Abstract
The Parameter Estimation Analysis System (PEAS), designed to be used by biologists, pharmacologists, etc. in their laboratories, has been developed. It facilitates the estimation of biologically relevant parameters by analyzing data derived from screening assays. Each assay is associated with a predefined mathematical model, the parameters of which have biological meaning, and yield relevant measures of important biological activity. The system is menu-driven, with a two-tier menu structure, based upon a classification of studies within major biological categories and assays within classes. PEAS allows the user to enter, modify, and fit his/her data in a user-friendly manner. They will then generate accurate parameter estimates for the user-specified model and generate any secondary parameters or statistics based upon the model. The system displays graphical data interactively on the screen for review, and generates customized hardcopy reports. The design of PEAS and its implementation are discussed. Additionally, the role of PEAS in a company-wide database management system is also described.
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