A new pyridine derivative, 5-(2′-hydroxypropyl)pyridin-3-ol (1), with seven known alkaloids, 3-hydroxy-5-methyl-5,6-dihydro-7H-cyclopenta[b]pyridin-7-one (2), penicillenol A1 (3), penicillenol A2 (4), a mixture of quinolactacin A1 (5a) and quinolactacin A2 (5b), and a mixture of quinolactacin C1 (6a) and quinolactacin C2 (6b), were isolated from the culture broth of a marine-derived fungus Xylariaceae sp. SCSGAF0086. Their structures were elucidated by spectroscopic methods. Compound 2 showed weak antimicrobial activity against Bacillus subtilis, and a mixture of 6a and 6b exhibited strong antifouling activity toward Bugula neritina larval settlement.
ZhengCJ, ShaoCL, GuoZY, ChenJF, DengDS, YangKL, ChenYY, FuXM, SheZG, LinYC, WangCY. (2012) Bioactive hydroanthraquinones and anthraquinone dimers from a soft coral-derived fungus Alternaria sp. Journal of Natural Products, 75, 189–197
2.
ZhuangY, TengX, WangY, LiuP, LiG, ZhuW. (2011) New quinazolinone alkaloids within rare amino acid residue from coral associated fungus Aspergillus versicolor LCJ-5-4. Organic Letters, 13, 1130–1133
3.
ShaoCL, WangCY, WeiMY, GuYC, SheZG, QianPY, LinYC. (2011) Aspergilones A and B, two benzylazaphilones with an unprecedented carbon skeleton from the gorgonian-derived fungus Aspergillus sp. Bioorganic & Medicinal Chemistry Letters, 21, 690–693
4.
HawasUW, ShaabanM, ShaabanKA, SpeitlingM, MaierA, KelterG, FiebigHH, MeinersM, HelmkeE, LaatschH. (2009) Mansouramycins A-D, cytotoxic isoquinolinequinones from a marine Streptomycete. Journal of Natural Products, 72, 2120–2124
5.
KönigWA, HahnH, RathmannR, HassW, KeckeisenA, HagenmaierH, BormannC, DehlerW, ZähnerH (1986) Three novel amino acids from the nikkomycin complex - structure elucidation and synthesis. European Journal of Organic Chemistry, 3, 407–421
6.
PengXP, WangY, LiuPP, HongK, ChenH, YinX, ZhuWM. (2011) Aromatic compounds from the halotolerant fungal strain of Wallemia sebi PXP-89 in a hypersaline medium. Archives of Pharmacol Research, 34, 907–912.
7.
LinZJ, LuZY, ZhuTJ, FangYC, GuQQ, ZhuWM. (2008) Penicillenols from Penicillium sp. GQ-7, an endophytic fungus associated with Aegiceras corniculatum. Chemical and Pharmaceutical Bulletin, 56, 217–221
8.
WonGK, NanKS, IckDY. (2001) Quinolactacins Al and A2, new acetylcholinesterase inhibitors from Penicillium citrinum. The Journal of Antibiotics, 54, 831–835
9.
ZhangXQ, JiangWJ, SuiZH. (2003) Concise enantioselective syntheses of quinolactacins A and B through alternative winterfeldt oxidation. Journal of Organic Chemistry, 68, 4523–4526
10.
ClarkB, CaponRJ, LaceyE, TennantS, GillJH. (2006) Quinolactacins revisited: from lactams to imide and beyond. Organic & Biomolecular Chemistry, 4, 1512–1519
11.
AcarJF. (1980) The disc susceptibility test. In Antibiotics in laboratory medicine. LorianV. (Ed.). Williams and Wilkins, Baltimore, 24–54.
12.
HeF, HanZ, PengJ, QianPY, QiSH. (2009) Antifouling indole alkaloids from two marine derived fungi. Natural Product Communication, 8, 329–332
13.
ZhangXY, BaoJ, WangGH, HeF, XuXY, QiSH. (2012) Diversity and antimicrobial activity of culturable fungi isolated from six species of the South China sea gorgonians. Microbial Ecology, 64, 617–627.
