocum

Larson

James

Singer

. Reconstruction procedures for anterior cruciate ligament insufficiency: a computer analysis of clinical results. Am J Sports Med. 1983;11(4):240–248.

25.

Jewiss

Ostman

Smart

. Open versus closed kinetic chain exercises following an anterior cruciate ligament reconstruction: a systematic review and meta-analysis. J Sports Med (Hindawi Publ Corp). 2017;2017:4721548.

26.

Kester

Behery

Minhas

Hsu

. Athletic performance and career longevity following anterior cruciate ligament reconstruction in the National Basketball Association. Knee Surg Sports Traumatol Arthrosc. 2017;25(10):3031–3037.

27.

Kraemer

Fleck

. Optimizing Strength Training: Designing Nonlinear Periodization Workouts. Human Kinetics ; 2007.

28.

Kristensen

Franklyn-Miller

. Resistance training in musculoskeletal rehabilitation: a systematic review. Br J Sports Med. 2012;46(10):719–726.

29.

Lai

CCH

Ardern

Feller

Webster

. Eighty-three per cent of elite athletes return to preinjury sport after anterior cruciate ligament reconstruction: a systematic review with meta-analysis of return to sport rates, graft rupture rates and performance outcomes. Br J Sports Med. 2018;52(2):128–138.

30.

Lobo Junior

Neto

Borges

JHS

Dias

LJRV

Machado

Freitas

. Contralateral patellar tendon autograft in anterior cruciate ligament reconstruction. Acta Ortop Bras. 2018;26(2):140–144.

31.

Lopes

TJA

Simic

Pappas

. Epidemiology of anterior cruciate ligament reconstruction in Brazil’s public. Rev Bras Med Esporte. 2016;22(4):297–301.

32.

Mall

Chalmers

Moric

, et al. Incidence and trends of anterior cruciate ligament reconstruction in the United States. Am J Sports Med. 2014;42(10):2363–2370.

33.

Meyer

Yamato

Saragiotto

. Knee injury and ACL tear prevention programmes (PEDro synthesis). Br J Sports Med. 2017;51(15):1161–1162.

34.

Moher

Schulz

Altman

; CONSORT Group (Consolidated Standards of Reporting Trials). The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomized trials. JAMA. 2001;285(15):1987–1991.

35.

Øiestad

Juhl

Eitzen

Thorlund

. Knee extensor muscle weakness is a risk factor for development of knee osteoarthritis: a systematic review and meta-analysis. Osteoarthritis Cartilage. 2015;23(2):171–177.

36.

Oliveira

Lobo

Oliveira

, et al. Resultados em curto prazo de reabilitação após cirurgia de reconstrução de ligamento cruzado anterior utilizando-se enxerto de tendão patelar contralateral. Universitas: Ciências da Saúde. 2014;12(1):29–35.

37.

Owings

Grabiner

. Normally aging older adults demonstrate the bilateral deficit during ramp and hold contractions. J Gerontol A Biol Sci Med Sci. 1998;53(6):B425–B429.

38.

Palmieri-Smith

Lepley

. Quadriceps strength asymmetry after anterior cruciate ligament reconstruction alters knee joint biomechanics and functional performance at time of return to activity. Am J Sports Med. 2015;43(7):1662–1669.

39.

Peccin

Ciconelli

Cohen

. Specific questionnaire for knee symptoms—the “Lysholm Knee Scoring Scale”—translation and validation into Portuguese. Acta Ortop Bras. 2006;14(5):268–272.

40.

Perriman

Leahy

Semciw

. The effect of open- versus closed-kinetic-chain exercises on anterior tibial laxity, strength, and function following anterior cruciate ligament reconstruction: a systematic review and meta-analysis. J Orthop Sports Phys Ther. 2018;48(7):552–566.

41.

Risberg

Holm

Myklebust

Engebretsen

. Neuromuscular training versus strength training during first 6 months after anterior cruciate ligament reconstruction: a randomized clinical trial. Phys Ther. 2007;87(6):737–750.

42.

Rosene

Fogarty

Mahaffey

. Isokinetic hamstrings: quadriceps ratios in intercollegiate athletes. J Athl Train. 2001;36(4):378–383.

43.

Shelbourne

Patel

Martini

. Classification and management of arthrofibrosis of the knee after anterior cruciate ligament reconstruction. Am J Sports Med. 1996;24(6): 857–862.

44.

Shelbourne

Gray

. Anterior cruciate ligament reconstruction with autogenous patellar tendon graft followed by accelerated rehabilitation: a two- to nine-year follow-up. Am J Sports Med. 1997;25(6):786–795.

45.

Shelbourne

Klotz

. What I have learned about the ACL: utilizing a progressive rehabilitation scheme to achieve total knee symmetry after anterior cruciate ligament reconstruction. J Orthop Sci. 2006;11(3):318–325.

46.

Shelbourne

Beck

Gray

. Anterior cruciate ligament reconstruction with contralateral autogenous patellar tendon graft: evaluation of donor site strength and subjective results. Am J Sports Med. 2015;43(3):648–653.

47.

Slade

Dionne

Underwood

Buchbinder

. Consensus on Exercise Reporting Template (CERT): explanation and elaboration statement. Br J Sports Med. 2016;50(23):1428–1437.

48.

Tsuda

Okamura

Otsuka

Komatsu

Tokuya

. Direct evidence of the anterior cruciate ligament-hamstring reflex arc in humans. Am J Sports Med. 2001;29(1):83–87.

49.

Shaw

Williams

Chipchase

. Do early quadriceps exercises affect the outcome of ACL reconstruction? A randomised controlled trial. Aust J Physiother. 2005;51(1):9–17.

50.

Waldén

Hägglund

Magnusson

Ekstrand

. ACL injuries in men’s professional football: a 15-year prospective study on time trends and return-to-play rates reveals only 65% of players still play at the top level 3 years after ACL rupture. Br J Sports Med. 2016;50(12):744–750.

51.

Welling

Benjaminse

Lemmink

Dingenen

Gokeler

. Progressive strength training restores quadriceps and hamstring muscle strength within 7 months after ACL reconstruction in amateur male soccer players. Phys Ther Sport. 2019;40:10–18.

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