From the ethyl acetate extract of the soft coral Sinularia arborea, a new cembrane-type diterpenoid, arbolide C (1), along with (+)-sarcophytol T (2), an enantiomer of the known cembrane, sarcophytol T, were isolated. The structures of compounds 1 and 2 were established by spectroscopic methods and 1 was found to display an inhibitory effect on the release of elastase by human neutrophils.
(a) ChenW.T., LiY., GuoY.W. (2012) Terpenoids of Sinularia soft corals: chemistry and bioactivity. Acta Pharmaceutica Sinica B, 2, 227–237; (b) Yang B, Zhou XF, Lin XP, Liu J, Peng Y, Yang XW, Liu Y. (2012) Cembrane diterpenes chemistry and biological properties. Current Organic Chemistry, 16, 1512–1539.
2.
(a) KönigG.M., WrightA.D. (1998) New cembranoid diterpenes from the soft coral Sarcophyton ehrenbergi. Journal of Natural Products, 61, 494–496; (b) Chen KH, Dai CF, Lu MC, Li JJ, Chen JJ, Chang YC, Su YD, Wang WH, Sung PJ. (2013) Secondary metabolites from the soft coral Sinularia arborea. Marine Drugs, 11, 3372–3380; (c) Chen KH, Dai CF, Hwang TL, Chen CY, Li JJ, Chen JJ, Wu YC, Sheu JH, Wang WH, Sung PJ. (2014) Discovery of novel diterpenoids from Sinularia arborea. Marine Drugs, 12, in press.
3.
RaviB.N., FaulknerD.J. (1978) Cembranoid diterpenes from a South Pacific soft coral. The Journal of Organic Chemistry, 43, 2127–2131.
