Hepatocellular Carcinoma (HCC) is rising in incidence worldwide, especially in areas endemic for chronic viral hepatitis. Distant metastases are common especially in lungs and bones. Subcutaneous or mucosal metastases, however, are rare. We report a case of both mucosal and subcutaneous metastases in the same patient.
FerlayJSoerjomataramIErvikMFormanDBrayFDikshitR. GLOBOCAN 2012: Estimated cancer incidence, mortality and prevalence worldwide in 2012 [Internet]. Lyon: International Agency for Research on Cancer; 2013 Dec 12 [updated 2014 Jan 9; cited 2014 Jul 15]. Available from: http://globocan.iarc.fr.
2.
AngSFTanSHTohHCPoonDYOngSYFooKF. Activity of thalidomide and capecitabine in patients with advanced hepatocellular carcinoma. Am J Clin Oncol2012;35(3):222–7 doi: 10.1097/COC.0b013e31820dbf56.
3.
National Registry of Diseases Office. Singapore cancer registry [Internet]. Singapore: Ministry of Health, National Registry of Diseases Office; 2008 [updated 2014 Jun 30; cited 2014 Jul 15]. Available from: https://www.nrdo.gov.sg/page.aspx?id=76.
4.
TeradaTMasuoH. Unusual extrahepatic metastatic sites from hepatocellular carcinoma. Int J Clin Exp Pathol2013;6(5):816–20.
5.
KuoI-JChenP-RHsuY-H. Gingival metastasis of primary hepatocellular carcinoma — case report. Tzu Chi Med J2006;18(2):145–7.
6.
PiresFRSagarraRCorreaMEPereiraCMVargasPALopesMA. Oral metastasis of a hepatocellular carcinomaOral Surg Oral Med Oral Pathol Oral Radiol Endod2004;97(3):359–68 doi: 10.1016/j.tripleo.2003.09.018.
7.
YuYDKimDSJungSWLeeJHChaeYSSuhSO. Metastatic hepatocellular carcinoma to the parotid gland: Case report and review of the literature. Int J Surg Case Rep2013;4(1):76–80 doi: 10.1016/j.ijscr.2012.08.018.
8.
RuebenSOwenDLeePWeissA. Hepatocellular carcinoma with cutaneous metastases. Can J Gastroenterol2009;23(1):23–5.
9.
de AgustinPCondeEAlbertiNPerez-BarriosALopez-RiosF. Cutaneous metastasis of occult hepatocellular carcinoma: A case report. Acta Cytol2007;51(2):214–6 doi: 10.1159/000325720.
10.
Al-MashatFM. Hepatocellular carcinoma with cutaneous metastasis. Saudi Med J2004;25(3):370–2.
11.
AppenzellerJWeitznerSLongGW. Hepatocellular carcinoma metastatic to the mandible: Report of case and review of literature. J Oral Surg1971;29(9):668–71.
12.
BatsonOV. The function of the vertebral veins and their role in the spread of metastases.1940. Clin Orthop Relat Res1995;(312):4–9.
13.
RamirezJ RamonSeoaneJMonteroJGomezGC EsparzaCereroR. Isolated gingival metastasis from hepatocellular carcinoma mimicking a pyogenic granuloma. J Clin Periodontol2003;30(10):926–9 doi: 10.1034/j.1600-051X.2003.00391.x.
14.
JunqueraLRodríguez-RecioCTorreASanchez-MayoralJFresnoMF. Hepatocellular carcinoma metastatic to the mandible: A case involving severe haemorrhageMed Oral2004;9(4):345–9.
15.
WalterCMKirbyEJVasconezHCRinkerBD. Hepatocellular carcinoma metastatic to the scalp. J Craniofac Surg2011;22(2):720–1 doi: 10.1097/SCS.0b013e3182077843.
16.
HuangYJTungWCHsuHCWangCYHuangEYFangFM. Radiation therapy to non-iatrogenic subcutaneous metastasis in hepatocellular carcinoma: Results of case series. Br J Radiol2008;81(962):143–50 doi: 10.1259/bjr/81811976.