The biotransformation of (-)-nopol benzyl ether (5) by Aspergillus Niger TBUYN-2 and A. niger Tiegh CBSYN was investigated. A. niger biotransformed 5 to afford (-)-4-oxonopol-2’,4’-dihydroxybenzyl ether (6), and (-)-4-oxonopol (7) as main products. Compound 6 showed strong antioxidant activity (IC50 30.2 μM), which was very similar to that of butyl hydroxyl anisol (BHA).
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NomaY, AsakawaY. (2009) Biotransformation of monoterpenoids by microorganisms, insects, and mammals In Handbook of essential oils. BaserHC, BuchbauerG. (Eds). Taylor and Francis, Boca Raton, Florida, USA. 585–736.
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NomaY, AsakawaY. (2010) Biotransformation of monoterpenoids. In Comprehensive Natural Products II, Chemistry and Biology Mander L, LuiH-W. (Eds). Elsevier, Oxford, UK.669–801.
6.
NomaY, AsakawaY. (2005) Microbial transformation of (-)-myrtenol and (-)-nopol, 49th Symposium on the Chemistry of Terpenes, Essential Oils, and Aromatics, abstract paper, pp.78–80 (Fukui).
