The crude methanolic extract obtained from C. erythraea resin was chromatographed on silica gel with solvent of increasing polarity. The extract and fractions were evaluated for cytotoxicity and antiviral activity [parainfluenza type 3 virus (PIV3)] by plaque forming units (PFU) reduction assay using HEp-2 cells (human larynx epidermoid carcinoma cell line). From the active fraction, five compounds were isolated and tested. Only two of these showed anti-PIV3 activity with a selectivity index (SI) of 66.6 and 17.5, respectively. Both the compounds are furanosesquiterpenoids.
KaiserL, CouchRB, GalassoGJ, GlezenWP, WebsterRG, WrightPF, HaydenFG. (1999) First International Symposium on Influenza and Other Respiratory Viruses: summary and overview: Kapalua, Maui, Hawaii, December 4–6, 1998. Antiviral Research, 42, 149–176.
2.
WilliamsBG, GouwsE, Boschi-PintoC, BryceJ, DyeC. (2002) Estimates of world-wide distribution of child deaths from acute respiratory infections. The Lancet Infectious Diseases, 2, 25–32.
3.
PaleseP. (2004). Influenza: old and new threats. Nature Medicine, 10, S82-S87.
MarcotullioMC, SantiC, Oball-Mond MwankieGN, CuriniM. (2009) Chemical composition of the essential oil of Commiphora erythraea. Natural Product Communications, 4, 1751–1754.
MaradufuA. (1982) Furanosesquiterpenoids of Commiphora erythraea and C. myrrh. Phytochemistry, 21, 677–680.
8.
Asif SaeedM, SabirAW. (2004) Antibacterial activities of some constituents from oleo-gum-resin of Commiphora mukul. Fitoterapia, 75, 204–208.
9.
DolaraP, CorteB, GhelardiniC, PuglieseAM, CerbaiE, MenichettiS, Lo NostroA. (2000) Local anaesthetic, antibacterial and antifungal properties of sesquiterpenes from myrrh. Planta Medica, 66, 356–358.
10.
TanakaK, KubaY, InaA, WatanabeH, KomatsuK. (2008) Prediction of cyclooxygenase inhibitory activity of Curcuma rhizome from chromatograms by multivariate analysis. Chemical & Pharmaceutical Bullettin, 56, 936–940.
11.
HawthorneJD, AlbrechtP. (1981) Sensitive plaque neutralization assay for Parainfluenza virus types 1, 2, and 3 and Respiratory syncytial virus. Journal of Clinical Microbiology, 13, 730–737.
12.
Van der MeulenK, GarréB, CroubelsS, NauwynckH. (2006) In vitro comparison of antiviral drugs against feline herpesvirus 1. BMC Veterinary Research, 2, 13 doi:10.1186/1746-6148-2-13.
