Two New Phenanthrene Glucosides from Cremastra appendiculata and their Cytotoxic Activities

Abstract

Two new phenanthrene glucosides, named 2′-hydroxy-4,4′,7′-trimethoxy-1,1′-biphenanthrene-2,7-di-O-β-D-glucoside (1) and 1-(4-hydroxybenzyl)-4-methoxy-2,7-dihydroxy-phenanthrene-8-O-β-D-glucoside (2), together with three known compounds were isolated from the tubers of Cremastra appendiculata (D. Don) Makino. Their structures were elucidated on the basis of spectral data. Compounds 1–4 showed moderate cytotoxic activity and compound 5 showed weak cytotoxic activity against the two cell lines tested. This is the first reported occurrence of an unusual biphenanthrene glucoside in this plant.

Keywords

Cremastra appendiculata Biphenanthrene glucoside Cytotoxic activity

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