Orthobiologics continues to advance in medicine due to its regenerative capabilities. In fact, there is a vast indication of use with regenerative medicine options such as platelet-rich plasma (PRP) and bone marrow aspirate concentrate (BMAC) within the human body for various musculoskeletal conditions. While both options are different, the purpose of each is to promote a natural healing response with specific growth factors, proteins, or cells to aid in this. In this concept review, we present a current update on the literature surrounding these regenerative medicine options specifically with utilization in the foot and the ankle. We have found in our practice that regenerative medicine options offer our patients a nonoperative as well as operative biologic supplemental option for treatment on various foot and ankle conditions with relatively high success rates and overall high patient satisfaction. We hope this review educates the foot and ankle surgeon on this rapidly evolving treatment to enhance patient outcomes and improve quality of care.
ShapiroSAMasterZArthursJRMautnerK.Tiered approach to considering orthobiologics for patients with musculoskeletal conditions. Br J Sports Med. 2023;57(3):179-180. doi:10.1136/bjsports-2022-106494
2.
BerlinbergEJSwindellHPatelHH, et al. The epidemiology of platelet-rich plasma injections from 2010 to 2020 in a large US commercial insurance claims database: a recent update. J Am Acad Orthop Surg. 2023;31(3):e135-e147. doi:10.5435/JAAOS-D-22-00397
3.
BeitzelKAllenDApostolakosJ, et al. US definitions, current use, and FDA stance on use of platelet-rich plasma in sports medicine. J Knee Surg. 2015;28(1):29-34. doi:10.1055/s-0034-1390030
4.
JildehTRSuCAVopatMLBrownJRHuardJ.A review of commercially available point-of-care devices to concentrate platelet-rich plasma. Cureus. 2022;14(8):e28498. doi:10.7759/cureus.28498
5.
KiaCBaldinoJBellRRamjiAUyekiCMazzoccaA.Platelet-rich plasma: review of current literature on its use for tendon and ligament pathology. Curr Rev Musculoskelet Med. 2018;11(4):566-572. doi:10.1007/s12178-018-9515-y
6.
MiglioreAProcopioS.Effectiveness and utility of hyaluronic acid in osteoarthritis. Clin Cases Miner Bone Metab. 2015;12(1):31-33. doi:10.11138/ccmbm/2015.12.1.031
7.
DuDLiangY.A meta-analysis and systematic review of the clinical efficacy and safety of platelet-rich plasma combined with hyaluronic acid (PRP + HA) versus PRP monotherapy for knee osteoarthritis (KOA). J Orthop Surg Res. 2025;20:57. doi:10.1186/s13018-024-05429-w
8.
RossoCMorreyMESchärMOGrezdaK.The role of platelet-rich plasma in shoulder pathologies: a critical review of the literature. EFORT Open Rev. 2023;8(4):2132-2122. doi:10.1530/EOR-22-0104
9.
Rodríguez-MerchánEC.Intra-articular platelet-rich plasma injections in knee osteoarthritis: a review of their current molecular mechanisms of action and their degree of efficacy. Int J Mol Sci. 2022;23(3):1301. doi:10.3390/ijms23031301
10.
BelkJWKraeutlerMJHouckDAGoodrichJADragooJLMcCartyEC.Platelet-rich plasma versus hyaluronic acid for knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials. Am J Sports Med. 2021;49(1):249-260. doi:10.1177/0363546520909397
11.
FilardoGPrevitaliDNapoliFCandrianCZaffagniniSGrassiA.PRP injections for the treatment of knee osteoarthritis: a metaanalysis of randomized controlled trials. Cartilage. 2021;13:364S-375S. doi:10.1177/1947603520931170
12.
ParkYBKimJHHaCWLeeDH.Clinical efficacy of platelet-rich plasma injection and its association with growth factors in the treatment of mild to moderate knee osteoarthritis: a randomized double blind controlled clinical trial as compared with hyaluronic acid. Am J Sports Med. 2021;49(2):487-496. doi:10.1177/0363546520986867
13.
ColeBJSeroyerSTFilardoGBajajSFortierLA.Platelet-rich plasma: where are we now and where are we going. Sports Health. 2010;2(3):203-210.
14.
BoswellSGColeBJSundmanEAKarasVFortierLA.Platelet-rich plasma: a milieu of bioactive factors. Arthroscopy. 2012;28(3):429-439. doi:10.1016/j.arthro.2011.10.018
15.
MarxRE.Platelet-rich plasma: evidence to support its use. J Oral Maxillofac Surg. 2004;62:489-496. doi:10.1016/j.joms.2003.12.003
16.
PavlovicVCiricMJovanovicVStojanovicP.Platelet rich plasma: a short overview of certain bioactive components. Open Med. 2016;11(1):242-247. doi:10.1515/med-2016-0048
17.
BerriganWABailowitzZParkAReddyALiuRLansdownD.A greater platelet dose may yield better clinical outcomes for platelet-rich plasma in the treatment of knee osteoarthritis: a systematic review. Arthroscopy. 2024;41:809-817.
18.
XieXZhangCTuanRS.Biology of platelet-rich plasma and its clinical application in cartilage repair. Arthritis Res Ther. 2014;16(1):204. doi:10.1186/ar4493
19.
KleinDBloomDCampbellK, et al. Alpha-2-macroglobulin not significantly better than regular PRP for knee arthritis symptoms. Orthop J Sports Med. 2020;8(7 suppl 6):2325967120S00454. doi:10.1177/2325967120S00454
20.
ThompsonKShankarDSHuangS, et al. The effectiveness of alpha-2-macroglobulin injections for osteoarthritis of the knee. Bull Hosp Jt Dis. 2024;82(4):245-256.
21.
BoffaASalernoMMerliG, et al. Platelet-rich plasma injections induce disease-modifying effects in the treatment of osteoarthritis in animal models. Knee Surg Sports Traumatol Arthrosc. 2021;29(12):4100-4121. doi:10.1007/s00167-021-06659-9
22.
JayaramPMitchellPJTShybutTBMoseleyBJLeeB.Leukocyte-rich platelet-rich plasma is predominantly anti-inflammatory compared with leukocyte-poor platelet-rich plasma in patients with mild-moderate knee osteoarthritis: a prospective, descriptive laboratory study. Am J Sports Med. 2023;51(8):2133-2140. doi:10.1177/03635465231170394
23.
MartinPLeibovichSJ.Inflammatory cells during wound repair: the good, the bad and the ugly. Trends Cell Biol. 2005;15(11):599-607. doi:10.1016/j.tcb.2005.09.002
24.
McCarrelTMMinasTFortierLA.Optimization of leukocyte concentration in platelet-rich plasma for the treatment of tendinopathy. J Bone Joint Surg Am. 2012;94:e143. doi:10.2106/JBJS.L.00019
25.
McCarrelTFortierL.Temporal growth factor release from platelet-rich plasma, trehalose lyophilized platelets, and bone marrow aspirate and their effect on tendon and ligament gene expression. J Orthop Res. 2009;27:1033-1042. doi:10.1002/jor.20853
26.
Di MartinoABoffaAAndrioloL, et al. Leukocyte-rich versus leukocyte-poor platelet-rich plasma for the treatment of knee osteoarthritis: a double-blind randomized trial. Am J Sports Med. 2022;50(3):609-617. doi:10.1177/03635465211064303
27.
GuptaAJeyaramanMPottyAG.Leukocyte-rich vs. Leukocyte-poor platelet-rich plasma for the treatment of knee osteoarthritis. Biomedicines. 2023;11(1):141. doi:10.3390/biomedicines11010141
28.
YuanZWangYLiY, et al. Comparison of leukocyte-rich and leukocyte-poor platelet-rich plasma on pressure ulcer in a rat model. J Burn Care Res. 2023;44(4):860-868. doi:10.1093/jbcr/irac191
29.
LanaJFHuberSCPuritaJ, et al. Leukocyte-rich PRP versus leukocyte-poor PRP—the role of monocyte/macrophage function in the healing cascade. J Clin Orthop Trauma. 2019;10(suppl 1):S7-S12. doi:10.1016/j.jcot.2019.05.008
30.
DalyME.Determinants of platelet count in humans. Haematologica. 2011;96(1):10-13. doi:10.3324/haematol.2010.035287
31.
BansalHLeonJPontJL, et al. Platelet-rich plasma (PRP) in osteoarthritis (OA) knee: correct dose critical for long term clinical efficacy. Sci Rep. 2021;11:3971. doi:10.1038/s41598-021-83025-2
32.
NouriFBabaeeMPeydayeshPEsmailyHRaeissadatSA.Comparison between the effects of ultrasound guided intra-articular injections of platelet-rich plasma (PRP), high molecular weight hyaluronic acid, and their combination in hip osteoarthritis: a randomized clinical trial. BMC Musculoskelet Disord. 2022;23(1):856. doi:10.1186/s12891-022-05787-8
33.
ZaffagniniSAndrioloLBoffaA, et al. Microfragmented adipose tissue versus platelet-rich plasma for the treatment of knee osteoarthritis: a prospective randomized controlled trial at 2-year follow-up. Am J Sports Med. 2022;50(11):2881-2892. doi:10.1177/03635465221115821
34.
AnzAWPlummerHACohenAEvertsPAAndrewsJRHackelJG.Bone marrow aspirate concentrate is equivalent to platelet-rich plasma for the treatment of knee osteoarthritis at 2 years: a prospective randomized trial. Am J Sports Med. 2022;50(3):618-629. doi:10.1177/03635465211072554
35.
RossiLRanallettaMPasqualiniI, et al. Substantial variability in platelet-rich plasma composition is based on patient age and baseline platelet count. Arthrosc Sports Med Rehabil. 2023;5(3):e853-e858. doi:10.1016/j.asmr.2023.03.017
36.
HarrisonTEBowlerJLevinsTNReevesKD.PRPCalc2: an app for platelet-rich plasma preparation. Cureus. 2023;15(3):e36099. doi:10.7759/cureus.36099
37.
KitamuraYSuzukiMTsukiokaT, et al. Spectrophotometric determination of platelet counts in platelet-rich plasma. Int J Implant Dent. 2018;4:29. doi:10.1186/s40729-018-0140-8
38.
KikuchiNYoshiokaTTaniguchiY, et al. Optimization of leukocyte-poor platelet-rich plasma preparation: a validation study of leukocyte-poor platelet-rich plasma obtained using different preparer, storage, and activation methods. J Exp Ortop. 2019;6:24. doi:10.1186/s40634-019-0190-8
39.
ConnollyJGuseRLippielloLDehneR.Development of an osteogenic bone marrow preparation. J Bone Joint Surg Am. 1989;71(5):684-691.
40.
HyerCFBerletGCBussewitzBW, et al. Quantitative assessment of the yield of osteoblastic connective tissue progenitors in bone marrow aspirate from the iliac crest, tibia, and calcaneus. J Bone Joint Surg A. 2013;95(14):1312-1316.
41.
CaplanAI.Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. J Cell Physiol. 2007;213(2):341-347.
42.
DiGiovanniCWLinSSBaumhauerJF, et al. Recombinant human platelet derived growth factor-BB and beta-tricalcium phosphate (rhPDGF-BB/beta-TCP): an alternative to autogenous bone graft. J Bone Joint Surg Am. 2013;95(13):1184-1192.
43.
FreyCHalikusNMVu-RoseTEbramzadehE.A review of ankle arthrodesis: predisposing factors to nonunion. Foot Ankle Int. 1994;15(11):581-584.
44.
EasleyMETrnkaHJSchonLC, et al. Isolated subtalar arthrodesis. J Bone Joint Surg Am. 2000;82(5):613-624.
45.
O’ConnorKMJohnsonJEMcCormickJJKleinSE.Clinical and operative factors related to successful revision arthrodesis in the foot and ankle. Foot Ankle Int. 2016;37(8):809-815.
46.
JiaXPetersPGSchonL, et al. The use of platelet-rich plasma in the management of foot and ankle conditions. Oper Tech Sports Med. 2011;19:177-184.
47.
SchepullTKvistJNorrmanH.Autologous platelets have no effect on the healing of human Achilles tendon ruptures: a randomized single-blind study. Am J Sports Med. 2011;39:38-47.
48.
YamaguchiYKuboTMurakamiT, et al. Bone marrow cells differentiate into wound myofibroblasts and accelerate the healing of wounds with exposed bones when combined with an occlusive dressing. Br J Dermatol. 2005;152(4):616-622.
49.
HernigouPHMathieuGPoignardA, et al. Percutaneous autologous bone marrow grafting for nonunions: surgical technique. J Bone Joint Surg. 2006;88-A(suppl 1):322-327.
50.
ChongAAngAGohJ, et al. Bone marrow derived mesenchymal stem cells influence early tendon-healing in a rabbit Achilles tendon model. J Bone Joint Surg. 2007;89(1):74-81.
51.
MuschlerGBoehmCEasleyK.Aspiration to obtain osteoblast progenitor cells from human bone marrow: the influence of aspiration volume. J Bone Joint Surg. 1997;79-A(11):1699-1709.
52.
LiCKilpatrickCDSmithS, et al. Assessment of multipotent mesenchymal stromal cells in bone marrow aspirate from human calcaneus. J Foot Ankle Surg. 2017;56(1):42-46.
53.
SugayaHYoshiokaTKatoT, et al. Comparative analysis of cellular and growth factor composition in bone marrow aspirate concentrate and platelet-rich plasma. Bone Marrow Res. 2018;2018:1549826. doi:10.1155/2018/1549826
54.
GlennRJohnsWWalleyKJacksonJB3rdGonzalezT.Topical review: bone marrow aspirate concentrate and its clinical use in foot and ankle surgery. Foot Ankle Int. 2021;42(9):1205-1211. doi:10.1177/10711007211021017
55.
CottomJMPlemmonsBS.Bone marrow aspirate concentrate and its uses in the foot and ankle. Clin Podiatr Med Surg. 2018;35(1):19-26.
56.
CaradonnaEMormoneECentrittoEM, et al. Different methods of bone marrow harvesting influence cell characteristics and purity, affecting clinical outcomes. JVS Vasc Sci. 2023;4:100130.
57.
ThemistocleousGSChlorosGDKyrantzoulisIM, et al. Effectiveness of a single intra-articular bone marrow aspirate concentrate (BMAC) injection in patients with grade 3 and 4 knee osteoarthritis. Heliyon. 2018;4(10):e00871. doi:10.1016/j.heliyon.2018.e00871
58.
KueblerDSchneeAMooreL, et al. Short-term efficacy of using a novel low-volume bone marrow aspiration technique to treat knee osteoarthritis: a retrospective cohort study. Stem Cells Int. 2022;2022:5394441. doi:10.1155/2022/5394441
59.
ViganòMRagniEDi MatteoB, et al. A single-step, centrifuge-free method to harvest bone marrow highly concentrated in mesenchymal stem cells: results of a pilot trial. Int Orthop. 2021;46(1):391-400.
60.
VaradyNHCateGBarghiA, et al. Positive early clinical outcomes of bone marrow aspirate concentrate for osteoarthritis using a novel fenestrated trocar. Knee. 2020;27(5):1627-1634.
61.
ScarponeMKueblerDChambersA, et al. Isolation of clinically relevant concentrations of bone marrow mesenchymal stem cells without centrifugation. J Transl Med. 2019;17:10. doi:10.1186/s12967-018-1750-x
62.
EasleyJTSikesKJBisazzaKMeyersMStewartHLRevesB.Preclinical Evaluation of Marrow Cellution Needle Compared to Traditional Aspiration and BioCUE Centrifugation System. Colorado State University; 2023.
63.
FriedlisMFCentenoCJ.Performing a better bone marrow aspiration. Phys Med Rehabil Clin N Am. 2016;27(4):919-939. doi:10.1016/j.pmr.2016.06.009
64.
BachirRMZaiaIMSantosGS, et al. Bone marrow aspirate concentrate improves outcomes in adults with osteochondral dissecans of the talus and Achilles rupture. Arthroscopy. 2023;39(3):881-886. doi:10.1016/j.arthro.2022.11.034
65.
KarzonALKadakiaRJColemanMMBariteauJTLabibSA.The rise of total ankle arthroplasty use: a database analysis describing case volumes and incidence trends in the united states between 2009 and 2019. Foot Ankle Int. 2022;43(11):1501-1510. doi:10.1177/10711007221119148
66.
PagetLDAReurinkGde VosR, et al. Effect of platelet-rich plasma injections vs placebo on ankle symptoms and function in patients with ankle osteoarthritis: a randomized clinical trial. JAMA. 2021;326(16):1595-1605. doi:10.1001/jama.2021.16602
67.
PagetLDAReurinkGde VosRJ, et al. Platelet-rich plasma injections for the treatment of ankle osteoarthritis. Am J Sports Med. 2023;51(10):2625-2634. doi:10.1177/03635465231182438
68.
RepettoIBitiBCerrutiPTrentiniRFelliL.Conservative treatment of ankle osteoarthritis: can platelet-rich plasma effectively postpone surgery. J Foot Ankle Surg. 2017;56(2):362-365.
69.
SunSFHsuCWLinGC, et al. Efficacy and safety of a single intra-articular injection of platelet-rich plasma on pain and physical function in patients with ankle osteoarthritis—a prospective study. J Foot Ankle Surg. 2021;60(4):676-682.
70.
GuneyAYurdakulEKaramanIBilalOKafadarIHOnerM.Medium-term outcomes of mosaicplasty versus arthroscopic microfracture with or without platelet-rich plasma in the treatment of osteochondral lesions of the talus. Knee Surg Sports Traumatol Arthrosc. 2016;24(4):1293-1298. doi:10.1007/s00167-015-3834-y
71.
EvansAIbrahimMPopeR, et al. Treating hand and foot osteoarthritis using a patient’s own blood: a systematic review and meta-analysis of platelet-rich plasma. J Orthop. 2020;18:226-236. doi:10.1016/j.jor.2020.01.037
72.
FortierLABarkerJUStraussEJMcCarrelTMColeBJ.The role of growth factors in cartilage repair [review]. Clin Orthop Relat Res. 2011;469(10):2706-2715.
73.
WehlingPMoserCFrisbieD, et al. Autologous conditioned serum in the treatment of orthopaedic diseases: the orthokine therapy. Biodrugs. 2007;21:323-332.
74.
SawKYHussinPLokeSC, et al. Articular cartilage regeneration with autologous marrow aspirate and hyaluronic acid: an experimental study in a goat model. Arthroscopy. 2009;25(12):1391-1400.
75.
FortierLAPotterHGRickeyEJ, et al. Concentrated bone marrow aspirate improves full-thickness cartilage repair compared with microfracture in the equine model. J Bone Joint Surg Am. 2010;92(10):1927-1937.
76.
DominiciMLe BlancKMuellerI, et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The international society for cellular therapy position statement. Cytotherapy. 2006;8(4):315-317.
77.
LanhamNSCarrollJJCooperMT, et al. A comparison of outcomes of particulated juvenile articular cartilage and bone marrow aspirate concentrate for articular cartilage lesions of the talus. Foot Ankle Spec. 2016;10(4):315-321.
78.
HoltonJImamMWardJ, et al. The basic science of bone marrow aspirate concentrate in chondral injuries. Orthop Rev. 2016;8(3):6659.
79.
ChahlaJCinqueMEShonJM, et al. Bone marrow aspirate concentrate for the treatment of osteochondral lesions of the talus: a systematic review of outcomes. J Exp Orthop. 2016;3(1):33.
80.
ClantonTOJohnsonNSMathenyLM.Use of cartilage extracellular matrix and bone marrow aspirate concentrate in treatment of osteochondral lesions of the talus. Tech Foot Ankle Surg. 2014;13(4):212-220.
81.
WeberMNiemannMLanzRMüllerT.Nonoperative treatment of acute rupture of the Achilles tendon: results of a new protocol and comparison with operative treatment. Am J Sports Med. 2003;31(5):685-691. doi:10.1177/03635465030310050901
82.
CohenDSandmanESaranN, et al. Evidence-based treatment of Achilles tendon rupture. Can J Surg. 2023;66(4):E356-E357. doi:10.1503/cjs.008321
83.
CrookBSVarshneyaKMeyerLEAnastasioACullenMMLauBC.Operative versus nonoperative treatment of acute Achilles tendon rupture: a propensity score-matched analysis of a large national dataset. Orthop J Sports Med. 2023;11(2):23259671231152904. doi:10.1177/23259671231152904
84.
WillitsKAmendolaABryantD, et al. Operative versus nonoperative treatment of acute Achilles tendon ruptures: a multicenter randomized trial using accelerated functional rehabilitation. J Bone Joint Surg Am. 2010;92(17):2767-2775. doi:10.2106/JBJS.I.01401
85.
QiXZhengDLeiZYuJQiuXChenY.Clinical outcome of Achilles tendon rupture repaired by a modified minimally invasive percutaneous suturing. Orthop Res Rev. 2025;17:21-29.
86.
YükselSAdanırOGültekinMZ, et al. Effect of platelet-rich plasma for treatment of Achilles tendons in free-moving rats after surgical incision and treatment. Acta Orthop Traumatol Turc. 2015;49(5):544-551.
LyrasDNKazakosKGeorgiadisG, et al. Does a single application of PRP alter the expression of IGF-I in the early phase of tendon healing. J Foot Ankle Surg. 2011;50(3):276-282.
89.
BoesenAPBoesenMIHansenR, et al. Effect of platelet-rich plasma on nonsurgically treated acute Achilles tendon ruptures: a randomized, double-blinded prospective study. Am J Sports Med. 2020;48(9):2268-2276. doi:10.1177/0363546520922541
90.
KeeneDJAlsousouJHarrisonP, et al. Platelet-rich plasma injection for acute Achilles tendon rupture. Bone Joint J. 2022;104-B(11):1256-1265. doi:10.1302/0301-620X.104B11.BJJ-2022-0653.R1
91.
BokshKElbashirMThomasODivallPMangwaniJ.Platelet-rich plasma in acute Achilles tendon ruptures: a systematic review and meta-analysis. Foot. 2022;53:101923. doi:10.1177/2473011421S00549
92.
YukselSGuleçMAGultekinMZ, et al. Comparison of the early period effects of bone marrow-derived mesenchymal stem cells and platelet-rich plasma on the Achilles tendon ruptures in rats. Connect Tissue Res. 2016;57(5):360-373.
93.
LaverLCarmontMRMcConkeyMO, et al. Plasma rich in growth factors (PRGF) as a treatment for high ankle sprain in elite athletes: a randomized control trial. Knee Surg Sports Traumatol Arthrosc. 2015;23(11):3383-3392. doi:10.1007/s00167-014-3119-x
94.
ZhangJWangCLiXFuSGuWShiZ.Platelet-rich plasma, a biomaterial, for the treatment of anterior talofibular ligament in lateral ankle sprain. Front Bioeng Biotechnol. 2022;10:1073063. doi:10.3389/fbioe.2022.1073063
95.
Blanco-RiveraJElizondo-RodríguezJSimental-MendíaMVilchez-CavazosFPeña-MartínezVMAcosta-OlivoC.Treatment of lateral ankle sprain with platelet-rich plasma: a randomized clinical study. Foot Ankle Surg. 2020;26(7):750-754.
96.
Medina-PorqueresIMartin-GarciaPSanz-De-DiegoS, et al. Platelet-rich plasma injections in chronic lateral ankle instability: a case series. Biomedicines. 2024;12(5):963. doi:10.3390/biomedicines12050963
WheelerPBoydKShiptonM.Surgery for patients with recalcitrant plantar fasciitis: good results at short-, medium-, and long-term follow-up. Orthop J Sports Med. 2014;2(3):2325967114527901. doi:10.1177/2325967114527901
99.
YuanYQianYLuH, et al. Comparison of the therapeutic outcomes between open plantar fascia release and percutaneous radiofrequency ablation in the treatment of intractable plantar fasciitis. J Orthop Surg Res. 2020;15:55. doi:10.1186/s13018-020-1582-2
100.
HaddadSYavariPMozafariSFarzinniaSMohammadsharifiG.Platelet-rich plasma or extracorporeal shockwave therapy for plantar fasciitis. Int J Burns Trauma. 2021;11(1):1-8.
101.
PeerboomsJCLodderPden OudstenBLDoorgeestKSchullerHMGosensT.Positive effect of platelet-rich plasma on pain in plantar fasciitis: a double-blind multicenter randomized controlled trial. Am J Sports Med. 2019;47(13):3238-3246. doi:10.1177/0363546519877181
102.
KothariUShahSPancholiDChaudharyC.Efficacy and safety of platelet-rich plasma injection for chronic plantar fasciitis: a prospective study on functional restoration and pain relief. Cureus. 2024;16(1):e52414. doi:10.7759/cureus.52414
103.
ShettySHDhondAAroraMDeoreS.Platelet-rich plasma has better long-term results than corticosteroids or placebo for chronic plantar fasciitis: randomized control trial. J Foot Ankle Surg. 2019;58(1):42-46.
104.
Alessio-MazzolaMStambazziCUrsinoCTagliaficoATrentiniRFormicaM.Ultrasound-guided autologous platelet-rich plasma injections versus focal ultrasound-guided extracorporeal shockwave therapy for plantar fasciitis in athletes and nonathletes: a retrospective comparative study with minimum 2-year follow-up. J Foot Ankle Surg. 2023;62(3):417-421.
105.
TabriziADindarianSMohammadiS.The effect of corticosteroid local injection versus platelet-rich plasma for the treatment of plantar fasciitis in obese patients: a single-blind, randomized clinical trial. J Foot Ankle Surg. 2020;59(1):64-68.
106.
UğurlarMSönmezMMUğurlarÖYAdıyekeLYıldırımHErenOT.Effectiveness of four different treatment modalities in the treatment of chronic plantar fasciitis during a 36-month follow-up period: a randomized controlled trial. J Foot Ankle Surg. 2018;57(5):913-918.
107.
AdamsSBJrThorpeMAParksBGAghazarianGAllenESchonLC.Stem cell-bearing suture improves Achilles tendon healing in a rat model. Foot Ankle Int. 2014;35(3):293-299.
108.
UrdzikovaLMSedlacekRSuchyT, et al. Human multipotent mesenchymal stem cells improve healing after collagenase tendon injury in the rat. Biomed Eng Online. 2014;13:42.
109.
SteinBEStrohDASchonLC.Outcomes of acute Achilles tendon rupture repair with bone marrow aspirate concentrate augmentation. Int Orthop. 2015;39(5):901-905.
110.
KearneyRSJiCWarwickJ, et al. Effect of platelet-rich plasma injection vs sham injection on tendon dysfunction in patients with chronic midportion Achilles tendinopathy: a randomized clinical trial. JAMA. 2021;326(2):137-144. doi:10.1001/jama.2021.6986
111.
KroghTPEllingsenTChristensenRJensenPFredbergU.Ultrasound-guided injection therapy of Achilles tendinopathy with platelet-rich plasma or saline: a randomized, blinded, placebo-controlled trial. Am J Sports Med. 2016;44(8):1990-1997. doi:10.1177/0363546516647958
112.
BoesenAPHansenRBoesenMIMalliarasPLangbergH.Effect of high-volume injection, platelet-rich plasma, and sham treatment in chronic midportion Achilles tendinopathy: a randomized double-blinded prospective study. Am J Sports Med. 2017;45(9):2034-2043. doi:10.1177/0363546517702862
113.
LuJLiHZhangZXuRWangJJinH.Platelet-rich plasma in the pathologic processes of tendinopathy: a review of basic science studies. Front Bioeng Biotechnol. 2023;11:1187974. doi:10.3389/fbioe.2023.1187974
114.
JonassonTHZancanRde Oliveira AzevedoL, et al. Effects of low-level laser therapy and platelet concentrate on bone repair: histological, histomorphometric, immunohistochemical, and radiographic study. J Craniomaxillofac Surg. 2017;45(11):1846-1853.
115.
WhiteCBrahsADortonDWitfillK.Platelet-rich plasma: a comprehensive review of emerging applications in medical and aesthetic dermatology. J Clin Aesthet Dermatol. 2021;14(11):44-57.
116.
MirceaSLauraMSebastianHM, et al. Assessing the efficacy of laser therapy and autologous platelet-rich plasma (PRP) treatment for chronic wounds. J Pers Med. 2024;14(1):85. doi:10.3390/jpm14010085
117.
BarbosaDde SouzaRAde CarvalhoWR, et al. Low-level laser therapy combined with platelet-rich plasma on the healing calcaneal tendon: a histological study in a rat model. Lasers Med Sci. 2013;28(6):1489-1494. doi:10.1007/s10103-012-1241-x
118.
EncinasRPhillipsTHallSJacksonJB3rdGonzalezT.Outcomes and complications after bone marrow aspirate harvest from the calcaneus. Foot Ankle Orthop. 2023;8(3):24730114231194056. doi:10.1177/24730114231194056
119.
AllahabadiSJawandaHKhanZA, et al. Bone marrow aspirate concentrate harvest techniques for the sports medicine surgeon. Arthrosc Tech. 2024;13(2):102850. doi:10.1016/j.eats.2023.09.025
120.
HernigouPHommaYFlouzat LachanietteCH, et al. Benefits of small volume and small syringe for bone marrow aspirations of mesenchymal stem cells. Int Orthop. 2013;37(11):2279-2287.
