Two new acyclic diterpenes, melidianolic acids A (1) and B (2), have been isolated from the bark of Aphanamixis grandifolia. Their structures were elucidated on the basis of spectroscopic and chemical methods. Melidianolic acids A (1) and B (2) showed antimalarial activity against Plasmodium falciparum 3D7 with IC50 of 6.1 and 7.3 μg/mL, respectively.
AmitR, ShailendraS. (2006) Limonoids: Overview of Significant Bioactive Triterpenes Distributed in Plants Kingdom. Biological & Pharmaceutical Bulletin, 29, 191–201.
2.
NishizawaM, NishideH, HayashiY, KoselaS. (1982) The structure of Lansioside A: A novel triterpene glycoside with amino-sugar from Lansium domesticum. Tetrahedron Letters, 23, 1349–1350.
3.
NishizawaM, InoueA, SastrapradjaS, HayashiY. (1983) (+)-8-Hydroxycalamenene: A fish-poison principle of Dysoxylum acutangulum and D. Alliaceum. Phytochemistry, 22, 2083–2085.
4.
NishizawaM, InoueA, HayashiY, SastrapradjaS, KoselaS, IwashitaT. (1984) Structure of aphanamols I and II. The Journal of Organic Chemistry, 49, 3660–3662.
5.
PolonskyJ, VaronZ, ArnouxB, PascardC, PettirGR, SchmidJH, LangeLM. (1978) Antineoplastic agents. 57. Isolation and structure of aphanastatin. Journal of the American Chemical Society, 100, 2575–2576.
6.
PolonskyJ, VaronZ, ArnouxB, PascardC, PettirGR, SchmidJM. (1978) Antineoplastic agents. 61. Isolation and structure of amoorastatin. Journal of the American Chemical Society, 100, 7731–7734.
7.
PolonskyJ, VaronZ, MarazanoC, ArnouxB, PettirGR, SchmidJM, OchiM, KotsukiH. (1979) The structure of amoorastatone and the cytotoxic limonoid 12-hydroxyamoorastatin. Experientia, 35, 987–989.
8.
PerezAL, OrtegaA, VivarAR. (1988) An acyclic diterpene and sesquiterpene lactones from Tithonia pedunculata. Phytochemistry, 27, 3897–3901.
9.
GuerreiroE. (1986) Heliangolides and acyclic diterpene from Viguiera gilliesii. Phytochemistry, 25, 748–750.
10.
VallsR, BanaigsB, FranciscoC, CodomierL, CaveA. (1986) An acyclic diterpene from the brown alga Bifurcaria bifurcata. Phytochemistry, 25, 751–752.
11.
RangkaewN, SuttisriR, MoriyasuM, KawanishiK. (2009) A new acyclic diterpene acid and bioactive compounds from Knema glauca. Archives of Pharmacal Research, 32, 685–692.
TragerW, JensenJB. (1976) Human malaria parasites in continuous culture. Science, 193, 673–675.
14.
BudimuljaAS, SyafruddinTP, WilariatP, MarzukiS. (1977) The sensitivity of Plasmodium protein synthesis to prokaryotic ribosomal inhibitors. Molecular and Biochemical Parasitology, 84, 137–141.
