A new 6-hydroperoxyeunicellin diterpenoid, designated as cladieunicellin J (1), was isolated from an octocoral Cladiella sp., and its structure elucidated by spectroscopic methods. Compound 1 was found to exhibit cytotoxicity toward CCRF-CEM human T-cell acute lymphoblastic leukemia.
ChenYH, TaiCY, KuoYH, KaoCY, LiJJ, HwangTL, FangLS, WangWH, SheuJH, SungPJ. (2011) Cladieunicellins A-E, new eunicellins from an Indonesian soft coral Cladiella sp. Chemical & Pharmaceutical Bulletin, 59, 353–358
2.
ChenYH, TaiCY, SuYD, ChangYC, LuMC, WengCF, SuJH, HwangTL, WuYC, SungPJ. (2011) Discovery of new eunicellins from an Indonesian octocoral Cladiella sp. Marine Drugs, 9, 934–943
3.
ChenYH, HwangTL, SuYD, ChangYC, ChenYH, HongPH, HuLC, YenWH, HsuHY, HuangSJ, KuoYH, SungPJ. (2012) New 6-hydroxyeunicellins from a soft coral Cladiella sp. Chemical & Pharmaceutical Bulletin, 60, 160–163
4.
ChenYH, TaiCY, HwangTL, SungPJ. (2012) Cladieunicellin H, a new hemiketal eunicellin-based diterpenoid from the octocoral Cladiella sp. Natural Product Communications, 7, 481–484
5.
ChenTH, LuMC, ChangYC, SuYD, ChenYH, LinNC, FangLS, WuYC, SungPJ. (2013) Discovery of new eunicellin-based diterpenoids from a Formosan soft coral Cladiella sp. Marine Drugs, 11, 4585–4593
6.
ShihFY, ChenTH, LuMC, ChenWF, WenZH, KuoYH, SungPJ. (2013) Cladieunicellins K and L, new eunicellin-based diterpenoids from an octocoral Cladiella sp. International Journal of Molecular Sciences, 14, 21781–21789.
7.
WelfordAJ, CollinsI. (2011) The 2,11-cyclized cembranoids: cladiellins, asbestinins, and briarellins (period 1998-2010). Journal of Natural Products, 74, 2318–2328
8.
RadhikaP. (2006) Chemical constituents and biological activities of the soft corals of genus Cladiella: a review. Biochemical Systematic and Ecology, 34, 781–789.
9.
LinMC, ChenBW, HuangCY, DaiCF, HwangTL, SheuJH. (2013) Eunicellin-based diterpenoids from the Formosan soft coral Klyxum molle with inhibitory activity on superoxide generation and elastase release by neutrophils. Journal of Natural Products, 76, 1661–1667
10.
ChenBW, WuYC, ChiangMY, SuJH, WangWH, FanTY, SheuJH. (2009) Eunicellin-based diterpenoids from the cultured soft coral Klyxum simplex. Tetrahedron, 65, 7016–7022
FabriciusK, AldersladeP. (2001) Soft corals and sea fans—A comprehensive guide to the tropical shallow-water genera of the Central-West Pacific, the Indian Ocean and the Red Sea, 1st ed. Australian Institute of Marine Science, Queensland, Australia. 84–85.
13.
ScudieroDA, ShoemakerRH, PaullK.D, MonksA, TierneyS, NofzigerTH, CurrensMJ, SeniffD, BoydMR. (1988) Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines. Cancer Research, 48, 4827–4833.
