Grandivittin (1), agasyllin (2), aegelinol benzoate (3) and felamidin (20), four natural coumarins isolated from Ferulago campestris, and several synthetic ester derivatives of aegelinol (4) were tested against four tumor cell lines. Some of them were shown to be marginally cytotoxic against the A549 lung cancer cell line.
BoulusL. (1983) Medicinal plants of North-Africa MI; Algonae: Michigan, USA, p. 183.
2.
DemetzosC, PerdetzoglouD, GazouliM, TanK, EconomakisC. (2000) Chemical analysis and antimicrobial studies on three species of Ferulago from Greece. Planta Medica, 66, 560–563.
3.
NavesY R. (1967) Études sur les matières végétales volatiles CCIII (1). Présence de n-undécatriènes-1,3,5 dans 1′huile essentielle de la gomme-résine de Galbanum. Bulletin de la Société Chimique de France, 3152–3154.
4.
BasileA, SorboS, SpadaroV, BrunoM, MaggioA, FaraoneN, RosselliS. (2009) Antimicrobial and antioxidant activities of coumarins from the roots of Ferulago campestris (Apiaceae). Molecules, 14, 939–952.
5.
HataK, SanoK. (1966) The constitution of decursin, a new coumarin isolated from the root of Angelica decursiva Fr. et Sav. (Umbelliferae). Tetrahedron Letters, 1461–1465.
6.
KonoshimaM, ChiHJ, HataK. (1967) Coumarins from the root of Angelica gigas Nakai. Chemical and Pharmaceutical Bulletin, 16, 1139–1140.
7.
ItokawaH, YunY, MoritaH, TakeyaK, LeeSR. (1994) Cytotoxic coumarins from roots of Angelica gigas Nakai. Natural Medicines, 48, 334–335.
8.
YimD, SinghR, AgarwalC, LeeS, ChiH, AgarwalR. (2005) A novel anticancer agent, decursin, induces G1 arrest and apoptosis in human prostate carcinoma cells. Cancer Research, 65, 1035–1044.
9.
ChoiSS, HanKJ, LeeJK, LeeHK, HanEJ, KimDH, SuhH-W. (2003) Antinociceptive mechanisms of orally administered decursinol in the mouse. Life Sciences, 73, 471–485.
AhnKS, SimWS, LeeIK, SeuYB, KimIH. (1997) Decursinol angelate: A cytotoxic and protein kinase C activating agent from the root of Angelica gigas. Planta Medica63, 360–361.
12.
YongYL, LeeS, JingLJ, HyeSYC. (2003) Platelet anti-aggregatory effects of coumarins from the roots of Angelica genuflexa and A. gigas. Archives of Pharmacal Research, 26, 723–726.
13.
LeeS, LeeYS, JungSH, ShinKH, KimBK, KangSS. (2003) Antioxidant activities of decursinol angelate and decursin from Angelica gigas roots. Natural Product Sciences, 9, 170–173.
14.
LeeS, YeonSL, SangHJ, KukHS, KimBK, SamSK. (2003) Anti-tumor activities of decursinol angelate and decursin from Angelica gigas. Archives of Pharmacal Research26, 727–730.
15.
HyeonHK, SungSB, JinSC, HanH, KimIH. (2005) Involvement of PKC and ROS in the cytotoxic mechanism of anti-leukemic decursin and its derivatives and their structure-activity relationship in human K562 erythroleukemia and U937 myeloleukemia cells. Cancer Letters, 223, 191–201.
16.
LeeS, ShinDS, JuSK, OhKB, SamSK. (2003) Antibacterial coumarins from Angelica gigas roots. Archives of Pharmacal Research, 26, 449–452.
17.
KangSY, LeeKY, SungSH, KimYC. (2005) Four new neuroprotective dihydropyranocoumarins from Angelica gigas. Journal of Natural Products68, 56–59.
18.
RosselliS, MaggioA, EiroaC, FormisanoC, BrunoM, IraceC, MaffettoneC, MascoloN. (2008) Cytotoxic activity of diterpenoids isolated from the aerial parts of Elaeoselinum asclepium (L.) Bertol. subsp. meoides (Desf.) Fiori (Apiaceae). Planta Medica, 74, 1285–1287.
19.
BrunoM, RosselliS, MaggioA, RaccugliaRA, BastowKF, LeeKH. (2005) Cytotoxic activity of natural and synthetic guaianolides. Journal of Natural Products, 68, 1042–1046.
20.
BrunoM, RosselliS, MaggioA, RaccugliaRA, BastowKF, WuCC, LeeKH. (2005) Cytotoxic activity of some natural and synthetic sesquiterpene lactones. Planta Medica, 71, 1176–1178.
21.
RosselliS, BrunoM, MaggioA, BelloneG, ChenTH, BastowKF, LeeKH. (2007) Cytotoxyc activity of some natural and synthetic kauranes. Journal of Natural Products, 70, 347–352.
22.
KopczackiP, GumulkaM, MassnykM, GrabarczykH, NowakG, DaniewskiWM. (2001) Synthesis and antifeedant properties of N-benzoylphenylisoserinates of Lactarius sesquiterpenoid alcohols. Phytochemistry, 58, 775–787.