A new gymnomitrane-type sesquiterpenoid, gymnomitrane-3α,5α,9β,15-tetrol(1), was isolated from the fruiting body of Ganoderma lucidum. Its structure was elucidated using spectroscopic methods. This compound significantly inhibited the growth of epidermal growth factor receptor-tyrosine kinase inhibitor EGFR-TKI-resistant human lung cancer A549 and human prostate cancer PC3 cell lines.
Wachtel-GalorS., BuswellJ.A., TomlinsonB., BenzieF.F. (2004) Lingzhi polyphorous fungus (Ganoderma lucidum). In Herbal and Traditional Medicine: Molecular Aspects of Health.PackerL., OngC.N., HalliwellB. (Ed). Marcel Dekker Inc., New York, 151–195.
2.
BabyS., JohnsonA.J., GovindanB. (2015) Secondary metabolites from Ganoderma.Phytochemistry, 114, 66–101.
3.
XiaQ., ZhangH., SunX., ZhaoH., WuL., ZhuD., YangG., ShaoY., ZhangX., MaoX., ZhangL., SheG. (2014) A comprehensive review of the structure elucidation and biological activity of triterpenoids from Ganoderma spp. Molecules, 19, 17478–17535.
YanY.M., AiJ., ZhouL.L., ChungA.C., LiR., NieJ., FangP., WangX.L., LuoJ., HuQ., HouF.F., ChengY.X. (2013) Lingzhiols, unprecedented rotary door-shaped meroterpenoids as potent and selective inhibitors of p-Smad3 from Ganoderma lucidum.Organic Letters, 15, 5488–5491.
6.
SeoH.W., HungT.M., NaM., JungH.J., KimJ.C., ChoiJ.S., KimJ.H., LeeH.K., LeeI., BaeK., HattoriM., MinB.S. (2009) Steroids and triterpenes from the fruit bodies of Ganoderma lucidum and their anti-complement activity. Archives of Pharmacal Research, 32, 1573–1579.
7.
AdamsM., ChristenM., PlitzkoI., ZimmermannS., BrunR., KaiserM., HamburgerM. (2010) Antiplasmodial lanostanes from the Ganoderma lucidum mushroom. Journal of Natural Products, 73, 897–900.
8.
ChenZ.M., ChenH.P., WangF., LiZ.H., FengT., LiuJ.K. (2015) New triquinane and gymnomitrane sesquiterpenes from fermentation of the basidiomycete Antrodiella albocinnamomea.Fitoterapia, 102, 61–66.
9.
LiuJ.Q., WangC.F., LiY., LuoH.R., QiuM.H. (2012) Isolation and bioactivity evaluation of terpenoids from the medicinal fungus Ganoderma sinense.Planta Medica, 78, 368–376.
10.
WarmersU., KönigW.A. (2000) Biosynthesis of the gymnomitrane-type sesquiterpenes in liverworts. Phytochemistry, 53, 645–650.
11.
WuC.L., KaoT.L. (2002) A new gymnomitrane-type sesquiterpenoid from the liverwort Cylindrocolea recurvifolia.Journal of Asian Natural Products Research, 4, 281–285.
12.
RolfoC., GiovannettiE., HongD.S., BivonaT., RaezL.E., BronteG., BuffoniL., ReguartN., SantosE.S., GermonpreP., TaronM., PassigliaF., Van MeerbeeckJ.P., RussoA., PeetersM., Gil-BazoI., PauwelsP., RosellR. (2014) Novel therapeutic strategies for patients with NSCLC that do not respond to treatment with EGFR inhibitors. Cancer Treatment Reviews, 40, 990–1004.
