The design and development of novel hydrogel membranes prepared by crosslinking polyvinyl alcohol with heat-treated cornstarch (CS) and CS suspensions was attempted. Degradation studies of the hydrogel membranes were conducted using α-amylase. The mechanical property of the hydrogel membranes was characterized by tensile tests. The swelling behavior of the membranes was also evaluated. Methyl tetrazolium assay of the membranes was performed using mice splenocytes and the L929 cell line to establish cytocompatibility. The membranes had sufficient strength and water holding capacity. The membrane was found to be biocompatible with L929 fibroblast cells and mice splenocytes.
GuoJ.H., CooklockK.M.Bioadhesive polymer buccal patches for buprenorphine controlled delivery. Drug Del Ind Pharm1995; 21: 2013–9.
2.
PeppasN.A.Hydrogels and drug delivery. Curr Opin Coll Interfac Sci1997; 2: 531–7.
3.
PeppasN.A., KhareA.R.Preparation, structure and diffusional behavior of hydrogels in controlled release. Adv Drug Deliv Rev1993; 11: 1–35.
4.
ColomboP., CatellaniP.L., PeppasN.A., MaggiL., ConteU.Swelling characteristics of hydrophilic matrices for controlled release: new dimensionless number to describe the swelling and release behavior. Intern J Pharm1992; 88: 99–109.
5.
KikuchiA., OkanoT.Pulsatile drug release control using hydrogels. Adv Drug Deliv Rev2002; 54: 53–77.
6.
LaPorteR.J.In Hydrophilic polymer coating for medical devices.Lancaster, USA: Technomic Publishing Co, 1997; 19–50.
7.
MackE.J., OkanoT., KimS.W. In: PeppasN.A., ed. Hydrogels in medicine and pharmacy-polymers, vol. II. Boca Raton: CRC Press, 1988; 65.
8.
KaradagE., SaraydinD., ÇentinkayaS., GuvenO.In vitro swelling studies and preliminary biocompatibility evaluation of acrylamide-base hydrogels. Biomaterials1996; 17: 67–70.
BlancoM.D., GarciaO., TrigoR.M., TeijonJ.M., KatimeI.5-Fluorouracil release from copolymer hydrogels of itaconic acid monoester. I. Acrylamide-co-monomethyl itaconate. Biomaterials1996; 17: 1061–7.
11.
HoffmanA.S.Hydrogel for biomedical applications. Adv Drug Deliv Rev2002; 54: 3–12.
12.
YoungC.D., WuJ.R., TsouT.L.Fabrication and characteristics of polyHEMA artificial skin with improved tensile properties. J Memb Sci1998; 146: 83–93.
13.
BrinkmanE., van der DoesL., BantjesA.Poly(vinyl alcohol)-heparin hydrogels as sensor catheter membranes. Biomaterials1991; 12: 63–70.
14.
TaguchiT., KishidaA., SakamotoN., AkashiM.Preparation of a novel functional hydrogel consisting on sulphated glycoside-bearing polymer: activation of basic fibroblast growth factor. J Biomed Mater Res1998; 41: 386–91.
15.
AbusafiehA., SieglerS., KalidindiS.R.Development of self-anchoring bone implants. I. Processing and material characterization. J Biomed Mater Res1997; 38: 314–27.
16.
ZhuK.J., XiangzhouL., ShilinY.Preparation, characterization, and properties of polylactide (PLA)-poly(ethylene glycol) (PEG) copolymers: a potential drug delivery carrier. J Appl Polym Sci1990; 39: 1–9.
17.
YouxinL., KisselT.Synthesis and properties of biodegradable ABA triblock copolymers consisting of poly(-lactic acid) or poly(-lactic-co-glycolic acid) A-blocks attached to central poly(oxyethylene) B-blocks. J Control Release1993; 27: 247–57.
18.
HellerJ., PangburnS.H., RoskosK.V.Development of enzymatically degradable protective coatings for use in triggered drug delivery systems: derivatized starch hydrogels. Biomaterials1990; 11: 345–50.
19.
PereiraC.S., CunhaA.M., ReisR.L., VazquezB., San RomanJ.New starch-based thermoplastic hydrogels for use as bone cements or drug delivery carriers. J Mater Sci Mater Med1998; 9: 825–33.
20.
BastioliC.In Degradable polymer principles and applications.London: Chapman and Hall, 1995; 112.
21.
VernonB., KimS.W., BaeY.H.Insulin release from islets of Langerhans entrapped in a poly(N-isopropylacrylamide-co-acrylic acid) polymer gel. J Biomater Sci Polym Edn1999; 10: 183–98.
22.
BearingerJ.P., CastnerD.G., HealyK.E.Bimolecular modification of p(AAm-co-EG/AA) IPNs support osteoblast adhesion and phenotypic expression. J Biomater Sci Polym Edn1998; 9: 629–52.
23.
DharaD., NishaC.K., ChatterjiP.R.Superabsorbent hydrogels: interpenetrating networks of poly(acrylamide-co-acrylic acid) and poly(vinyl alcohol): swelling behaviour and structural parameters. JMS Pure Appl Chem1999; A36: 197–210.
24.
AokiT., KawashimaM., KatonoH.. Temperature-responsive interpenetrating polymer networks constructed with polyacrylic acid and poly(N,N-dimethylacrylamide). Macromolecules1994; 27: 947–52.
