Two novel cyclopeptides, xylarotides A (1), and B (2), and one novel nonenolide, xylarolide (3), along with two known compounds, coriloxin (4), and 2-hydroxy-3-methoxy-5-methyl-p-benzoquinone (5) were isolated from the fungal strain Xylaria sp. 101. This strain was isolated from the fruiting body of Xylaria sp. collected in Gaoligong Mountain, Yunnan Province. The chemical structures were elucidated by spectroscopic analyses, including 1D- and 2D-NMR spectroscopic experiments, and on the basis of HR-Q-TOF mass spectrometry. Antibacterial assays of 1 - 3 were carried out; no effects on the growth of the tested bacteria and yeast were observed.
CovalSJPuarMSPhifeDWTerraccianoJSPatelM. (1995) SCH57404, an antifungal agent possessing the rare sodaricin skeleton and a tricyclic sugar moiety. The Journal of Antibiotics, 48, 1171–1172.
2.
SmithCJMorinNRBillsGFDombrowskiAWSalituroGMSmithSKZhaoA, MacNeilDJ. (2002) Novel sesquiterpenoids from the fermentation of Xylaria persicaria are selective ligands for the NPY Y5 receptor. Journal of Organic Chemistry, 67, 5001–5004.
3.
DeyrupSTGloerJBO'DonnellK, WicklowDT. (2007) Kolokosides A-D: triterpenoid glycosides from a Hawaiian isolate of Xylaria sp. Journal of Natural Products, 70, 378–382.
4.
HuZYLiYYHuangYJSuWJShenYM. (2008) Three new sesquiterpenoids from Xylaria sp. NCY2. Helvetica Chimica Acta, 91, 46–52.
5.
LiYYHuZYLuCHShenYM. (2010) Four new terpenoids from Xylaria sp. 101. Helvetica Chimica Acta, 93, 796–802.
6.
LinYCWuXYFengS, JiangGGZhouSNVrijmoedLLP, JonesEBG. (2001) A novel N-cinnamoylcyclopeptide containing an allenic ether from the fungus Xylaria sp. (strain # 2508) from the South China Sea. Tetrahedron Letters, 42, 449–451.
7.
HuangH, SheZ, LinY, VrijmoedLLLinW. (2007) Cyclic peptides from an endophytic fungus obtained from a mangrove leaf (Kandelia candel). Journal of Natural Products, 70, 1696–1699.
8.
O'HaganaD, RogersSVDuffinGREdwardsRL. (1992) Biosynthesis of the fungal polyketide, cubensic acid from Xylaria cubensis. Tetrahedron Letters, 33, 5585–5588.
9.
BoonphongS, KittakoopP, IsakaM, PittayakhajonwutD, TanticharoenM, ThebtaranonthY. (2001) Multiplolides A and B, new antifungal 10-membered lactones from Xylaria multiplex. Journal of Natural Products, 64, 965–967.
10.
JayasuriyaH, HerathKBOndeykaJGPolishookJDBillsGFDombrowskiAWSpringerMSSicilianoS, MalkowitzL, SanchezM, GuanZ, TiwariS, StevensonDWBorrisRPSinghSB. (2004) Isolation and structure of antagonists of chemokine receptor (CCR5). Journal of Natural Products, 67, 1036–1038.
11.
HealyPCHockingA, Tran-DinhN, PittJIShivasRGMitchellJKKotiwM, DavisRA. (2004) Xanthones from a microfungus of the genus Xylaria. Phytochemistry, 65, 2373–2378.
12.
DavisRAPierensGK. (2006) 1H and 13C NMR assignments for two new xanthones from the endophytic fungus Xylaria sp. FRR 5657. Magnetic Resonance in Chemistry, 44, 966–968.
13.
LinY, WuX, FengS, JiangG, LuoJ, ZhouS, VrijmoedLLJonesEBKrohnK, SteingroverK, ZsilaF. (2001) Five unique compounds: xyloketals from mangrove fungus Xylaria sp. from the South China Sea coast. Journal of Organic Chemistry, 66, 6252–6256.
14.
ShionoY, MurayamaT, TakahashiK, OkadaK, KatohdaS, IkedaM. (2005) Three oxygenated cyclohexenone derivatives produced by an endophytic fungus. Bioscience, Biotechnology, and Biochemistry, 69, 287–292.
15.
Rivero-CruzJFMaciasM, Cerda-Garcia-RojasCMMataR. (2003) A new phytotoxic nonenolide from Phoma herbarum. Journal of Natural Products, 66, 511–514.
16.
DuXPLuCH; LiYYZhengZHSuWJShenYM. (2008) Three new antimicrobial metabolites of Phomopsis sp. Journal of Antibiotics, 61, 250–253.
