The correlation of adiponectin,high-sensitivity C-reactive protein,and adiponectin/CRP ratio to Castelli risk Index-II in cardiovascular disease associated with vitamin-D deficiency in laboratory workers at M. Djamil Public Hospital,West Sumatra

Abstract

Background: Vitamin-D sufficiency is essential to maintain the physiological functions of the body such as intestinal calcium absorption for optimal skeletal health, but recently, several studies have stated that vitamin-D deficiency results in poor non-skeletal outcomes such as chronic inflammation and atherogenicity. Objective: This study aims to investigate the correlation of adiponectin, high-sensitivity C-reactive protein (hs-CRP), and adiponectin/CRP ratio to Castelli risk index-II (CRI-II) in cardiovascular disease (CVD) associated with vitamin-D deficiency in laboratory workers. Methods: Analytical research using a cross-sectional design on 59 laboratory workers with vitamin-D deficiency was used. The hs-CRP levels, 25-hydroxy vitamin-D [25(OH)D] total, and adiponectin, were measured using the enzyme-linked immunosorbent assay (ELISA). The Friedewald formula was used to calculate LDL-C quantities indirectly, while the homogeneous enzymatic colorimetric method was used to calculate the HDL-C quantities. Results: The mean of adiponectin, hs-CRP, LDL-C, HDL-C, and CRI-II were 4.38 (2.51) μg/mL, 4.17 (2.86) mg/L, 121.8 (30.1) mg/dL, 47.9 (11.0) mg/dL, and 2.7 (0.9), respectively, and the median quantity of adiponectin/CRP ratio was 1.2 (0.2–47.0). The adiponectin and adiponectin/CRP ratio values demonstrated high correlation values in the negative direction (r = −0.502, p = 0.000) and had a weak negative correlation (r = −0.364, p = 0.005) with CRI-II, respectively, while hs-CRP did not correspond with CRI-II (r = 0.167, p = 0.206). Conclusion: Adiponectin was discovered to be the most correlated parameter with CRI-II, as evidenced by the results of the linear regression analysis. Adiponectin was the only parameter correlating with CRI-II in CVD associated with vitamin-D deficiency.