A new acetogenin has been isolated from the ethyl acetate extract of leaves and twigs of G. sawtehii (Annonaceae). The structure of compound 1 was identified as sawtehtetronenin on the basis of spectral evidence (UV, IR, MS and 1H, and 13C NMR) and by comparison with related compounds. Sawtehtetronenin was found to be cytotoxic to human hepatocellular carcinoma HepG2 and breast cancer MDA-MB231 cells with IC50 values of 79.3+11.9 μM and 108.1+1.5 μM, respectively. Compound 1 was less toxic to both cell lines when compared with camptothecin, a chemotherapeutic drug.
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GuZ.M., FangX.P., ZengL., SongR., NgJ.H., WoodK.V., SmithD.L., McLaughlinJ.L. (1994) Gonionenin: A new cytotoxic Annonaceae acetogenin from Goniothalamus giganteus and the conversion of mono-THF acetogenin to bis-THF acetogenins. Journal of Organic Chemistry, 59, 3472–3479.
4.
ZengL., ZhangY., YeQ., ShiG., HeK., McLaughlinJ.L., (1996) cis-Gigantrionenin and 4-acetyl gigantetrocin A, two new bioactive Annonaceous acetogenins from Goniothalamus giganteus, and the stereochemistries of acetogenin 1,2,5-triols. Bioorganic and Medical Chemistry, 4, 1271–1279.
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ZengL., ZhangY., McLaughlinJ.L. (1996) Gigantransenin A, B and C, novel mono-THF acetogenins bearing trans double bonds, from Goniothalamus giganteus (Annonaceae). Tetrahedron Letters, 37, 5449–5452.
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YeQ., AlfonsoD., EvertD., McLaughlinJ.L. (1996) Longifolicin, longicoricin, and gigantetroneninone, three novel bioactive mono-tetrahydrofuran Annonaceous acetogenins from Asimina longifolia (Annonaceae). Bioorganic & Medicinal Chemistry, 4, 537–545.
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JiangZ., ChenR.Y., ChenY., YuD.Q. (1998) Donnaienin, a new acetogenin bearing a hydroxylated tetrahydrofuran ring. Journal of Natural Products, 61, 86–88.
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11.
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