Role of Triarchic Traits in Relations of Early Resting Heart Rate With Antisocial Behavior and Broad Psychopathology Dimensions in Later Life

Abstract

Low resting heart rate (HR) is a known risk indicator for the development of antisocial behavior (ASB) and other clinical problems. Stimulation seeking and fearlessness have been explored as factors underlying the HR/ASB relationship, but these have often been conflated, which has complicated interpretation. We examined HR’s associations with ASB and other outcomes in terms of biobehavioral traits described by the triarchic model of psychopathy using data (N = 710) from a longitudinal study of ASB risk. Low resting HR in childhood was related to adult ASB, and covariance between ASB and traits of disinhibition and boldness largely accounted for this association. In addition, low childhood HR was related to greater externalizing problems and fewer internalizing problems in adulthood; disinhibition accounted for the former association, and boldness accounted for the latter. Findings indicate a role for both disinhibition and boldness in associations between early HR and later clinical outcomes and have implications for theory and practice.

Keywords

heart rate antisocial behavior externalizing internalizing triarchic model

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References

Achenbach

T. M.

Rescorla

L. A.

(2003). Manual for the ASEBA Adult Forms & Profiles. University of Vermont Research Center for Children, Youth, & Families.

American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). https://doi.org/10.1176/appi.books.9780890425596

Baker

L. A.

Barton

Lozano

D. I.

Raine

Fowler

J. H.

(2006). The Southern California Twin Register at the University of Southern California: II. Twin Research and Human Genetics, 9(6), 933–940.

Baker

L. A.

Barton

Raine

(2002). The Southern California Twin Register at the University of Southern California. Twin Research, 5, 456–459.

Baker

L. A.

Tuvblad

Wang

Gomez

Bezdjian

Niv

Raine

(2013). The Southern California Twin Register at the University of Southern California: III. Twin Research and Human Genetics, 16(1), 336–343.

Baroncelli

Perkins

E. R.

Ciucci

Frick

P. J.

Patrick

C. J.

Sica

(2020). Triarchic model traits as predictors of bullying and cyberbullying in adolescence. Journal of Interpersonal Violence, 37(5-6), NP3242–NP3268. https://doi.org/10.1177/0886260520934448

Benning

S. D.

Patrick

C. J.

Blonigen

D. M.

Hicks

B. M.

Iacono

W. G.

(2005). Estimating facets of psychopathy from normal personality traits: A step toward community epidemiological investigations. Assessment, 12(1), 3–18.

Benning

S. D.

Patrick

C. J.

Iacono

W. G.

(2005). Psychopathy, startle blink modulation, and electrodermal reactivity in twin men. Psychophysiology, 42, 753–762.

Blair

R. J. R.

(2005). Responding to the emotions of others: Dissociating forms of empathy through the study of typical and psychiatric populations. Consciousness and Cognition, 14, 698–718.

10.

Blonigen

Hicks

B. M.

Krueger

R. F.

Patrick

C. J.

Iacono

W. G.

(2005). Psychopathic personality traits: Heritability and genetic overlap with internalizing and externalizing psychopathology. Psychological Medicine, 35, 637–648.

11.

Brislin

S. J.

Drislane

L. E.

Smith

S. T.

Edens

J. F.

Patrick

C. J.

(2015). Development and validation of triarchic psychopathy scales from the Multidimensional Personality Questionnaire. Psychological Assessment, 27(3), 838–851.

12.

Brislin

S. J.

Patrick

C. J.

(2019). Callousness and affective face processing: Clarifying the neural basis of behavioral-recognition deficits through the use of brain event-related potentials. Clinical Psychological Science, 7(6), 1389–1402.

13.

Brislin

S. J.

Patrick

C. J.

Flor

Nees

Heinrich

Drislane

L. E.

Büchel

(2019). Extending the construct network of trait disinhibition to the neuroimaging domain: Validation of a bridging scale for use in the European IMAGEN project. Assessment, 26(4), 567–581.

14.

Brislin

S. J.

Venables

N. C.

Drislane

L. E.

Blonigen

D. M.

Iacono

W. G.

Tellegen

Edens

J. F.

Patrick

C. J.

(2017). Further validation of triarchic psychopathy scales from the Multidimensional Personality Questionnaire: Setting the stage for large-sample etiological studies. Assessment, 24(5), 575–590. https://doi.org/10.1177/1073191115621790

15.

Davidson

R. J.

Putnam

K. M.

Larson

C. L.

(2000). Dysfunction in the neural circuit of emotion regulation—A possible prelude to violence. Science, 289(5479), 591–594.

16.

Davies

J. G. V.

Maliphant

(1971). Autonomic responses of male adolescents exhibiting refractory behaviour in school. Journal of Child Psychology and Psychiatry, 12(2), 115–127.

17.

Decety

Skelly

L. R.

Kiehl

K. A.

(2013). Brain response to empathy-eliciting scenarios involving pain in incarcerated individuals with psychopathy. JAMA Psychiatry, 70(6), 638–645. https://doi.org/10.1001/jamapsychiatry.2013.27

18.

De Vries-Bouw

Popma

Vermeiren

Doreleijers

T. A. H.

Van de Ven

P. M.

Jansen

L. M. C.

(2011). The predictive value of low heart rate and heart rate variability during stress for reoffending in delinquent male adolescents. Psychophysiology, 48, 1596–1603.

19.

Dindo

Fowles

(2011). Dual temperamental risk factors for psychopathic personality: Evidence from self-report and skin conductance. Journal of Personality & Social Psychology, 100(3), 557–566.

20.

Donnellan

M. B.

Burt

(2016). A further evaluation of the triarchic conceptualization of psychopathy in college students. Journal of Psychopathology and Behavioral Assessment, 38, 172–182.

21.

Drislane

L. E.

Brislin

S. J.

Jones

Patrick

C. J.

(2018). Interfacing five-factor model and triarchic conceptualizations of psychopathy. Psychological Assessment, 30(6), 834–840.

22.

Drislane

L. E.

Patrick

C. J.

(2017). Integrating alternative conceptions of psychopathic personality: A latent variable model of triarchic psychopathy constructs. Journal of Personality Disorders, 31(1), 1–23.

23.

Drislane

L. E.

Patrick

C. J.

Arsal

(2014). Clarifying the content coverage of differing psychopathy inventories through reference to the Triarchic Psychopathy Measure. Psychological Assessment, 26(2), 350–362.

24.

Dvorak-Bertsch

J. D.

Curtin

J. J.

Rubinstein

T. J.

Newman

J. P.

(2009). Psychopathic traits moderate the interaction between cognitive and affective processing. Psychophysiology, 46(5), 913–921.

25.

Esteller

Poy

Moltó

(2016). Deficient aversive-potentiated startle and the triarchic model of psychopathy: The role of boldness. Biological Psychology, 117, 131–140.

26.

Eysenck

H. J.

(1997). Personality and the biosocial model of antisocial and criminal behavior. In Raine

Brennan

Farrington

Mednick

S. A.

(Eds.), Biosocial bases of violence (pp. 21–38). Springer.

27.

Farrington

D. P.

(1997). The relationship between low resting heart rate and violence. In Raine

Brennan

Farrington

Mednick

S. A.

(Eds.), Biosocial bases of violence (pp. 89–105). Springer.

28.

Farrington

D. P.

(2020). Interactions between resting heart rate and childhood risk factors in predicting criminal convictions and antisocial personality scores. Crime & Delinquency, 66(10), 1369–1391.

29.

Foell

Brislin

S. J.

Strickland

C. J.

Seo

Sabatinelli

Patrick

C. J.

(2016). Externalizing proneness and brain response during pre-cueing and viewing of emotional pictures. Social Cognitive and Affective Neuroscience, 11(7), 1102–1110.

30.

Frick

P. J.

Morris

A. S.

(2004). Temperament and developmental pathways to conduct problems. Journal of Clinical Child and Adolescent Psychology, 33(1), 54–68.

31.

Frick

P. J.

Ray

J. V.

Thornton

L. C.

Kahn

R. E.

(2014). Can callous-unemotional traits enhance the understanding, diagnosis, and treatment of serious conduct problems in children and adolescents? A comprehensive review. Psychological Bulletin, 140, 1–57.

32.

Gray

N. S.

Blumenthal

Shuker

Wood

Fonagy

Snowden

R. J.

(2021). The triarchic model of psychopathy and antisocial behavior: Results from an offender population with personality disorder. Journal of Interpersonal Violence, 36(17–18), NP9130–NP9152. https://doi.org/10.1177/0886260519853404

33.

Hammerton

Heron

Mahedy

Maughan

Hickman

Murray

(2017). Low resting heart rate, sensation seeking and the course of antisocial behavior across adolescence and young adulthood. Psychological Medicine, 48(13), 2194–2201.

34.

Hare

R. D.

(1965a). Acquisition and generalization of a conditioned fear response in psychopathic and nonpsychopathic criminals. The Journal of Psychology: Interdisciplinary and Applied, 59(2), 367–370.

35.

Hare

R. D.

(1965b). Temporal gradient of fear arousal in psychopaths. Journal of Abnormal Psychology, 70(6), 442–445.

36.

Hare

R. D.

Quinn

M. J.

(1971). Psychopathy and autonomic conditioning. Journal of Abnormal Psychology, 77(3), 223–235.

37.

Hollingshead

A. G.

(2011). Four-factor index of social status. Yale Journal of Sociology, 8, 21–52. https://sociology.yale.edu/sites/default/files/files/yjs_fall_2011.pdf

38.

Jennings

W. G.

Piquero

A. R.

Farrington

D. P.

(2013). Does resting heart rate at age 18 distinguish general and violent offending up to age 50? Findings from the Cambridge Study in Delinquent Development. Journal of Criminal Justice, 41(4), 213–219.

39.

Kendler

K. S.

Lönn

S. L.

Sundquist

(2020). The causal nature of the association between resting pulse in late adolescence and risk for internalizing and externalizing disorders: A co-relative analysis in a national male Swedish sample. Psychological Medicine, 24, 1–7.

40.

Koegl

C. J.

Farrington

D. P.

Raine

(2018). The relationship between low resting heart rate, systolic blood pressure and antisocial behavior in incarcerated males. Journal of Criminal Justice, 55, 88–95.

41.

Kramer

M. D.

Patrick

C. J.

Krueger

R. F.

Gasperi

(2012). Delineating physiologic defensive reactivity in the domain of self-report: Phenotypic and etiologic structure of dispositional fear. Psychological Medicine, 42, 1305–1320.

42.

Krueger

R. F.

(1999). The structure of common mental disorders. Archives of General Psychiatry, 56, 921–926.

43.

Krueger

R. F.

Hicks

Patrick

C. J.

Carlson

Iacono

W. G.

McGue

(2002). Etiologic connections among substance dependence, antisocial behavior, and personality: Modeling the externalizing spectrum. Journal of Abnormal Psychology, 111, 411–424.

44.

Krueger

R. F.

Markon

K. E.

Patrick

C. J.

Benning

S. D.

Kramer

M. D.

(2007). Linking antisocial behavior, substance use, and personality: An integrative quantitative model of the adult externalizing spectrum. Journal of Abnormal Psychology, 116(4), 645–666.

45.

Kyranides

M. N.

Fanti

K. A.

Sikki

Patrick

C. J.

(2017). Triarchic dimensions of psychopathy in young adulthood: Associations with clinical and physiological measures after accounting for adolescent psychopathic traits. Personality Disorders: Theory, Research, and Treatment, 8(2), 140–149.

46.

Latvala

Kuja-Halkola

Almqvist

Larsson

Lichtenstein

(2015). A longitudinal study of resting heart rate and violent criminality in more than 700,000 men. JAMA Psychiatry, 72(10), 971–978.

47.

Latvala

Kuja-Halkola

Rück

D’Onofrio

B. M.

Jernberg

Almqvist

Mataix-Cols

Larsson

Lichtenstein

(2016). Association of resting heart rate and blood pressure in late adolescence with subsequent mental disorders: A longitudinal population study of more than 1 million men in Sweden. JAMA Psychiatry, 73(12), 1268–1275.

48.

Latzman

R. D.

Palumbo

I. M.

Krueger

R. F.

Drislane

L. E.

Patrick

C. J.

(2020). Modeling relations between triarchic biobehavioral traits and DSM internalizing disorder dimensions. Assessment, 27(6), 1100–1115.

49.

Latzman

R. D.

Palumbo

I. M.

Sauvigné

K. C.

Hecht

L. K.

Lilienfeld

S. O.

Patrick

C. J.

(2019). Psychopathy and internalizing psychopathology: A triarchic model perspective. Journal of Personality Disorders, 33(2), 262–287.

50.

Lykken

D. T.

(1995). The antisocial personalities. Erlbaum.

51.

Lynam

D. R.

(1996). Early identification of chronic offenders: Who is the fledgling psychopath? Psychological Bulletin, 120(2), 209–234.

52.

Marsh

A. A.

Blair

R. J. R.

(2008). Deficits in facial affect recognition among antisocial populations: A meta-analysis. Neuroscience & Biobehavioral Reviews, 32, 454–465.

53.

Marsh

A. A.

Finger

E. C.

Mitchell

G. V.

Reid

M. E.

Sims

Kosson

D. S.

Towbin

K. E.

Leibenluft

Pine

D. S.

Blair

R. J.

(2008). Reduced amygdala response to fearful expressions in children and adolescents with callous–unemotional traits and disruptive behavior disorders. American Journal of Psychiatry, 165(6), 712–720. https://doi.org/10.1176/appi.ajp.2007.07071145

54.

Miller

G. A.

Lynam

D. R.

(2012). An examination of the Psychopathic Personality Inventory’s nomological network. A meta-analytic review. Personality Disorders: Theory, Research, and Treatment, 3(3), 305–326.

55.

Moffitt

T. E.

Caspi

(2001). Childhood predictors differentiate life-course persistent and adolescent limited pathways among males and females. Development and Psychopathology, 13(2), 355–375.

56.

Murray

Hallal

P. C.

Mielke

G. I.

Raine

Wehrmeister

F. C.

Anselmi

Barros

F. C.

(2016). Low resting heart rate is associated with violence in late adolescence: A prospective birth cohort study in Brazil. International Journal of Epidemiology, 45(2), 491–500.

57.

Muthén

L. K.

Muthén

B. O.

(2017). Mplus user’s guide (8th ed.).

58.

Paiva

T. O.

Pasion

Patrick

C. J.

Moreira

Almeida

P. R.

Barbosa

(2020). Further evaluation of the Triarchic Psychopathy Measure: Evidence from community adult and prisoner samples from Portugal. Psychological Assessment, 32(3), e1–e14. https://doi.org/10.1037/pas0000797

59.

Palumbo

I. M.

Perkins

E. R.

Yancey

J. R.

Brislin

S. J.

Patrick

C. J.

Latzman

R. D.

(2020). Toward a multimodal measurement model for the neurobehavioral trait of affiliative capacity. Personality Neuroscience, 3, Article e11. https://doi.org/10.1017/pen.2020.9

60.

Patrick

C. J.

(1994). Emotion and psychopathy: Startling new insights. Psychophysiology, 31(4), 319–330.

61.

Patrick

C. J.

(2010). Operationalizing the triarchic conceptualization of psychopathy: Preliminary description of brief scales for assessment of boldness, meanness, and disinhibition. https://www.phenxtoolkit.org/protocols/view/121601

62.

Patrick

C. J.

(2018). Cognitive and emotional processing in psychopathy. In Patrick

C. J.

(Ed.), Handbook of psychopathy (2nd ed.; pp. 422–455). The Guilford Press.

63.

Patrick

C. J.

(2022). Psychopathy: Current knowledge and future directions. Annual Review of Clinical Psychology, 18, 388–415. https://doi.org/10.1146/annurev-clinpsy-072720-012851

64.

Patrick

C. J.

Drislane

L. E.

(2015). Triarchic model of psychopathy: Origins, operationalizations, and observed linkages with personality and general psychopathology. Journal of Personality, 83(6), 627–643.

65.

Patrick

C. J.

Durbin

C. E.

Moser

J. S.

(2012). Reconceptualizing antisocial deviance in neurobehavioral terms. Development and Psychopathology, 24(3), 1047–1071.

66.

Patrick

C. J.

Fowles

D. C.

Krueger

R. F.

(2009). Triarchic conceptualization of psychopathy: Developmental origins of disinhibition, boldness, and meanness. Development and Psychopathology, 21(3), 913–938.

67.

Patrick

C. J.

Iacono

W. G.

Venables

N. C.

(2019). Incorporating neurophysiological measures into clinical assessments: Fundamental challenges and a strategy for addressing them. Psychological Assessment, 31(12), 1512–1529.

68.

Patrick

C. J.

Joyner

K. J.

Watts

A. L.

Lilienfeld

S. O.

Somma

Fossati

Donnellan

M. B.

Hopwood

C. J.

Sellbom

Drislane

L. E.

Edens

J. F.

Verona

Latzman

R. D.

Sica

Benning

S. D.

Morey

L. C.

Hicks

B. M.

Fanti

K. A.

Blonigen

D. M.

. . . Krueger

R. F.

(2021). Latent variable modeling of item-based factor scales: Comment on Triarchic or septarchic?—Uncovering the Triarchic Psychopathy Measure’s (TriPM) Structure, by Roy et al. Personality Disorders: Theory, Treatment, and Research, 12(1), 16–23. https://doi.org/10.1037/per0000424

69.

Patrick

C. J.

Kramer

Krueger

R. F.

Markon

K. E.

(2013). Optimizing efficiency of psychopathology assessment through quantitative modeling: Development of a brief form of the Externalizing Spectrum Inventory. Psychological Assessment, 25(4), 1332–1348.

70.

Patrick

C. J.

Kramer

M. D.

Vaidyanathan

Benning

S. D.

Hicks

B. M.

Lilienfeld

S. O.

(2019). Formulation of a measurement model for the boldness construct of psychopathy. Psychological Assessment, 31, 643–659.

71.

Patterson

C. M.

Newman

J. P.

(1993). Reflectivity and learning from aversive events: Toward a psychological mechanism for the syndromes of disinhibition. Psychological Review, 100(4), 716–736.

72.

Perkins

E. R.

Joyner

K. J.

Foell

Drislane

L. E.

Brislin

S. J.

Yancey

J. R.

Soto

E. F.

Ganley

C. M.

Keel

P. K.

Sica

Flor

Nees

Banaschewski

Bokde

A. L. W.

Quinlan

E. B.

Desrivières

Grigis

Garavan

Gowland

, . . . The IMAGEN Consortium. (in press). Assessing general versus specific liability for externalizing problems in adolescence: Concurrent and prospective prediction of conduct disorder, ADHD, and substance use. Journal of Psychopathology and Clinical Science.

73.

Portnoy

Raine

Chen

F. R.

Pardini

D. A.

Loeber

Jennings

J. R.

(2014). Heart rate and antisocial behavior: The mediating role of impulsive sensation seeking. Criminology, 52(2), 292–311.

74.

Poy

Segarra

Esteller

À.

López

Moltó

(2014). FFM description of the triarchic conceptualization of psychopathy in men and women. Psychological Assessment, 26(1), 69–76.

75.

Quay

H. C.

(1965). Psychopathic personality as pathological stimulation-seeking. American Journal of Psychiatry, 122, 180–183.

76.

Raine

(1993). The psychopathology of crime: Criminal behavior as a clinical disorder. Academic Press.

77.

Raine

(2002). Annotation: The role of prefrontal deficits, low autonomic arousal, and early health factors in the development of antisocial and aggressive behavior in children. Journal of Child Psychology and Psychiatry, 43(4), 417–434.

78.

Raine

Fung

A. L. C.

Portnoy

Choy

Spring

V. L.

(2014). Low heart rate as a risk factor for child and adolescent proactive aggressive and impulsive psychopathic behavior. Aggressive Behavior, 40, 290–299.

79.

Raine

Reynolds

Venables

P. H.

Mednick

S. A.

Farrington

D. P.

(1998). Fearlessness, stimulation-seeking, and large body size at age 3 years as early predispositions to childhood aggression at age 11 years. Archives of General Psychiatry, 55(8), 745–751.

80.

Ribes-Guardiola

Poy

Patrick

C. J.

Moltó

(2020). Electrocortical measures of performance monitoring from go/no-go and flanker tasks: Differential relations with trait dimensions of the triarchic model of psychopathy. Psychophysiology, 57, 1–22.

81.

Scerbo

Raine

Venables

P. H.

Mednick

S. A.

(1993). Relationships between autonomic arousal at age 3 and temperament at ages 8 to 11 years. Journal of Abnormal Psychology, 18, 451–463.

82.

Sellbom

(2018). The triarchic psychopathy model: Theory and measurement. In DeLisi

(Ed.), Routledge international handbook of psychopathy and crime (pp. 241–264). Routledge.

83.

Sellbom

Phillips

T. R.

(2013). An examination of the triarchic conceptualization of psychopathy in incarcerated and nonincarcerated samples. Journal of Abnormal Psychology, 122(1), 208–214.

84.

Sijtsema

J. J.

Veenstra

Lindenberg

van Roon

A. M.

Verhulst

F. C.

Ormel

F. C.

Riese

(2010). Mediation of sensation seeking and behavioral inhibition on the relationship between heart rate and antisocial behavior: The TRAILS study. Journal of the American Academy of Child and Adolescent Psychiatry, 49(5), 493–502.

85.

Snyder

H. R.

Miyake

Hankin

B. L.

(2015). Advancing understanding of executive function impairments and psychopathology: Bridging the gap between clinical and cognitive approaches. Frontiers in Psychology, 6, Article 328. https://doi.org/10.3389/fpsyg.2015.00328

86.

Somma

Borroni

Drislane

L. E.

Patrick

C. J.

Fossati

(2019). Modeling the structure of the Triarchic Psychopathy Measure: Conceptual, empirical, and analytic considerations. Journal of Personality Disorders, 33(4), 470–496.

87.

Spaeth

Weichold

Silbereison

R. K.

(2015). The development of leisure boredom in early adolescence: Predictors and longitudinal associations with delinquency and depression. Developmental Psychology, 51(10), 1380–1394.

88.

Stanley

J. H.

Wygant

D. B.

Sellbom

(2013). Elaborating of the construct validity of the triarchic psychopathy measure in a criminal offender sample. Journal of Personality Assessment, 95, 343–350.

89.

Venables

N. C.

Foell

Yancey

J. R.

Kane

M. J.

Engle

R. W.

Patrick

C. J.

(2018). Quantifying inhibitory control as externalizing proneness: A cross-domain model. Clinical Psychological Science, 6(4), 561–580.

90.

Venables

N. C.

Patrick

C. J.

(2012). Validity of the Externalizing Spectrum Inventory in a criminal offender sample: Relations with disinhibitory psychopathology personality and psychopathology, personality, and psychopathic features. Psychological Assessment, 24(1), 88–100.

91.

Viding

McCrory

(2019). Towards understanding atypical social affiliation in psychopathy. The Lancet Psychiatry, 6(5), 437–444.

92.

Wang

Niv

Tuvblad

Raine

Baker

L. A.

(2013). The genetic and environmental overlap between aggressive and non-aggressive antisocial behavior in children and adolescents using the self-report delinquency interview (SR-DI). Journal of Criminal Justice, 41(5), 277–284.

93.

Yancey

J. R.

Bowyer

C. B.

Foell

Boot

W. R.

Patrick

C. J.

(2019). Boldness moderates the effects of external threat on performance within a task-switching paradigm. Journal of Experimental Psychology: Human Perception and Performance, 45(6), 758–770.

94.

Yancey

J. R.

Venables

N. C.

Hicks

B. M.

Patrick

C. J.

(2013). Evidence for a heritable brain basis to deviance-promoting deficits in self-control. Journal of Criminal Justice, 41(5), 309–317.

95.

Yancey

J. R.

Venables

N. C.

Patrick

C. J.

(2016). Psychoneurometric operationalization of threat sensitivity: Relations with clinical symptom and physiological response criteria. Psychophysiology, 53(3), 393–405.

96.

Young

S. E.

Friedman

N. P.

Miyake

Willcutt

E. G.

Corley

R. P.

Haberstick

B. C.

Hewitt

J. K.

(2009). Behavioral disinhibition: Liability for externalizing spectrum disorders and its genetic and environmental relation to response inhibition across adolescence. Journal of Abnormal Psychology, 118(1), 117–130.

97.

Young

S. E.

Stallings

M. C.

Corley

R. P.

Krauter

K. S.

Hewitt

J. K.

(2000). Genetic and environmental influence on behavioral disinhibition. American Journal of Medical Genetics (Neuropsychiatric Genetics), 96(5), 684–695.

98.

Zuckerman

M. D.

Neeb

(1979). Sensation seeking and psychopathology. Psychiatry Research, 1(3), 255–264.

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