Abstract
Background
Low back pain (LBP) is a prevalent condition in working populations, imposing significant individual, organisational, and societal burdens, including reduced quality of life, impaired work performance, and high healthcare costs. Digital health interventions (DHIs) offer scalable solutions for self-managing LBP in workplace settings, yet their tailoring, integration, and effectiveness remain unclear.
Objective
This systematic review evaluates the effectiveness of DHIs in supporting LBP self-management in workplace environments. It examines intervention components, tailoring methods, integration with occupational health (OH) pathways, and their impact on clinical and work-related outcomes.
Methods
A systematic search was conducted across PubMed, MEDLINE, EMBASE, CINAHL, the Cochrane Library, and Web of Science, following PRISMA guidelines. Randomised controlled trials evaluating DHIs for workplace LBP were included. Data extraction focused on intervention characteristics, tailoring approaches, and primary outcomes, including pain intensity, disability, and physical performance. The quality of evidence was assessed using the Cochrane risk-of-bias and GRADE frameworks.
Results
Five studies were included, featuring DHIs delivered via web-based platforms or mobile applications. Interventions incorporated exercise, ergonomics education, and work activity modification. Only one study used a tailored approach based on theoretical frameworks and individualised work classifications. Moderate-quality evidence supported improvements in pain, disability, and physical performance, but effects on quality of life, psychosocial factors, and work outcomes were inconsistent. Integration with occupational health pathways was absent in all studies.
Conclusions
The lack of tailoring and integration within occupational health systems limits the scalability and impact of DHIs for workplace LBP. Future research should focus on personalised, theory-driven interventions and systemic alignment with occupational health policies to enhance their feasibility, implementation, and long-term outcomes.
Introduction
Low back pain (LBP), defined as pain occurring between the lower rib margin and the buttock creases with or without neurological symptoms in the lower limbs, 1 is a prevalent public health issue and the leading global cause of disability. 2 The majority of LBP is termed non-specific LBP, characterised by pain that is not attributed to any specific, identifiable pathological cause. 3 While acute pain symptoms may resolve within 4–6 weeks, one in three individuals continue to report persistent pain 1 year after onset. 4 LBP prevalence peaks at 42% among working-age individuals between 40 and 69 years. 5 As the second most common cause of absenteeism, LBP leads to significant direct and indirect costs, 6 imposing substantial burdens on individuals, organisations, and governments. 7 In the UK, 7.8 million workdays were lost due to musculoskeletal disorders between 2023 and 2024, with LBP most prevalent. 8 An enormous financial burden stemming from LBP has also been reported, with an estimated £3.5 billion in direct healthcare costs related to consultations and prescriptions. 9 Within the workplace, the burden of LBP is further exacerbated, leading to presenteeism (working whilst ill), productivity losses, and reduced job satisfaction, which in turn impact staff retention and increase litigation risks.10,11
Workplace interventions for LBP include ergonomic adjustments, exercise programmes, 12 and worksite training 13 but these often target single factors and lack flexibility for diverse occupational settings limiting their effectiveness. 14 To address these limitations, multifaceted interventions integrating ergonomic, psychological, educational, and exercise components have been developed and shown effectiveness.15,16 More recently, self-management interventions have gained prominence as the first line of treatment, empowering individuals to develop self-management skills and confidence in managing their condition.17,18 Growing research on workplace self-management, supported by several systematic reviews (SRs), highlights the potential of person-centred self-management interventions, such as participatory ergonomics 19 and tailored exercise programmes, 20 to improve clinical and work-related outcomes while emphasising the critical influence of the intervention tailoring to individual's and job demands, and organisational support.12,16,19,21–26
Digital health technologies offer an accessible and scalable approach to self-management, supporting its delivery through information technology such as computers, mobile phones, and handheld devices to deliver evidence-based support. 27 Evidence suggests that digital health interventions (DHIs) designed to support self-management aligned with workplace representatives’ needs could bring improvements in pain and function for chronic conditions including LBP, but the included studies were not limited to workplace settings. 28 Most research has been conducted in clinical settings, with limited evaluation taking place in workplace environments.29,30 In addition, the challenges remain regarding tailoring interventions to individual and workplace-specific needs, as well as their integration into existing occupational health frameworks, both of which are crucial for successful implementation and sustained impact. 31
Therefore, this SR aims to evaluate the effectiveness of workplace-based DHIs that support self-management of LBP on health and work outcomes, examine how these interventions are tailored to individual and occupational needs, and assess their integration into workplace health pathways. Findings will provide insights to enhance the design and implementation of DHIs for workplace LBP management.
Materials and methods
This SR was designed and reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines 32 [Supplemental Appendix 1]. The protocol was pre-registered in PROSPERO (ID: CRD42023435184).
Inclusion criteria
The eligibility criteria for this review were defined using the PICO framework. 33
Studies included working populations with LBP, defined as pain between the lower rib margin and buttock creases, 1 lasting over 4 weeks (subacute and chronic). 34 Participants presenting red flags for serious pathology or systemic illness were excluded. The working population included individuals in full-time, part-time, or self-employed roles with no restriction on occupation type. 35 Eligible interventions were DHIs that delivered self-management information via computers, mobile phones, or handheld devices without requiring direct feedback from healthcare professionals. 27 Studies involving DHIs integrated into medical treatments or without pre-designed intervention content were excluded. Control groups in eligible studies could include usual care, non-digital self-management interventions, or non-tailored DHIs to support self-management. The review considered primary outcomes such as pain intensity and disability levels measured by validated scales.30,36 Secondary outcomes included work-related measures like absenteeism and productivity, as well as quality of life, physical performance, and psychosocial factors such as stress, anxiety, and depression. Only randomised controlled trials (RCTs) published in English were included.
Search methods
A three-step search strategy was used to identify studies published in six databases from inception up to February 2023, with the final search conducted in March 2024. An initial pilot search of MEDLINE was conducted to refine search terms. Subsequently, a comprehensive search was carried out in PubMed, MEDLINE, EMBASE, CINAHL, the Cochrane Library, and Web of Science. The search terms were grouped into three concepts: (1) LBP, (2) DHIs, and (3) workplace [Supplemental Appendix 2]. Additional searches included reference lists from relevant reviews, unpublished theses, conference papers, and trial registrations to ensure comprehensive coverage.
Data collection, analysis, and outcomes
All identified studies were uploaded to Rayyan for screening and analysis. 37 Titles and abstracts were screened independently by two reviewers (MC and LS), with discrepancies resolved through consultation with a third reviewer (VS). Data from included studies were extracted into an Excel spreadsheet, covering study characteristics (e.g. publication date, population demographics, and intervention details) and outcomes (e.g. pain, disability, and work-related measures). Due to heterogeneity in intervention content, control settings, and outcome measures, a meta-analysis was deemed inappropriate. Instead, a narrative synthesis was used to describe the study findings. 38 Given the moderate to high risk of bias and substantial heterogeneity across studies,39,40 statistical pooling through meta-analysis was not conducted. Descriptive tables summarised study characteristics, and narrative synthesis provided insights into intervention effects on primary and secondary outcomes.
Risk of bias assessment
The risk of bias in included studies was assessed using the Cochrane Risk of Bias Tool, 41 evaluating factors such as sequence generation, allocation concealment, blinding, incomplete data management, selective reporting, and other potential biases. Two reviewers (MC and LS) independently assessed the studies, with disagreements resolved by a third reviewer (VS).
Quality assessment
To assess the quality and strength of the evidence, the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) framework was applied. This involved evaluating five factors – risk of bias, inconsistency, indirectness, imprecision, and publication bias – for each outcome, categorising them as not serious, serious, or very serious. Outcomes from RCTs were initially rated as high-quality evidence but could be downgraded to moderate, low, or very low quality based on these criteria. This comprehensive approach ensured a nuanced interpretation of the findings within the context of the evidence's strengths and limitations. Two reviewers carried out the quality assessment independently, with any disagreements resolved through discussion or consultation with a third reviewer.
Results
Results of the search
An initial search of six major databases yielded 5457 articles, with an additional nine studies identified from other sources. After removing duplicates, 4103 records were screened in Rayyan, with 10% reviewed by two independent reviewers, achieving moderate inter-reviewer agreement (kappa = 0.44).
42
Discrepancies were resolved through discussion with a second reviewer (LS). During title screening, 1517 irrelevant articles were excluded, and abstract screening eliminated 2133 additional records, leaving 453 for full-text review. Ultimately, five articles met the eligibility criteria and were included in this review [Table 1]. To ensure a comprehensive search, reference lists of included studies were reviewed, but no additional articles were identified. One study included university students and retired employees in the sample; however, it was retained due to the small size of the non-working group (

Flow diagram of the search strategy and selection process using preferred reporting items for systematic reviews (PRISMA).
Study and participant demographic characteristics.
N/R: not reported; IG: intervention group; CG: control group; Sickness absence: sick leave days due to low back pain from last year.
Quality appraisal
The quality of the five included trials was assessed using the Cochrane Collaboration's Risk of Bias tool. 41 Overall, the studies demonstrated low to moderate quality, with notable variability in reporting practices [Figure 2].

Risk assessment of bias in the included studies.
Four trials used computer-generated random sequences for allocation,43–46 while one did not specify the method used. 47 Allocation concealment was adequate in four trials but was not reported in one. 47 Blinding practices varied. Two trials employed double-blind designs,44,46 one used single blinding, 45 and two either lacked blinding or provided insufficient details.45,47 High attrition rates (55%) were observed in one trial, 46 while another reported fraudulent recruitment practices and incomplete data reporting. 47 Reporting bias was evident in one trial that inconsistently presented baseline and follow-up results. 43 Four trials were funded by independent research grants, indicating a low risk of funding bias.43–46 One trial was funded by a healthcare technology company that developed the DHI under investigation, raising potential concerns about conflicts of interest. 47 Additional risks included incomplete reporting of data security measures and unclear intervention details in some studies. Using the GRADE framework, primary outcomes such as pain intensity and disability were rated as moderate quality due to methodological limitations. Secondary outcomes, including psychosocial and work-related measures, were rated as low to very low quality because of variability in reporting. These findings underscore the need for more robust trials to evaluate DHIs for LBP management in workplace settings.
Demographic data
The five RCTs included in this review were published between 2015 and 2021. Two were conducted in Spain,43,46 one in the USA, 47 one in Japan, 45 and one in Jordan. 44 The trials lasted between 6 weeks and 6 months. A total of 840 participants were enrolled, with 322 allocated to intervention groups and 518 to control groups. Sample sizes ranged from 18 to 398 participants. Slightly more than half of the participants were female (56.3%), with individual studies reporting proportions ranging from 18.7% to 88.6%. Only one study 47 reported demographic data on ethnicity, education, and income. Mean participant ages ranged from 40.48 to 46.83 years,43–46 except for one study that did not report age. 47 All participants were employed, with employment rates ranging from 95.5% to 100%. Three trials took place in office settings,43,44,47 while two were conducted in manufacturing settings.45,46 Reported annual workdays lost to LBP ranged from 3.10 to 12.12 days in three studies.44,46,47
No studies reported the use of diagnostic imaging. One study included participants diagnosed with LBP by a physician within the past 3 months as an inclusion criterion. 46 The remaining four studies included individuals with self-reported non-specific LBP, excluding those with a documented diagnosis of a specific pathology excluded.43–45,47 Eligibility criteria for LBP duration varied, with studies including participants with subacute LBP (4–12 weeks), 43 chronic LBP (over 3 months), 44 and those who had non-specific LBP within the past 3 months.45–47 Baseline levels of pain intensity, disability, quality of life, physical performance, and psychosocial outcomes across the five studies are presented in Table 2.
Baseline pain-related participant characteristics.
N/R: not reported; IG: intervention group; CG: control group; SD: standard deviation.
Intervention characteristics
The five included trials utilised diverse DHIs delivered via mobile applications (
Description of characteristics of digital health intervention in selected trials.
N/R: not reported; AI: artificial intelligence.
Exercise
All five trials included exercise as a key intervention component, though the presentation and specificity varied. Two studies delivered exercises via pre-recorded videos,43,47 and two used text and images.44,45 One study did not specify the method used to demonstrate exercises. 46 Three studies incorporated exercise management with intervention durations ranging from 6 weeks to 9 months.43–45 Three DHIs included exercises targeting key muscle groups, such as the abdominal, lumbar, hip, and thigh muscles43,44 as well as the lumbar spine 46 utilising both flexion and extension movements. The remaining two studies referenced evidence-based exercise guidelines, including recommendations from the American College of Sports Medicine (ACSM), providing a set of stretching exercises with illustrated instructions and advice against maintaining a single position for over 30 minutes.44,46
Education
Educational content was another core component of the DHIs in four trials, covering various topics such as ergonomics, sitting posture, pain anatomy and physiology, work-related mechanics, cognitive-behavioural strategies, and lifestyle changes.43–45,47 Education was delivered through videos (
Tailoring to individual needs
Two studies explicitly tailored interventions.45,47 Irvine et al. developed ‘FitBack’, a workplace DHI for LBP self-management categorising participants into job-based categories (sitters, drivers, lifters, and standers) and tailoring exercises and education accordingly. The framework, based on Social Cognitive Theory and the Theory of Planned Behaviour, allowed self-monitoring and module selection (Rest, Positive Thinking, Health Literacy, and Exercise), through classification algorithms that were undisclosed and unvalidated. Anan et al. used an AI-driven chatbot delivering tailored exercise interventions, allowing participants to select exercises and schedule messages, but did not clarify whether tailoring considered LBP characteristics or occupational demands.
While tailoring is suggested to enhance engagement and intervention relevance, its impact on outcomes remains unclear due to limited and inconsistent reporting. The remaining three studies provided generic interventions without tailoring them to individual needs. However, four studies incorporated work-specific intervention content, including ergonomic education addressing sedentary behaviour, 43 spine resilience in the workplace, 44 and exercises tailored to work activities 46 and occupation type. 47
Clinical outcome data
Clinical outcomes in the included studies were diverse, reflecting the multifaceted nature of LBP. Pain intensity was assessed in all five trials, with most using the Visual Analogue Scale (VAS),43–45 though one study did not specify the measurement tool. 47 Disability was evaluated in three trials using the Roland-Morris Disability Questionnaire (RMDQ) 43 and the Oswestry Disability Index (ODI).44,46 Risk of chronicity was reported in one study using the STarT Back Screening Tool (SBST). 43 Quality of life was measured in three studies using validated instruments such as the European Quality of Life 5 Dimensions 3L (EQ-5D-3L), 43 the Dartmouth Collaborative Primary Care Information Project (CO-OP), 47 and the Short-Form 12 (SF-12) Health Survey. 44 Physical performance was assessed in three trials, with objective laboratory-based measures evaluating lumbar endurance 43 and spinal mechanical function, 46 while one trial used the International Physical Activity Questionnaire (IPAQ). 44 Psychosocial outcomes were reported in two studies, measuring factors such as depression, anxiety, stress, and pain catastrophising using tools like the Tampa Scale for Kinesiophobia (TSK), 47 the Patient Activation Measure (PAM), and custom-designed questionnaires for self-efficacy and behavioural intentions. 47 Work performance was assessed in a single trial, utilising the Work Limitations Questionnaire (WLQ) and the Stanford Presenteeism Scale (SPS-6). 47 These outcomes highlight the broad range of measures used to capture the impact of DHIs on both clinical and workplace-specific aspects of LBP.
Intervention effects
Of the five trials, one study reported no adverse health effects of the intervention. 43 The remaining four studies did not disclose information on adverse events.44–47 Three studies reported participant adherence, with dropout rates in the intervention group ranging from 4.5% to 8%.43,44,47 Two studies reported high dropout in both the intervention (21.3%–50%) and the control groups (23.3%–60%).45,46 Only one study reported data on DHI usage, with an average of 6 minutes and 40 seconds per day. 44
Pain intensity
All five included trials assessed pain intensity as a primary outcome, with three using VAS of varying lengths.43–45 All trials reported a reduction in pain intensity, with three demonstrating statistically significant improvements.44,45,47 Irvine et al. reported a small and non-significant intervention effect for the tailored DHI compared to a non-tailored DHI (
Disability
Three trials identified LBP-related disability as a primary outcome. Two studies used the ODI,44,46 and one employed the RMDQ.
43
Del Pozo-Cruz et al. reported significant reductions in disability scores for participants using a DHI compared to standard occupational care (MD = –8.42, 95% CI: −9.76 to −7.07,
Quality of life
Three studies assessed the quality of life using validated tools: the EQ-5D-3L,
43
the SF-12,
44
and the CO-OP.
47
Almhdawi et al. reported significant improvements in physical health-related quality of life. Irvine et al. demonstrated enhanced quality of life improvements with a tailored DHI compared to a non-tailored DHI (
Physical performance
Three trials evaluated physical performance. Laboratory-based assessments in two trials found significant improvements in lumbar muscle endurance 43 and spinal mechanical function. 46 However, Almhdawi et al. reported no significant differences in physical activity levels, measured using the IPAQ. The authors did not specify whether they used the IPAQ short or long form and presented their findings as metabolic equivalents rather than categorical activity levels.
Psychosocial outcomes
Two trials investigated psychosocial factors such as stress, anxiety, depression, and pain catastrophizing.44,47 Irvine et al. observed significant benefits from the tailored DHI in self-efficacy, behavioural intentions, and a sense of responsibility for self-management. However, no significant differences were reported in pain catastrophizing (measured using the TSK). Almhdawi et al. found no group differences in sleep quality or mental health outcomes between a work-based DHI and a placebo DHI.
Risk of chronicity
Only one trial measured the risk of chronic LBP using the SBST.
43
This study found a significant increase in the proportion of participants classified as low risk of chronicity (37%,
Work performance
Only one trial evaluated work-related outcomes, using the 4-item WLQ and the SPS-6. 47 This study found no significant differences in work productivity or presenteeism between participants using tailored and non-tailored DHIs.
Discussion
This SR evaluated the effectiveness of workplace-based DHIs that support self-management of LBP on health and work outcomes, examined how these interventions are tailored to individual and occupational needs, and assessed their integration with workplace health pathways. Five randomised control studies met the inclusion criteria, evaluating pain intensity, disability, and physical performance as primary outcomes, and psychosocial factors, quality of life, and work-related measures such as sickness absence and presenteeism as secondary outcomes. Follow-ups ranged from 6 to 9 months, with three studies providing short-term follow-ups (6–12 weeks)44–46 and two offering mid-term (4–9 months).43,47 DHIs were delivered via web-based platforms43,47 or mobile apps,44–46 primarily through educational materials and exercise instructions in text, images, or videos. Four trials incorporated workplace-specific content, including exercises tailored to work activities46,47 or environments, 44 and ergonomic workplace education. 43
Evidence from the included trials suggests DHIs that support self-management of LBP provide low to moderate benefits for pain intensity, disability, and physical performance. This is consistent with previous reviews of DHIs for musculoskeletal conditions in clinical settings highlighting the effectiveness of combining education and exercise.29,30 Rathnayake et al. similarly reported moderate improvements in pain and disability in chronic LBP. However, the impact on quality of life, psychosocial factors, and work performance was mixed. One trial found improvements in self-management motivation and pain attitudes, 47 while another reported no significant effects on depression, anxiety, or stress. 44 These inconsistencies reflect broader literature that DHIs often fail to adequately address the complex psychosocial aspects of LBP.48,49
There was no consistent evidence of direct integration of DHIs into workplace health pathways, as interventions primarily focused on individual-level self-management rather than alignment with occupational health frameworks. None of the studies incorporated employer-driven occupational health services or policies, despite their recognised importance in the implementation and effectiveness of such interventions. 50
A recent SR by Blake et al. highlighted the benefits of workplace-based DHIs that support self-management of LBP on chronic pain management and access to work-related advice. 28 Integrating DHIs into occupational health systems could help organisations overcome barriers to early LBP self-management and provide a proactive approach to reducing absenteeism, ultimately easing the burden on healthcare services.51,52 Additionally, broader stakeholder engagement in the integration process is crucial to ensuring that DHIs meet the needs of working populations, enhancing their real-world impact. Underpinning designed interventions with appropriate theory and a logic model to guide the evaluation of health and work-related outcomes, including absenteeism and presenteeism, will be essential for advancing this field. 53
Despite some promising outcomes, the included studies presented considerable variability in participants’ job roles, demographics, and baseline LBP characteristics. Definitions of LBP vary considerably across studies, with pain durations ranging from 6 weeks to 9 months. Such inconsistencies complicate direct comparisons and generalisations, as individuals of different stages of pain may respond differently to DHIs. Heterogeneity also extended to methodological quality, with substantial variation in intervention content, outcome measures, and control group designs. Only two studies explicitly reported evidence-based DHI development,44,46 and few provided comprehensive details on intervention components. These reporting gaps, previously noted in systematic reviews, limiting the identification of effective workplace DHIs for LBP management.27,30 This aligns with broader critiques of DHI research, particularly in the lack of transparency, standardisation, and validation of tailoring models. 54
Tailored interventions were underrepresented, with only one trial 47 meeting the criteria by classifying participants based on job types and preferences. However, methodological weaknesses, including unvalidated outcome measures and potential funding bias, reduced its reliability. Validating classification models and tailoring algorithms is particularly crucial for improving the effectiveness of tailored interventions. The promising clinical effectiveness and adherence seen in recent AI-based DHIs that support self-management of LBP suggest that AI may enhance classification accuracy for better-tailored interventions.55–57 Workplace LBP data could play a key role in training AI models, while AI-based DHIs also offer the potential for enhancing organisational-level LBP management. The high accuracy of a recent AI-driven LBP classification model by Liu et al. highlights its potential advancing tailored workplace interventions by personalising ergonomics and exercise programmers based on an individual's spine function signature. 58
Workplace-specific interventions often perform differently across occupations due to variations in physical demands, ergonomic risks, and resource access,16,59 highlighting the need for context-sensitive approaches. The inconsistent tailoring methods across studies further reflect broader gaps in standardised intervention design and evaluation.29,60 Future research should adopt standardised frameworks, such as the Medical Research Council (MRC) framework for complex health interventions, 53 to ensure rigor in DHI development and evaluation.
Certain limitations hinder interpretation, including short follow-up durations, limiting understanding of long-term effects, and insufficient stakeholder involvement, which could enhance intervention relevance and feasibility. While imaging is not routinely recommended for uncomplicated LBP diagnosis, 17 its absence may obscure the identification of specific underlying mechanisms. These limitations underscore the need for more uniform inclusion criteria and the potential incorporation of objective classification tools in future research, to enhance comparability and better delineate the effectiveness of DHIs supporting self-management in LBP populations. Additionally, the lack of detailed intervention descriptions and development processes highlights the need for comprehensive reporting, including Supplemental Material. Future research should therefore prioritise standardised frameworks, occupational health collaboration, and longer follow-ups to assess levels of integration and sustained impacts. Validating tailoring methods and aligning DHIs with workplace policies are essential for maximising their effectiveness in workplace LBP management.
Conclusion
Despite the limited research on DHIs that support self-management for workplace LBP, this systematic review suggests their potential to improve pain intensity, disability, and physical performance. However, their effectiveness on psychosocial factors, quality of life, and work-related outcomes (e.g., sickness absence and presenteeism) remains inconsistent, likely due to a greater focus on individual rather than organisational-level factors, limited tailoring to individual and occupational needs, and minimal integration into workplace health systems. Addressing these gaps through validated tailoring models, standardised intervention frameworks, and stronger alignment with occupational health policies is essential to enhance scalability, engagement, and long-term impact in workplace LBP management.
Supplemental Material
sj-docx-1-dhj-10.1177_20552076251336281 - Supplemental material for Systematic review of digital health interventions to support self-management of low back pain in the workplace
Supplemental material, sj-docx-1-dhj-10.1177_20552076251336281 for Systematic review of digital health interventions to support self-management of low back pain in the workplace by Minghao Chen, Valerie Sparkes and Liba Sheeran in DIGITAL HEALTH
Supplemental Material
sj-docx-2-dhj-10.1177_20552076251336281 - Supplemental material for Systematic review of digital health interventions to support self-management of low back pain in the workplace
Supplemental material, sj-docx-2-dhj-10.1177_20552076251336281 for Systematic review of digital health interventions to support self-management of low back pain in the workplace by Minghao Chen, Valerie Sparkes and Liba Sheeran in DIGITAL HEALTH
Footnotes
Ethical considerations
Institutional review board approval was not required as this article was systematic
review of the literature and not original research.
Author contributions/CRediT
MC: study design, data collection and processing, data analysis, manuscript drafting, and figure design. LS: study design, data analysis and interpretation, manuscript drafting and revision, and conceptual input. VS: supervision, analytical guidance, results interpretation, and manuscript review and feedback.
Funding
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was sponsored by the China Scholarship Council (grant number 202008060334).
Conflicting interests
The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Supplemental material
Supplemental material for this article is available online.
References
Supplementary Material
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