A 65-year-old woman underwent MRI for a mild cognitive impairment (MCI) at Mini-Mental State Examination (MMSE). MRI showed hippocampal sulcus remnants bilaterally, although they were larger on the right, and left hippocampal atrophy with increased left fimbrio-subicular distance (right side: 1.2 mm; left side: 2.0 mm). The meaning of these findings in relation to clinical aspects is discussed and reviewed according to data from the literature.
WolfHGrunwaldMKruggelF. Hippocampal volume discriminates between normal cognition; questionable and mild dementia in the elderly. Neurobiol Aging.2001; 22: 177–186.
2.
GeuzeEVermettenEBremnerJD. MR-based in vivo hippocampal volumetrics: 2. Findings in neuropsychiatric disorders. Mol Psychol.10: 2005; 160–184.
3.
Bastos-LeiteAJvan WaesbergheJHOenAL. Hippocampal sulcus width and cavities: Comparison between patients with Alzheimer disease and nondemented elderly subjects. Am J Neuroradiol.27: 2006; 2141–2145.
4.
BarberRMcKeithIGBallardC. A comparison of medial and lateral temporal lobe atrophy in dementia with Lewy bodies and Alzheimer's disease: Magnetic resonance imaging volumetric study. Dement Geriatr Cogn Disord.12: 2001; 198–205.
5.
ColliotOlivierChetelatGaelChupinMarie. Discrimination between Alzheimer disease, mild cognitive impairment, and normal aging by using automated segmentation of the hippocampus. Radiology.2008; 248: 194–201.
6.
ConvitAde LeonMJGolombJ: Hippocampal atrophy in early Alzheimer's disease: Anatomic specificity and validation. Psychiatr Q.1993; 64: 37–387.
7.
De LeonMJGeorgeAEGolombJ. Frequency of hippocampal formation atrophy in normal aging and Alzheimer's disease. Neurobiol Aging.1997; 18: 1–11.
8.
SasakiMSoneMEharaS. Hippocampal sulcus remnant: Potential cause of change in signal intensity in the hippocampus. Radiology.1993; 188: 743–746.
9.
KweeRobert M.KweeThomas C., Virchow-Robin at MR imaging. RadioGraphics.2007; 27: 1071–1086.
10.
MaclullichAMWardlawJMFergusonKJ: Enlarged perivascular spaces are associated with cognitive function in healthy elderly men. J Neurol Neurosurg Psychiatry.2004; 75: 1519–1523.
11.
SasakiMSoneMEharaS. Hippocampal sulcus remnant: Potential cause of change in signal intensity in the hippocampus. Radiology.1993; 188: 743–746.
12.
BarboriakDPDoraiswamyPMKrishnanKR. Hippocampal sulcal cavities on MRI: Relationship to age and apolipoprotein E genotype. Neurology.2000; 54: 2150–2153.
13.
ScheltensPLeysDBarkhofF. Atrophy of medial temporal lobes on MRI in “probable” Alzheimer's disease and normal ageing: Diagnostic value and neuropsychological correlates. J Neurol Neurosurg Psychiatry.1992; 55: 967–972.
14.
LeiteAJ BastosScheltensPBarkhofF. Pathological aging of the brain: An overview. Top Magn Reson Imaging.2004; 15: 369–389.
15.
HoneycuttNASmithCD. Hippocampal volume measurements using magnetic resonance imaging in normal young adults. J Neuroimaging.1995; 5: 95–100.
16.
GeuzeEVermettenEBremnerJD. MR-based in vivo hippocampal volumetrics: 1. Review of methodologies currently employed. Mol Psychol.2005; 10: 147–159.
17.
de Toledo-MorrellLDickersonBSullivanMP. Hemispheric differences in hippocampal volume predict verbal and spatial memory performance in patients with Alzheimer's disease. Hippocampus.2000; 10: 136–142.
18.
FoxNCWarringtonEKFreeboroughPA. Presymptomatic hippocampal atrophy in Alzheimer's disease. A longitudinal MRI study. Brain.1996; 119: 2001–2007.
19.
LaaksoMPPartanenKRiekkinenP. Hippocampal volumes in Alzheimer's disease, Parkinson's disease with and without dementia, and in vascular dementia: An MRI study. Neurology.1996; 46: 678–681.