Chemical analysis of the ethanolic extract of the Australian rainforest plant Elaeocarpus eumundi yielded a new phenolic monosaccharide (1) and the known dihydropieceid (2). The structures of both compounds were elucidated based on the spectroscopic methods including UV, HR-ESIMS and 1D, 2D NMR data. Compounds 1 and 2 exhibited good anti-inflammatory activity in LPS and IFN-γ activated RAW 264.7 macrophage cells.
EncinasJ.M., ManganasL., EnikolopovG. (2005) Nitric oxide and multiple sclerosis. Current Neurology & Neuroscience Reports, 5, 232–238.
3.
PitoccoD., ZaccardiF., Di StasioE., RomitelliF., SantiniS.A., ZuppiC., GhirlandaG. (2010) Oxidative Stress, Nitric Oxide, and Diabetes. The Review of Diabetic Studies, 7, 15–25.
4.
DawsonV.L., DawsonT.M. (1996) Nitric oxide neurotoxicity. Journal of Chemical Neuroanatomy, 10, 179–190.
5.
ClancyR.M., AminA.R., AbramsonS.B. (1998) The role of nitric oxide in inflammation and immunity. Arthritis Rheumatism, 41, 1141–1151.
6.
LeeH., KimN., JangM., SonH., KimK., SohnD., LeeS., RyuJ. (1999) A sesquiterpene, dehydrocostus lactone, inhibits the expression of inducible nitric oxide synthase and TNF-alpha in LPS-activated macrophages. Planta Medica, 65, 104–108.
7.
SartorL., PezzatoE., Dell'AicaI., CaniatoR., BigginS., GarbisaS. (2002) Inhibition of matrix-proteases by polyphenols: chemical insights for anti-inflammatory and anti-invasion drug design. Biochemical Pharmacology, 64, 229–237.
8.
ScuroL.S., SimioniP.U., GrabrielD.L., SavianiE.E., ModoloL V., TamashiroWmsc, SalgadoI. (2004) Suppression of nitric oxide production in mouse macrophages by soybean flavonoids accumulated in response to nitroprusside and fungal elicitation. BMC Biochemistry, 5, 5.
9.
HegdeV.R., PuÃH, PatelM., BlackT., SorianoA., ZhaoW., GulloV.P., ChanT. (2004) Two new bacterial DNA primase inhibitors from the plant Polygonum cuspidatum. Bioorganic & Medicinal Chemistry Letters, 14, 2275–2277.
10.
LeeJ.P., MinB.S., AnR.B., NaM.K., LeeS.M., LeeH.K., KimJ.G., BaeK.H., KangS.S. (2003) Stilbenes from the roots of Pleuropterus ciliinervis and their antioxidant activities. Phytochemistry, 64, 759–763.
11.
FengW.S., CaoX.W., KuangH.X., ZhengX.K. (2005) A new stilbene glycoside from Dryopteris sublaeta. Yaoxue Xuebao, 40, 1131–1134.
12.
HathwayD.E. (1962) The use of hydroxystilbene compounds as taxonomic tracers in the genus Eucalyptus. Biochemical Journal, 83, 80–84.
13.
RanX.K., WangX.T., LiuP.P., ChiY.X., WangB.J., DouD.Q., KangT.G., XiongW. (2013) Cytotoxic constituents from the leaves of Broussonetia papyrifera. Chinese Journal of Natural Medicine, 11, 269–273.
14.
ChiX., XingY., XiaoY., DongQ., HuF. (2014) Separation and purification of three stilbenes from the radix of Polygonum cillinerve (Nakai) Ohwl by macroporous resin column chromatography combined with high-speed counter-current chromatography. Química Nova, 37, 1465–1468.