Lanostane-type Triterpenoids from Ganoderma lucidum and G. multipileum Fruiting Bodies

Abstract

Sixteen lanostane-type triterpeneoids were isolated from the fruiting bodies of wild Ganoderma lucidum and G. multipileum. The new structures 3S,24S,25,26-tetrahydroxy-5α-lanost-8-en-11-one (1) and ganodermanondiol 24,25-acetonide (10) were elucidated by means of spectroscopic data and Mosher's experiments. Lanosta-7,9(11)-dien-3β-ol (9) strongly inhibited α-glucosidase with the IC₅₀ values of 198.8 μM in compared with acarbose (IC₅₀ 712.4 μM).

Keywords

Ganoderma lucidum Ganoderma multipileum Ganodermataceae Lanostane α-Glucosidase

References

Xia

, Zhang

, Sun

, Zhao

, Wu

, Zhu

, Yang

, Shao

, Zhang

, Mao

, Zhang

, She

(2014) A comprehensive review of the structure elucidation and biological activity of triterpenoids from Ganoderma spp. Molecules, 19, 17478–17535.

Baby

, Johnson

A.J.

, Govindan

(2015) Secondary metabolites from Ganoderma. Phytochemistry, 114, 66–101.

Guan

, Min

, Xuan

, Xia

, Wang

, Hui

, Guo

(2006) two new lanostanoid triterpenes from the fruit body of Ganoderma lucidum-the major component of sunrecome. Natural Product Communications, 1, 177–181.

Jie

, Kuniyoshi

, Ryuichiro

(2006) Ganoderic acid TR, a new lanostanoid with 5'-reductase inhibitory activity from the fruiting body of Ganoderma lucidum. Natural Product Communications, 1, 345–350.

Cui

, Guan

, Feng

, Song

, Chao

, Cheng

, Wang

, Wu

, Yue

, Liu

, Guo

(2010) Cytotoxicity of 9,11-dehydroergosterol peroxide isolated from Ganoderma lucidum and its target-related proteins. Natural Product Communications, 5, 1183–1186.

Ghani

(2015) Re-exploring promising α-glucosidase inhibitors for potential development into oral anti-diabetic drugs: Finding needle in the haystack. European Journal of Medicinal Chemistry, 103, 133–162.

Nishitoba

, Oda

, Sato

, Sakamura

(1988) Novel triterpenoids from the Ganoderma lucidum. Agricultural and Biological Chemistry, 52, 367–372.

Min

B.S.

, Nakamura

, Miyashiro

, Bae

K.W.

, Hattori

(1998) Triterpenes from the spores of Ganoderma lucidum and their inhibitory activity against HIV-1 protease. Chemical & Pharmaceutical Bulletin, 46, 1607–1612.

Yodsaoue

, Sonprasit

, Karalai

, Ponglimanont

, Tewtrakul

, Chantrapromma

(2012) Diterpenoids and triterpenoids with potential anti-inflammatory activity from the leaves of Aglaia odorata. Phytochemistry, 76, 83–91.

10.

Fujita

, Arisawa

, Saga

, Hayashi

, Morita

(1986) Two new lanostanoids from Ganoderma lucidum. Journal of Natural Products, 49, 1122–1125.

11.

Hanh

T.T.H.

, Dang

N.H.

, Dat

N.T.

(2016) α-Amylase and α-glucosidase inhibitory saponins from Polyscias fruticosa leaves. Journal of Chemistry, 2016, 2082946.

Supplementary Material

Please find the following supplemental material available below.

For Open Access articles published under a Creative Commons License, all supplemental material carries the same license as the article it is associated with.

For non-Open Access articles published, all supplemental material carries a non-exclusive license, and permission requests for re-use of supplemental material or any part of supplemental material shall be sent directly to the copyright owner as specified in the copyright notice associated with the article.

0.00 MB

1.28 MB