The University of Alabama in Huntsville Natural Products Research Group has been investigating the phytopharmaceutical potential of tropical rainforest higher plants from the Monteverde region of northwestern Costa Rica for the past twenty years. The group has focused primarily on anticancer agents, antimicrobial agents, and antiparasitic agents. This review presents an overview of some of our efforts in natural products drug discovery from Monteverde, Costa Rica.
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SetzerWNStokesSLBansalA, HaberWACaffreyCRHansellE, McKerrowJH. (2007) Chemical composition and cruzain inhibitory activity of Croton draco bark essential oil from Monteverde, Costa Rica. Natural Product Communications, 2, 685–689.
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SetzerWN. (2006) Chemical compositions of the bark essential oils of Croton monteverdensis and Croton niveus from Monteverde, Costa Rica. Natural Product Communications, 1, 567–572.
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StokesSLColeRARangelovaMPHaberWA. (2007) Cruzain inhibitory activity of the leaf essential oil from an undescribed species of Eugenia from Monteverde, Costa Rica. Natural Product Communications, 2, 1211–1213.
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SetzerWNSetzerMCMoriarityDMBatesRBHaberWA. (1999) Biological activity of the essential oil of Myrcianthes sp. nov. “black fruit” from Monteverde, Costa Rica. Planta Medica, 65, 468–469.
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WuX, VoglerB, HaberWASetzerWN. (2006) A phytochemical investigation of Nectandra membranacea from Monteverde, Costa Rica. Natural Product Communications, 1, 465–468.
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TakakuS, HaberWASetzerWN. (2007) Leaf essential oil composition of 10 species of Ocotea (Lauraceae) from Monteverde, Costa Rica. Biochemical Systematics and Ecology, 35, 525–532.
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BansalA, MoriarityDMTakakuS, SetzerWN. (2007) Chemical composition and cytotoxic activity of the leaf essential oil of Ocotea tonduzii from Monteverde, Costa Rica. Natural Product Communications, 2, 781–784.
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RichmondJDAgiusBRWrightBSHaberWAMoriarityDMSetzerWN. (2009) Essential oil compositions and cytotoxic activities of Dendropanax capillaris, Oreopanax nubigenus, and Schefflera rodrigueziana from Monteverde, Costa Rica. Natural Product Communications, 4, 271–274.
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SetzerWNParkG, AgiusBRStokesSLWalkerTMHaberWA. (2008) Chemical compositions and biological activities of leaf essential oils of twelve species of Piper from Monteverde, Costa Rica. Natural Product Communications, 3, 1367–1374.
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PalazzoMCAgiusBRWrightBSHaberWAMoriarityDMSetzerWN. (2009) Chemical compositions and cytotoxic activities of leaf essential oils of four Lauraceae tree species from Monteverde, Costa Rica. Records of Natural Products, 3, 32–37.
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SetzerWNAgiusBRWalkerTMMoriarityDMHaberWA. (2008) Germacrone dominates the leaf oil of Siparuna grandiflora from Monteverde, Costa Rica. Natural Product Communications, 3, 267–270.
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SchmidtJMSetzerWN. (2006) Analysis of the leaf essential oil of Stauranthus perforatus from Monteverde, Costa Rica. Natural Product Communications, 1, 201–204.
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HaberWAAgiusBRStokesSLSetzerWN. (2008) Bioactivity and chemical composition of the leaf essential oil of Talauma gloriensis Pittier (Magnoliaceae) from Monteverde, Costa Rica. Records of Natural Products, 2, 1–5.
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SchmidtJMNolettoJAVoglerB, SetzerWN. (2006) Abaco bush medicine: Chemical composition of the essential oils of four aromatic medicinal plants from Abaco Island, Bahamas. Journal of Herbs, Spices & Medicinal Plants, 12, 43–65.
