Szentiamide (1) a new cyclic hexadepsipeptide was isolated from the culture broth of the entomopathogenic bacterium Xenorhabdus szentirmaii DSM 16338T. The structure was elucidated by analysis of one- and two-dimensional NMR spectra and high resolution mass spectrometry. The amino acids were determined to be D-leucine, L-threonine, D-phenylalanine, D-valine, L-tyrosine and L-tryptophane after hydrolysis and derivatization with D-FDVA [Nα-(2,4-dinitro-5-fluorophenyl)-D-valinamide].
LengyelK, LangE, FodorA., SzállásE, SchumannP, StackebrandtE. (2005) Description of four novel species of Xenorhabdus, family Enterobacteriaceae: Xenorhabdus budapestensis sp. nov., Xenorhabdus ehlersii sp. nov., Xenorhabdus innexi sp. nov., and Xenorhabdus szentirmaii sp. nov. Systematic and Applied Microbiology, 28, 115–122;
2.
BodeHB. (2009) Entomopathogenic bacteria as a source of secondary metabolites. Current Opinion in Chemical Biology, 13, 224–230;
3.
BowenD, RocheleauTA., BlackburnM, AndreevO, GolubevaE, BhartiaR, ffrench-ConstantRH. (1998) Insecticidal toxins from the bacterium Photorhabdus luminescens. Science, 280, 2129;
4.
BrownSE, CaoAT, HinesER, AkhurstRJ, EastePD. (2004) A novel secreted protein toxin from the insect pathogenic bacterium Xenorhabdus nematophila, The Journal of Biological Chemistry, 15, 14595–1460;
5.
LangG, KalvelageT, PetersA, WieseJ, ImhoffJF. (2008) Linear and cyclic peptides from the entomopathogenic bacterium Xenorhabdus nematophilus. Journal of Natural Products, 71, 1074–1077;
6.
LiJ, HuK, WebsterJM. (1998) Antibiotics from Xenorhabdus spp. and Photorhabdus spp. (Enterobacteriacea) (Review). Chemistry of Heterocyclic Compounds, 34, 1331–1339.
7.
BrachmannAO, ForstS, FurganiGM, FodorA, BodeHB. (2006) Xenofuranones A and B: phenylpyruvate dimers from Xenorhabdus szentirmaii. Journal of Natural Products, 69, 1830–1832;
8.
DemainAL, FangA. (2000) The natural functions of secondary metabolites. Advances in biochemical Engineering/ Biotechnology, 69, 1–33;
9.
LiJ, ChenG, WebsterJM. (1995) Antimicrobial metabolites from a bacterial symbiont. Journal of Natural Products, 58, 1081–1086.
10.
GualtieriM, AumelasA, ThalerJ. (2009) Identification of a new antimicrobial lysine-rich cyclolipopeptide family from Xenorhabdus nematophila. Journal of Antibiotics, 62, 295–302;
11.
ImhoffJF, LangG, KajahnI, PetersA, WieseJ. (2009) Herstellung und Verwendung antitumoraler, antibiotischer und insektizider Cyclodepsipeptide. Patent DE 10 2009 025 119 A1.
12.
BodeHB. (2010) Insektenpathogene Bakterien als Quelle neuer Naturstoffe. Biospektrum, 16, 266–269.
13.
SchoenafingerG, SchrackeN, LinneU, MarahielMA. (2006) Formylation domain: an essential modifying enzyme for the nonribosomal biosynthesis of linear gramicidin. Journal of the American Chemical Society, 128, 7406–7407.
14.
SchneemannI, KajahnI, OhlendorfB, ZineckerH, ErhardA, NagelK, WieseJ, ImhoffJF. (2010) Mayamycin, a cytotoxic polyketide from a Streptomyces strain isolated from the marine sponge Halichondria panicea. Journal of Natural Products, 73, 1309–1312;
15.
BakiA., BielikA, MolnárL, SzendreiG, KeserüGM. (2007) A high throughput luminescent assay for Glycogen Synthase Kinase-3β Inhibitors. ASSAY and Drug Development Technologies, 5, 75–83.
