Aglaia odorata Lour. is a traditional herbal medicine belonging to the Meliaceae family. The aim of this study was to identify useful compounds for human health from A odorata. Our phytochemical investigation resulted in the isolation of four constituents hesperetin-7,3’-O-dimethylether, 5α-dammar-20-ene-3β,24,25-triol, odorine, and odorinol. All compounds suppressed LPS-induced TNF-α expression in rat immortalized microglia HAPI cells; especially, hesperetin-7,3’-O-dimethylether showed most potent inhibitory effect. In addition, molecular docking analysis demonstrated that hesperetin-7,3’-O-dimethylether could be accommodated within hot spots of TNF-α dimeric protein.
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