Cereals are suggested to be the most important sources of lignan in the diets of western populations. Recent epidemiological studies show that European subpopulations in which the major source of lignans are cereals, display lower disease frequency regarding metabolic and cardiovascular diseases. The biological mechanisms of lignan are several. Beyond their antioxidant and anti-inflammatory actions at nutritional doses some lignans regulate the activity of specific nuclear receptors (NRs), such as the estrogen receptors (ERs), and also NRs that are central switches in glucose and fatty acid metabolism such as PPARα, PPARγ and LXRs, highlighting them as selective nuclear receptor modulators (SNRMs). These include enterodiol (END) and enterolactone (ENL), the metabolites produced by the gut microbiota from food lignans. The available knowledge suggests that given some additional research it should be possible to make ‘function' claims for a regular intake of lignans-rich foods related to maintaining a healthy metabolism.
NooyensAC, MilderIE, van GelderBM, Bueno-de-MesquitaHB, van BoxtelMP, VerschurenWM. (2015) Diet and cognitive decline at middle age: the role of antioxidants. British Journal of Nutrition, 113, 1410–1417.
2.
KhalesiS, IrwinC, SchubertM. (2015) Flaxseed consumption may reduce blood pressure: a systematic review and meta-analysis of controlled trials. Journal of Nutrition, 145, 758–765
3.
Tresserra-RimbauA, RimmEB, Medina-RemónA, Martínez-GonzálezMA, de la TorreR, CorellaD, Salas-SalvadóJ, Gómez-GraciaE, LapetraJ, ArósF, FiolM, RosE, Serra-MajemL, PintóX, SaezGT, BasoraJ, SorlíJV, MartínezJA, VinyolesE, Ruiz-GutiérrezV, EstruchR, Lamuela-RaventósRM. (2014) Investigators PS. Inverse association between habitual polyphenol intake and incidence of cardiovascular events in the PREDIMED study. Nutrition Metabolism and Cardiovascular Disease, 24, 639–647.
4.
SchogorAL, HuwsSA, SantosGT, ScollanND, HauckBD, WintersAL, KimEJ, PetitHV. (2014) Ruminal Prevotella spp. may play an important role in the conversion of plant lignans into human health beneficial antioxidants. PLoS One9, e87949.
5.
SunQ, WedickNM, PanA, TownsendMK, CassidyA, FrankeAA, RimmEB, HuFB, van DamRM. (2014) Gut microbiota metabolites of dietary lignans and risk of type 2 diabetes: a prospective investigation in two cohorts of U.S. women. Diabetes Care, 37, 1287–1295.
6.
SaggarJK, ChenJ, CoreyP, ThompsonLU. (2010) Dietary flaxseed lignan or oil combined with tamoxifen treatment affects MCF-7 tumor growth through estrogen receptor- and growth factor-signaling pathways. Molecular Nutrition and Food Research, 54, 415–425.
7.
DamdimopoulouP, NurmiT, SalminenA, DamdimopoulosAE, KotkaM, van der SaagP, StraussL, PoutanenM, PongratzI, MäkeläS. (2011) A single dose of enterolactone activates estrogen signaling and regulates expression of circadian clock genes in mice. Journal of Nutrition, 141, 1583–1589.
8.
Zamora-RosR, AgudoA, Luján-BarrosoL, RomieuI, FerrariP, KnazeV, Bueno-de-MesquitaHB, LeendersM, TravisRC, NavarroC, Sánchez-CantalejoE, SlimaniN, ScalbertA, FedirkoV, HjartåkerA, EngesetD, SkeieG, BoeingH, FörsterJ, LiK, TeucherB, AgnoliC, TuminoR, MattielloA, SaievaC, JohanssonI, StenlingR, RedondoML, WallströmP, EricsonU, KhawKT, MulliganAA, TrichopoulouA, DilisV, KatsoulisM, PeetersPH, IgaliL, TjønnelandA, HalkjærJ, TouillaudM, PerquierF, FagherazziG, AmianoP, ArdanazE, BredsdorffL, OvervadK, RicceriF, RiboliE, GonzálezCA. (2012) Dietary flavonoid and lignan intake and gastric adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. American Journal of Clinical Nutrition, 96, 1398–1408.
9.
Zamora-RosR, ForouhiNG, SharpSJ, GonzálezCA, BuijsseB, GuevaraM, van der SchouwYT, AmianoP, BoeingH, BredsdorffL, Clavel-ChapelonF, FagherazziG, FeskensEJ, FranksPW, GrioniS, KatzkeV, KeyTJ, KhawKT, KühnT, MasalaG, MattielloA, Molina-MontesE, NilssonPM, OvervadK, PerquierF, QuirósJR, RomieuI, SacerdoteC, ScalbertA, SchulzeM, SlimaniN, SpijkermanAM, TjonnelandA, TormoMJ, TuminoR, van derA DL, LangenbergC, RiboliE, WarehamNJ. (2013) The association between dietary flavonoid and lignan intakes and incident type 2 diabetes in European populations: the EPIC-InterAct study. Diabetes Care, 36, 3961–3970.
10.
Zamora-RosR, JiménezC, CleriesR, AgudoA, SánchezMJ, Sánchez-CantalejoE, Molina-MontesE, NavarroC, ChirlaqueMD, María HuertaJ, AmianoP, RedondoML, BarricarteA, GonzálezCA. (2013) Dietary flavonoid and lignan intake and mortality in a Spanish cohort. Epidemiology, 24, 726–733.
11.
FrankenfeldCL. (2014) Cardiometabolic risk factors are associated with high urinary enterolactone concentration, independent of urinary enterodiol concentration and dietary fiber intake in adults. Journal of Nutrition, 144, 1445–1453.
12.
SwannR, PerkinsKA, VelentzisLS, CiriaC, DuttonSJ, MulliganAA, WoodsideJV, CantwellMM, LeathemAJ, RobertsonCE, DwekMV. (2013) The DietCompLyf study: a prospective cohort study of breast cancer survival and phytoestrogen consumption. Maturitas, 75, 232–240.
13.
TetensI, TurriniA, TapanainenH, ChristensenT, LampeJW, FagtS, HåkanssonN, LundquistA, HallundJ, ValstaLM, groupPWw. (2013) Dietary intake and main sources of plant lignans in five European countries. Food and Nutrition Research, 57.
14.
SmedsAI, EklundPC, SjöholmRE, WillförSM, NishibeS, DeyamaT, HolmbomBR. (2007) Quantification of a broad spectrum of lignans in cereals, oilseeds, and nuts. Journal of Agricultural and Food Chemistry, 55, 1337–1346.
15.
SmedsAI, JauhiainenL, TuomolaE, Peltonen-SainioP. (2009) Characterization of variation in the lignan content and composition of winter rye, spring wheat, and spring oat. Journal of Agricultural and Food Chemistry, 57, 5837–5842.
16.
FreiseC, Trowitzsch-KienastW, ErbenU, SeehoferD, KimKY, ZeitzM, RuehlM, SomasundaramR. (2013) (+)-Episesamin inhibits adipogenesis and exerts anti-inflammatory effects in 3T3-L1 (pre)adipocytes by sustained Wnt signaling, down-regulation of PPARγ and induction of iNOS. Journal of Nutritional Biochemestry, 24, 550–555.
PenttinenP, JaehrlingJ, DamdimopoulosAE, InzunzaJ, LemmenJG, van der SaagP, PetterssonK, GauglitzG, MäkeläS, PongratzI. (2007) Diet-derived polyphenol metabolite enterolactone is a tissue-specific estrogen receptor activator. Endocrinology, 148, 4875–4886.
19.
CosentinoM, MarinoF, FerrariM, RasiniE, BombelliR, LuiniA, LegnaroM, Delle CanneMG, LuzzaniM, CremaF, ParacchiniS, LecchiniS. (2007) Estrogenic activity of 7-hydroxymatairesinol potassium acetate (HMR/lignan) from Norway spruce (Picea abies) knots and of its active metabolite enterolactone in MCF-7 cells. Pharmacological Research, 56, 140–147.
20.
PeñalvoJL, López-RomeroP. (2012) Urinary enterolignan concentrations are positively associated with serum HDL cholesterol and negatively associated with serum triglycerides in U.S. adults. Journal of Nutrition, 142, 751–756.
21.
BoucherBA, CotterchioM, CurcaIA, KreigerN, HarrisSA, KirshVA, GoodwinPJ. (2012) Intake of phytoestrogen foods and supplements among women recently diagnosed with breast cancer in Ontario, Canada. Nutrition and Cancer, 64, 695–703.
22.
CunhaWR, AndradeML, Cassio SalaVeneziani R, AmbrosioRS, BastosJK. (2012) Lignans: Chemical and biological properties. In Phytochemicals - A global perspective of their role in nutrition and health. VenketeshwerRao (Ed), InTech, ISBN 978–953–51-0296-0
23.
SuzukiS, YamamuraM, HattoriT, NakatsuboT, UmezawaT. (2007) The subunit composition of hinokiresinol synthase controls geometrical selectivity in norlignan formation. Proceedings of the National Academy of Sciences USA, 104, 21008–21013.
24.
YousefzadiM, SharifiM, ChashmiNA, BehmaneshM, GhasempourA. (2010) Optimization of podophyllotoxin extraction method from Linum album cell cultures. Pharmaceutical Biology, 48, 1421–1425.
25.
ClavelT, HendersonG, AlpertCA, PhilippeC, Rigottier-GoisL, DoréJ, BlautM. (2005) Intestinal bacterial communities that produce active estrogen-like compounds enterodiol and enterolactone in humans. Applied Environemental Microbiology, 71, 6077–6085.
26.
YouY. (2005) Podophyllotoxin derivatives: current synthetic approaches for new anticancer agents. Current Pharmaceutical Design, 11, 1695–1717.
27.
NurmiT, MursuJ, PeñalvoJL, PoulsenHE, VoutilainenS. (2010) Dietary intake and urinary excretion of lignans in Finnish men. British Journal of Nutrition, 103, 677–685.
28.
MervishNA, GardinerEW, GalvezMP, KushiLH, WindhamGC, BiroFM, PinneySM, RybakME, TeitelbaumSL, WolffMS. (2013) BCERP. Dietary flavonol intake is associated with age of puberty in a longitudinal cohort of girls. Nutrition Research, 33, 534–542.
29.
WuH, PanA, YuZ, QiQ, LuL, ZhangG, YuD, ZongG, ZhouY, ChenX, TangL, FengY, ZhouH, LiH, Demark-WahnefriedW, HuFB, LinX. (2010) Lifestyle counseling and supplementation with flaxseed or walnuts influence the management of metabolic syndrome. Journal of Nutrition, 140, 1937–1942.
30.
SmedsAI, WillförSM, PietarinenSP, Peltonen-SainioP, ReunanenMH. (2007) Occurrence of “mammalian” lignans in plant and water sources. Planta, 226, 639–646.
31.
BrounsF, HemeryY, PriceR, AnsonNM. (2012) Wheat aleurone: separation, composition, health aspects, and potential food use. Critical Review in Food Science and Nutrition, 52, 553–568.
32.
van der KampJW, PoutanenK, SealCJ, RichardsonDP. (2014) The HEALTHGRAIN definition of ‘whole grain’. Food and Nutrition Research, 58, 22100.
33.
CukeljN, JakasaI, SarajlijaH, NovotniD, CurićD. (2011) Identification and quantification of lignans in wheat bran by gas chromatography-electron capture detection. Talanta, 84, 127–132.
34.
SmedsAI, SaarinenNM, EklundPC, SjöholmRE, MäkeläSI. (2005) New lignan metabolites in rat urine. Journal of Chromatography B Analytical Technology in Biomedical and Life Science, 816, 87–97.
35.
DinelliG, Segura-CarreteroA, Di SilvestroR, MarottiI, Arráez-RománD, BenedettelliS, GhiselliL, Fernadez-GutierrezA. (2011) Profiles of phenolic compounds in modern and old common wheat varieties determined by liquid chromatography coupled with time-of-flight mass spectrometry. Journal of Chromatography A, 1218, 7670–7681.
36.
MazurW. (1998) Phytoestrogen content in foods. Baillieres Clinical Endocrinology and Metabolism, 12, 729–742.
37.
Bondia -PonsI, BarriT, HanhinevaK, JuntunenK, DragstedLO, MykkänenH, PoutanenK. (2013) UPLC-QTOF/MS metabolic profiling unveils urinary changes in humans after a whole grain rye versus refined wheat bread intervention. Molecular Nutrition and Food Research, 57, 412–422.
38.
NiemiP, TamminenT, SmedsA, ViljanenK, Ohra-ahoT, Holopainen-MantilaU, FauldsCB, PoutanenK, BuchertJ. (2012) Characterization of lipids and lignans in brewer's spent grain and its enzymatically extracted fraction. Journal of Agricultural and Food Chemistry, 60, 9910–9917.
39.
AnsonNM, SelinheimoE, HavenaarR, AuraAM, MattilaI, LehtinenP, BastA, PoutanenK, HaenenGR. (2009) Bioprocessing of wheat bran improves in vitro bioaccessibility and colonic metabolism of phenolic compounds. Journal of Agricultural and Food Chemistry, 57, 6148–6155.
40.
AnsonNM, HavenaarR, VaesW, CoulierL, VenemaK, SelinheimoE, BastA, HaenenGR. (2011) Effect of bioprocessing of wheat bran in wholemeal wheat breads on the colonic SCFA production in vitro and postprandial plasma concentrations in men. Food Chemistry, 128, 404–409.
41.
WangY, YuQ, ChenY, CaoF. (2013) Pathophysiology and therapeutics of cardiovascular disease in metabolic syndrome. Current Pharmaceutical Design, 19, 4799–4805.
42.
EhrhardtMJ, MulrooneyDA. (2015) Metabolic syndrome in adult survivors of childhood cancer: the intersection of oncology, endocrinology, and cardiology. Lancet Diabetes and Endocrinolology, 3, 494–496.
43.
TamayoT, RosenbauerJ, WildSH, SpijkermanAM, BaanC, ForouhiNG, HerderC, RathmannW. (2014) Diabetes in Europe: an update. Diabetes Research and Clinical Practice, 103, 206–217.
44.
2003 RoaJWFEC (2003) Diet, nutrition and the prevention of chronic disease. In Serie WTR (Ed) Geneva.
45.
Communities. GPoCotE (2005) Promoting healthy diets and physical activity: a European dimension for the prevention of the obesity and chronic disease. In Protection DGHaC, (Ed) Brussels.
46.
Level. WpopcaC. (2007) A strategy of Europe on nutrition, overweight and obesity related health issues. Brussels.
47.
StrujaT, RichardA, LinseisenJ, EichholzerM, RohrmannS. (2014) The association between urinary phytoestrogen excretion and components of the metabolic syndrome in NHANES. European Journal of Nutrition, 53, 1371–1381.
48.
Zamora-RosR, KnazeV, Luján-BarrosoL, KuhnleGG, MulliganAA, TouillaudM, SlimaniN, RomieuI, PowellN, TuminoR, PeetersPH, de MagistrisMS, RicceriF, SonestedtE, DrakeI, HjartåkerA, SkieG, MouwT, WarkPA, RomagueraD, Bueno-de-MesquitaHB, RosM, MolinaE, SieriS, QuirósJR, HuertaJM, TjønnelandA, HalkjærJ, MasalaG, TeucherB, KaasR, TravisRC, DilisV, BenetouV, TrichopoulouA, AmianoP, ArdanazE, BoeingH, FörsterJ, Clavel-ChapelonF, FagherazziG, PerquierF, JohanssonG, JohanssonI, CassidyA, OvervadK, GonzálezCA. (2012) Dietary intakes and food sources of phytoestrogens in the European Prospective Investigation into Cancer and Nutrition (EPIC) 24-hour dietary recall cohort. European Journal of Clinical Nutrition, 66, 932–941.
49.
Zamora-RosR, FedirkoV, TrichopoulouA, GonzálezCA, BamiaC, TrepoE, NöthlingsU, Duarte-SallesT, SerafiniM, BredsdorffL, OvervadK, TjønnelandA, HalkjaerJ, FagherazziG, PerquierF, Boutron-RuaultMC, KatzkeV, LukanovaA, FloegelA, BoeingH, LagiouP, TrichopoulosD, SaievaC, AgnoliC, MattielloA, TuminoR, SacerdoteC, Bueno-de-MesquitaHB, PeetersPH, WeiderpassE, EngesetD, SkeieG, ArgüellesMV, Molina-MontesE, DorronsoroM, TormoMJ, ArdanazE, EricsonU, SonestedtE, SundM, LandbergR, KhawKT, WarehamNJ, CroweFL, RiboliE, JenabM. (2013) Dietary flavonoid, lignan and antioxidant capacity and risk of hepatocellular carcinoma in the European prospective investigation into cancer and nutrition study. International Journal of Cancer, 133, 2429–2443.
50.
Zamora-RosR, FerrariP, GonzálezCA, TjønnelandA, OlsenA, BredsdorffL, OvervadK, TouillaudM, PerquierF, FagherazziG, LukanovaA, TikkK, AleksandrovaK, BoeingH, TrichopoulouA, TrichopoulosD, DilisV, MasalaG, SieriS, MattielloA, TuminoR, RicceriF, Bueno-de-MesquitaHB, PeetersPH, WeiderpassE, SkeieG, EngesetD, MenéndezV, TravierN, Molina-MontesE, AmianoP, ChirlaqueMD, BarricarteA, WallströmP, SonestedtE, SundM, LandbergR, KhawKT, WarehamNJ, TravisRC, ScalbertA, WardHA, RiboliE, RomieuI. (2013) Dietary flavonoid and lignan intake and breast cancer risk according to menopause and hormone receptor status in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study. Breast Cancer Research and Treatment, 139, 163–176.
51.
Zamora-RosR, SacerdoteC, RicceriF, WeiderpassE, RoswallN, BucklandG, St-JulesDE, OvervadK, KyrøC, FagherazziG, KvaskoffM, SeveriG, Chang-ClaudeJ, KaaksR, NöthlingsU, TrichopoulouA, NaskaA, TrichopoulosD, PalliD, GrioniS, MattielloA, TuminoR, GramIT, EngesetD, HuertaJM, Molina-MontesE, ArgüellesM, AmianoP, ArdanazE, EricsonU, LindkvistB, NilssonLM, KiemeneyLA, RosM, Bueno-de-MesquitaHB, PeetersPH, KhawKT, WarehamNJ, KnazeV, RomieuI, ScalbertA, BrennanP, WarkP, VineisP, RiboliE, GonzálezCA. (2014) Flavonoid and lignan intake in relation to bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. British Journal of Cancer, 111, 1870–1880.
52.
WardHA, KuhnleGG. (2010) Phytoestrogen consumption and association with breast, prostate and colorectal cancer in EPIC Norfolk. Archives of Biochemistry and Biophysics, 501, 170–175.
53.
WardHA, KuhnleGG, MulliganAA, LentjesMA, LubenRN, KhawKT. (2010) Breast, colorectal, and prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition-Norfolk in relation to phytoestrogen intake derived from an improved database. American Journal of Clinical Nutrition, 91, 440–448.
54.
MulliganAA, KuhnleGG, LentjesMA, van ScheltingaV, PowellNA, McTaggartA, BhanianiA, KhawKT. (2013) Intakes and sources of isoflavones, lignans, enterolignans, coumestrol and soya-containing foods in the Norfolk arm of the European Prospective Investigation into Cancer and Nutrition (EPIC-Norfolk), from 7 d food diaries, using a newly updated database. Public Health Nutrition, 16, 1454–1462.
55.
XuC, LiuQ, ZhangQ, JiangZY, GuA. (2015) Urinary enterolactone associated with liver enzyme levels in US adults: National Health and Nutrition Examination Survey (NHANES). British Journal of Nutrition, 114, 91–97.
NarasimhuluCA, SelvarajanK, LitvinovD, ParthasarathyS. (2015) Anti-atherosclerotic and anti-inflammatory actions of sesame oil. Journal of Medicinal Food, 18, 11–20.
58.
ZhangW, WangX, LiuY, TianH, FlickingerB, EmpieMW, SunSZ. (2008) Dietary flaxseed lignan extract lowers plasma cholesterol and glucose concentrations in hypercholesterolaemic subjects. British Journal of Nutrition, 99, 1301–1309.
59.
HongL, YiW, LiangliangC, JunchengH, QinW, XiaoxiangZ. (2013) Hypoglycaemic and hypolipidaemic activities of sesamin from sesame meal and its ability to ameliorate insulin resistance in KK-Ay mice. Journal of the Science of Food and Agriculture, 93, 1833–1838.
60.
KimMH, ChoiYY, HanJM, LeeHS, HongSB, LeeSG, YangWM. (2014) Ameliorative effects of Schizandra chinensis on osteoporosis via activation of estrogen receptor (ER)-α/-β. Food and Function, 5, 1594–1601.
61.
WanY, LiH, FuG, ChenX, ChenF, XieM. (2015) The relationship of antioxidant components and antioxidant activity of sesame seed oil. Journal of the Science of Food and Agriculture, 95, 2571–2578.
62.
SooryM. (2012) Nutritional antioxidants and their applications in cardiometabolic diseases. Infectious Disorders - Drug Targets, 12, 388–401.
63.
ZhangX, XuX, XuT, QinS. (2014) β-Ecdysterone suppresses interleukin-1β-induced apoptosis and inflammation in rat chondrocytes via inhibition of NF-κB signaling pathway. Drug Development Research, 75, 195–201.
64.
SpiliotiE, HolmbomB, PapavassiliouAG, MoutsatsouP. (2014) Lignans 7-hydroxymatairesinol and 7-hydroxymatairesinol 2 exhibit anti-inflammatory activity in human aortic endothelial cells. Molecular Nutrition and Food Research, 58, 749–759.
65.
FreiseC, QuerfeldU. (2015)The lignan (+)-episesamin interferes with TNF-α-induced activation of VSMC via diminished activation of NF-κB, ERK1/2 and AKT and decreased activity of gelatinases. Acta Physiologica (Oxford), 213, 642–652.
66.
DikshitA, Gomes FilhoMA, EilatiE, McGeeS, SmallC, GaoC, KlugT, HalesDB. (2015) Flaxseed reduces the pro-carcinogenic microenvironment in the ovaries of normal hens by altering the PG and oestrogen pathways in a dose-dependent manner. British Journal of Nutrition, 113, 1384–1395.
67.
FukumitsuS, AidaK, UenoN, OzawaS, TakahashiY, KoboriM. (2008) Flaxseed lignan attenuates high-fat diet-induced fat accumulation and induces adiponectin expression in mice. British Journal of Nutrition, 100, 669–676.
68.
YangS, YangD, HuK, ZhouH, GuoY, DuG, LuY. (2015) Certification of a new certified reference material of honokiol. Analytical Bioanalytical Chemistry, 407, 5849–5855.
JungCG, HorikeH, ChaBY, UhmKO, YamauchiR, YamaguchiT, HosonoT, IidaK, WooJT, MichikawaM. (2010) Honokiol increases ABCA1 expression level by activating retinoid X receptor beta. Biological and Pharmaceutical Bulletin, 33, 1105–1111.
71.
JeonJS, OhSJ, LeeJY, RyuCS, KimYM, LeeBH, KimSK. (2015) Metabolic characterization of meso-dihydroguaiaretic acid in liver microsomes and in mice. Food Chemical and Toxicology, 76, 94–102.
72.
PeriasamyS, HsuDZ, ChangPC, LiuMY. (2014) Sesame oil attenuates nutritional fibrosing steatohepatitis by modulating matrix metalloproteinases-2, 9 and PPAR-γ. The Journal of Nutritional Biochemestry, 25, 337–344.
73.
HsiehCC, KuoCH, KuoHF, ChenYS, WangSL, ChaoD, LeeMS, HungCH. (2014) Sesamin suppresses macrophage-derived chemokine expression in human monocytes via epigenetic regulation. Food and Function, 5, 2494–2500.
74.
OgungbeIV, CrouchRA, DemeritteT. (2014) (-) Arctigenin and (+) pinoresinol are antagonists of the human thyroid hormone receptor β. Journal of Chemical Information and Modeling, 54, 3051–3055.
75.
JiangD, MaS, JingF, XuC, YanF, WangA, ZhaoJ. (2015) Thyroid-stimulating hormone inhibits adipose triglyceride lipase in 3T3-L1 adipocytes through the PKA pathway. PLoS One10, e0116439.
76.
JacobsMN, NolanGT, HoodSR. (2005) Lignans, bacteriocides and organochlorine compounds activate the human pregnane X receptor (PXR). Toxicology and Applied Pharmacology, 209, 123–133.
77.
BiasiottoG, PenzaM, ZanellaI, CadeiM, CaimiL, RossiniC, SmedsAI, DiLorenzo D. (2014) Oilseeds ameliorate metabolic parameters in male mice, while contained lignans inhibit 3T3-L1 adipocyte differentiation in vitro. European Journal of Nutrition, 53, 1685–1697.
78.
JenneweinC, KuhnAM, SchmidtMV, Meilladec-JulligV, von KnethenA, GonzalezFJ, BrüneB. (2008) Sumoylation of peroxisome proliferator-activated receptor gamma by apoptotic cells prevents lipopolysaccharide-induced NCoR removal from kappaB binding sites mediating transrepression of proinflammatory cytokines. Journal of Immunology, 181, 5646–5652.
79.
LinCH, ShenML, ZhouN, LeeCC, KaoST, WuDC. (2014) Protective effects of the polyphenol sesamin on allergen-induced T(H)2 responses and airway inflammation in mice. PLoS One, 9, e96091.
80.
RossiM, AmarettiA, LeonardiA, RaimondiS, SimoneM, QuartieriA. (2013) Potential impact of probiotic consumption on the bioactivity of dietary phytochemicals. Journal of Agricultural and Food Chemestry, 61, 9551–9558.
81.
ZhuL, GeG, ZhangH, LiuH, HeG, LiangS, ZhangY, FangZ, DongP, FinelM, YangL. (2012) Characterization of hepatic and intestinal glucuronidation of magnolol: application of the relative activity factor approach to decipher the contributions of multiple UDP-glucuronosyltransferase isoforms. Drug Metabolism and Disposition, 40, 529–538.
82.
JinJS, HattoriM. (2010) Human intestinal bacterium, strain END-2 is responsible for demethylation as well as lactonization during plant lignan metabolism. Biological and Pharmaceutical Bulletin, 33, 1443–1447.
83.
JanKC, ChangYW, HwangLS, HoCT. (2012) Tissue distribution and cytochrome P450 inhibition of sesaminol and its tetrahydrofuranoid metabolites. Journal of Agricultural and Food Chemestry, 60, 8616–8623.
84.
DavisCD, MilnerJA. (2009) Gastrointestinal microflora, food components and colon cancer prevention. Journal of Nutritional Biochemistry, 20, 743–752.
85.
MukkerJK, SinghRS, MuirAD, KrolES, AlcornJ. (2015) Comparative pharmacokinetics of purified flaxseed and associated mammalian lignans in male Wistar rats. British Journal of Nutrition, 113, 749–757.
86.
HullarMA, LancasterSM, LiF, TsengE, BeerK, AtkinsonC, WähäläK, CopelandWK, RandolphTW, NewtonKM, LampeJW. (2015) Enterolignan-producing phenotypes are associated with increased gut microbial diversity and altered composition in premenopausal women in the United States. Cancer Epidemiological, Biomarkers and Prevention, 24, 546–554.
87.
WotingA, ClavelT, LohG, BlautM. (2010) Bacterial transformation of dietary lignans in gnotobiotic rats. FEMS Microbiology Ecology, 72, 507–514.
88.
EichholzerM, RichardA, NicastroHL, PlatzEA, LinseisenJ, RohrmannS. (2014) Urinary lignans and inflammatory markers in the US National Health and Nutrition Examination Survey (NHANES) 1999–2004 and 2005–2008. Cancer Causes and Control, 25, 395–403.
89.
ZhangJ, ChenJ, LiangZ, ZhaoC. (2014) New lignans and their biological activities. Chemistry and Biodiversity, 11, 1–54.
90.
GilA, OrtegaRM, MaldonadoJ. (2011) Wholegrain cereals and bread: a duet of the Mediterranean diet for the prevention of chronic diseases. Public Health Nutrition, 14, 2316–2322.
