A new hemiketal eunicellin-based diterpenoid, cladieunicellin H (1), was isolated from an Indonesian octocoral identified as Cladiella sp. The structure of 1 was determined by spectroscopic methods. This compound was found to display moderate inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.
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Diphenylene indonium (DPI) and elastatinal were used as reference compounds in anti-inflammatory activity testing. DPI displayed an inhibitory effect on superoxide anion generation (IC50 = 0.8 μg/mL), and elastatinal exhibited an inhibitory effect on elastase release (IC50 = 31 μg/mL) by human neutrophils, respectively.
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