In this study, we partially purified the ethyl acetate soluble fraction of the ethanol extract of the root of Allum hookeri. We identified seven compounds, benzoic acid, tetradecanoic acid, hexadecanoic acid, ferulic acid, cinnamic acid, octadecanoic acid and hexanedioic acid, that have antimicrobial activity using GC-MS, and evaluated the antimicrobial susceptibility and MIC (minimum inhibitory concentration) against multidrug-resistant bacteria.
KimCH, LeeMA, KimTW, JangJY, KimHJ. (2012) Anti-inflammatory effect of Allium hookeri root methanol extract in LPS-induced RAW264.7 cells. Journal of Korea Society of Food Science and Nutrition, 41, 1645–4658.
2.
LiR, WangYF, SunQ, HuHB. (2014) Chemical composition and antimicrobial activity of the essential oil from Allium hookeri consumed in Xishuangbanna, southwest China. Natural Product Communications, 9, 863–864.
3.
GuzmanJD. (2014) Natural cinnamic acids, synthetic derivatives and hybrids with antimicrobial activity. Molecules, 19, 19292–19349.
4.
ChoiJS, ParkNH, HwangSY, SohnJH, KwakI, ChoKK, ChoiIS. (2013) The antibacterial activity of various saturated and unsaturated fatty acids against several oral pathogens. Journal of Environmental Biololgy, 34, 673–676.
5.
AzizNH, FaragSE, MousaLA, Abo-ZaidMA. (1998) Comparative antibacterial and antifungal effects of some phenolic compounds. Microbios, 93, 43–54.
6.
HuangCB, AlimovaY, MyersTM, EbersoleJL. (2011) Short- and medium-chain fatty acids exhibit antimicrobial activity for oral microorganisms. Archives of Oral Biology, 56, 650–654.
7.
PuZH, ZhangYQ, YinZQ, XuJ, JiaRY, LuY, YangF. (2010) Antibacterial activity of 9-octadecanoic acid-hexadecanoic acid-tetrahydrofuran-3,4-diyl ester from neem oil. Agricultural Sciences in China, 9, 1236–1240.
8.
ChoiWH, JiangM. (2014) Evaluation of antibacterial activity of hexanedioic acid isolated from Hermetia illucens larvae. Journal of Applied Biomedicine, 12, 179–189.
9.
LiebowitzLD. (2009) MRSA burden and interventions. International Journal of Antimicrobial Agents, 34Suppl 3, S11–13.
MusumeciR, SpecialeA, CostanzoR, AnninoA, RagusaS, RapisardaA, PappalardoMS, IaukL. (2003) Berberis aetnensis C. Presl. extracts: antimicrobial properties and interaction with ciprofloxacin. International Journal of Antimicrobial Agents, 22, 48–53.
12.
GibbonsS, UdoEE. (2000) The effect of reserpine, a modulator of multidrug efflux pumps, on the in vitro activity of tetracycline against clinical isolates of methicillin resistant Staphylococcus aureus (MRSA) possessing the tet(K) determinant. Phytotherapy Research, 14, 139–140.
13.
BaeMS, ShinJS, LeeKY, LeeKH, KimYJ. (2014) Long-range transport of biomass burning emissions based on organic molecular markers and carbonaceous thermal distribution. Science of the Total Environment, 466–467, 56–66.
14.
IwasaT, HigashideE, ShibataM. (1971) Studies of validamycins, new antibiotics. 3. Bioassay methods for the determination of validamycin. Journal of Antibiotics (Tokyo), 24, 114–118.
