A controlled study was conducted to determine the efficiency of a topical ointment prepared from the stem extract of Morinda citrifolia against cutaneous leishmaniasis. Similarly, the in vitro antileishmanial activity of morindicone and morinthone isolated from the extract were investigated against Leishmania major. These compounds displayed good activity. Out of 40 patients, 50% showed an excellent response and 30% exhibited good improvement.
Gabriel GrimaldiJR, TeshRB. (1993) Leishmaniasis of New World: current concepts and implication for future research. Clinical Microbiology Reviews, 6, 230–250;
2.
SinghS, SivakumarR. (2004) Challenges and new discoveries in the treatment of leishmaniasis. Journal of Infection Chemotherapy, 10, 307–315.
3.
SundarS, RaiM. (2002) Advances in the treatment of leishmaniasis. Current Opinion in Infectious Diseases, 15, 593–598.
4.
SoomroFR, PathanGM, AbbasiP, BhattiNS, HussainJ, SarwarG, BhuttoAM, HashiguchiY. (2005) Clinical trial of 20% Lippia nodiflora (bucan) topical ointment for cutaneous leishmaniasis; a preliminary trial. Journal of Pakistan Association of Dermatologists, 15, 108–112.
5.
RochaLG, AlmeidaJRGS, MacêdoRO, Barbosa-FilhoJM. (2005) A review of natural products with antileishmanial activity. Phytomedicine, 12, 514–535;
6.
WangMY, WestBJ, JensenCJ, NowickiD, SuC, PaluAK, AndersonG. (2002) Morinda citrifolia (Noni): a literature review and recent advances in Noni research. Acta Pharmacolgica Sinica, 23, 1127–1141.
7.
SastriBN. (1962) The Wealth of India, Vol. 6. Council of Scientific and Industrial Research, New Delhi, India. 423- 424
8.
JayaweeraDMA. (1982) Medicinal Plants. The National Science Council of Sri Lanka, Colombo, Vol. 4, 280–281.
9.
NizamuddinS, QaiserM. (1989) Flora of Pakistan. Department of Botany, University of Karachi, Vol. 190, 113–114.
10.
BashirA, AliN, BashirS, ChoudharyMI. (2009) Biological activities of aerial parts of Tylophora hirsute Wall. African Journal of Biotechnology, 8, 4627–4631;
11.
SabinaH, TasneemS, Samreen KausarY, ChoudharyMI, AliyaR. (2005) Antileishmanial activity in the crude extract of various seaweeds from the coast of Karachi, Pakistan. Pakistan Journal of Botany, 37, 163–168;
12.
SiddquiBS, SattarFA, BegumS, GulzarT, AhmedF. (2007) Chemical constituents from the stems of Morinda citrifolia Linn. Archives of Pharmacal Research, 30, 793–798.
