We have previously reported a wide range of components from Cissus quadrangularis with in vitro effects on lipases and glycosidases. We now report that a preparation of the plant (CQR-300) administered at 300 mg daily was effective in reducing weight, as well as improving blood parameters associated with metabolic syndrome, as well as serotonin levels in obese and overweight individuals.
Beltrán-SánchezH, HarhayMO, HarhayMM, McElligottS. (2013) Prevalence and trends of metabolic syndrome in the adult US population, 1999–2010. Journal of the American College of Cardiology, 62, 697–703.
2.
CornierMA, DabeleaD, HernandezTL, LindstromRC, SteigAJ, StobNR, Van PeltRE, WangH, EckelRH. (2008) The metabolic syndrome. Endocrine Reviews, 29, 777–822.
3.
NtentieFR, NgondiJL, AzantsaKBG, SantyEV, DimodiHT, MbongAM, ChakokamNBM, NguimkengSB, ZambouH, ObenJE. (2014) Urbanization and metabolic syndrome in Cameroon. Alertness on less urbanised areas. Endocrinology & Metabolic Syndrome3, 137. doi:10.4172/2161–1017.1000137.
4.
KaurJ. (2014) A comprehensive review on metabolic syndrome. Cardiology Research and Practice, 2014:943162. doi: 10.1155/2014/943162.
5.
BalkauB, CharlesMA. (1999) Comment on the provisional report from the WHO consultation: European group for the study of insulin resistance (EGIR), Diabetic Medicine, 16, 442–443.
6.
CleemanJI. (2001) Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III). Journal of the American Medical Association, 285, 2486–2497.
7.
AlbertiKG, ZimmetP, ShawJ. (2006) Metabolic syndrome. a new worldwide definition. A consensus statement from the international diabetes federation. Diabetic Medicine, 23, 469–480.
8.
Hasani-RanibarS, NayebiN, LarijaniB, AbdollahiM. (2009) A systematic review of the efficacy and safety of herbal medicines used in the treatment of obesity. World Journal of Gastroenterology, 15, 3073–3085.
9.
AbidovMT, del RioMJ, RamazanovTZ, KlimenovAL, DzhamirzeSH, KalyuzhinOV. (2006) Effects of Aralia mandshurica and Engelhardtia chrysolepis extracts on some parameters of lipid metabolism in women with nondiabetic obesity. Bulletin of Experimental Biology and Medicine, 141, 343–346.
10.
GreenwayFL, De JongeL, BlanchardD, FrisardM, SmithSR. (2004) Effect of a dietary herbal supplement containing caffeine and ephedra on weight, metabolic rate, and body composition. Obesity Research, 12, 1152–1157.
11.
KuateD, EtoundiBC, AzantsaBK, KengneAP, NgondiJL, ObenJE. (2010) The use of LeptiCore in reducing fat gain and managing weight loss in patients with metabolic syndrome. Lipids in Health and Disease, 9:20, doi:10.1186/1476–511X-9–20.
12.
StohsSJ, RaySD. (2013) A review and evaluation of the efficacy and safety of Cissus quadrangularis extracts. Phytotherapy Research, 27, 1107–1114.
13.
SharpH, HollinsheadJ, BartholomewB, ObenJ, WatsonA, NashRJ. (2007) Inhibitory effects of Cissus quadrangularis L. derived components on lipase, amylase and α-glucosidase activity in vitro. Natural Product Communications, 2, 817–822.
14.
ObenJE, EnyegueDM, FomekongGI, SoukontouaYB, AgborGA. (2007) The effect of Cissus quadrangularis (CQR-300) and a Cissus formulation (CORE) on obesity and obesity induced oxidative stress. Lipids in Health and Disease, 6:4, doi:10.1186/1476–511X-6–4.
15.
MishraG, SrivastavaS, NagoriBP. (2010) Pharmacological and therapeutic activity of Cissus quadrangularis: An overview. International Journal of PharmTech Research, 2, 1298–1310.
16.
JakikasemS, LimsiriwongP, KajsongkarmT, SontorntanasartT. (2000) Phytochemical study of Cissus quadrangularis. Thai Journal of Pharmaceutical Science, 24, 25.
17.
ObenJE. KuateD, AgborG, MomoC, TallaX. (2006) The use of a Cissus quadrangularis formulation in the management of weight loss and metabolic syndrome. Lipids in Health and Disease, 5:24, doi: 10.1186/1476- 511X-5–24.
18.
ObenJE, NgondiJL, MomoCN, AgborGA, SobguiCS. (2008) The use of a Cissus quadrangularis/Irvingia gabonensis combination in the management of weight loss: a double blind placebo-controlled study. Lipids in Health and Disease, 7:, 12, doi:10.1186/1476- 511X-7–12.
19.
BrionesAM, NguyenDCA, CalleraGE, YogiA, BurgerD, HeY, CorreaJW, GagnonAM, Gomez-SanchezCE, Gomez-SanchezEP, SoriskyA, OoiTC, RuziokaM, BurnsKD, TouyzRM. (2012) Adipocytes produce aldosterone through calcineurin-dependent signaling pathways: implications in diabetes mellitus-associated obesity and vascular dysfunction. Hypertension, 59, 1069–1078.
20.
ArnoldLM, McElroySL, HudsonJI, WelgeJA, BennettAJ, KeckPE. (2002) A placebo-controlled, randomized trial of fluoxetine in the treatment of binge-eating disorder. Journal of Clinical Psychiatry, 63, 1028–1033.
21.
Oliver-BeverB. (1983) Medicinal plants in tropical West Africa. II. Plants acting on the nervous system. Journal of Ethnopharmacology, 7, 1–93.
22.
BoozerCN, NasserJA, HeymsfieldSB, WangV, ChenG, SolomonJL. (2001) An herbal supplement containing Ma Huang Guarana for weight loss: a randomized, double-blind trial. International Journal of Obesity and Related Metabolic Disorders, 25, 316–324.
23.
AlbertiKG, EckelRH, GrundySM. (2009) Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation, 120, 1640–1645.