Dittrichia viscosa is a plant widely distributed in the Mediterranean region. This species and its components present a broad range of biological activities (for example, anti-inflammatory, antifungal, antiulcer, antiviral, antiparasitic), which are reviewed. Extracts of the species are particularly rich in terpenoids, in particular eudesmane acids, notably ilicic acid (45) and α-costic acid (44). Flavonoids are also abundant, especially during flowering.
MartinMJ, Alarcon de la LastraC, MarhuendaE, JimenezB. (1988) Preliminary study of the anti-inflammatory action of Dittrichia viscosa (L.) W. Greuter. Annales Pharmaceutiques Francaises, 46, 309–312
2.
Font QuerP. (1988) Plantas Medicinales. El Dioscórides Renovado. 11th ed., Labor SA, Barcelona, 788–789.
3.
ShtacherG, KashmanY. (1971) Chemical investigation of volatile constituents of Inula viscosa Ait. Tetrahedron, 27, 1343–1349.
LauroL, RolihC. (1990) Studies on the oil of Inula viscosa Ait. Bolletino-Societa Italiana di Biologia Sperimentale, 66, 829–834.
6.
Perez-AlonsoMJ, Velasco-NegueruelaA, DuruME, HarmandarM, VallejoMCG. (1996) Composition of the volatile oil from the aerial parts of Inula viscosa (L.) Aiton. Flavour and Fragrance Journal, 11, 349–351
7.
KaramenderesC, ZeybekU. (2000) Composition of the essential oils of Inula viscosa, I. graveolens, and I. helenium subsp. turcoracemosa. Journal of Faculty of Pharmacy of Istanbul University, 33, 1–5.
8.
Mueller-RiebauF, BergerB, YegenO. (1995) Chemical composition and fungitoxic properties to phytopathogenic fungi of essential oils of selected aromatic plants growing wild in Turkey. Journal of Agricultural and Food Chemistry, 43, 2262–2266
9.
ChahbounJ, CasabiancaH, JeannotV. (1998) Identification of the characteristic odorants in the essential oil of Inula viscosa. Rivista Italiana EPPOS, 701–707.
10.
SanzJF, FerrandoC, MarcoJA. (1991) Oxygenated nerolidol esters and eudesmane acids from Inula viscosa. Phytochemistry, 30, 3653–3655
11.
GrandeM, BellidoIS, TorresP, PieraF. (1992) 9-Hydroxynerolidol esters and bicyclic sesquiterpenoids from Dittrichia viscosa. Journal of Natural Products, 55, 1074–1079.
12.
CamachoA, FernandezA, FernandezC, AltarejosJ, LaurentR. (2000) Composition of the essential oil of Dittrichia viscosa. Rivista Italiana EPPOS, 29, 3–8.
13.
MarongiuB, PirasA, PaniF, PorceddaS, BalleroM. (2003) Extraction, separation and, isolation of essential oils from natural matrices by supercritical CO2. Flavour and Fragrance Journal, 18, 505–509
14.
ChiarloB. (1968) Constituents of Inula viscosa. I. Azulene content of the essential oil. Bolletino Chimico Farmaceutico, 107, 370–382.
15.
CumG, SpadaroA, GalloR, RossittoM. (2001) Inula viscosa (L.) Aiton. Parte I: Un secolo di ricerche chimiche. Essenze Derivati Agrumari, 71, 151–170.
16.
ShtacherG, KashmanY. (1970) 12-Carboxyeudesma-3,11(13)-diene. A novel sesquiterpenic acid with a narrow antifungal spectrum. Journal of Medicinal Chemistry, 13, 1221–1223
17.
SusplugasC, BalansardG, JulienJ, GasquetM, Timon-DavidP, RossiJC. (1980) Evidence of anthelmintic action of aerial parts from Inula viscosa Ait. Attribution to a sesquiterpenic acid of this activity. Herba Hungarica, 19, 19–33
18.
AzoulayP, ReynierJP, BalansardG, GasquetM, Timon-DavidP. (1986) Biogalenic and pharmacological study on three sesquiterpenes with antiparasitic actions: helenin, santonin, and 12-carboxy-3,11(13)-eudesmadiene. Pharmaceutica Acta Helvetiae, 61, 345–352.
19.
BarbettiP, ChiappiniI, FardellaG, MenghiniA. (1985) A new eudesmane acid from Dittrichia (Inula) viscosa. Planta Medica, 51, 471
RustaiyanA, JakupovicJ, Chau-ThiTV, BohlmannF, SadjadiA. (1987) Further sesquiterpene lactones from genus Dittrichia. Phytochemistry, 26, 2603–2606
23.
ZargaMHA, HamedEM, SabriSS, VoelterW, ZellerKP. (1998) New sesquiterpenoids from the Jordanian medicinal plant Inula viscosa. Journal of Natural Products, 61, 798–800
24.
ZargaMHA, SabriSS, HamedEM, KhanfarMA, ZellerKP, Atta-ur-Rahman. (2003) A new eudesmane type sesquiterpene from Inula viscosa. Natural Products Research, 17, 99–102.
25.
FontanaG, La RoccaS, PassannantiS, PaternostroMP. (2007) Sesquiterpene compounds from Inula viscosa. Natural Products Research, 21, 824–827.
26.
BohlmannF, CzersonH, SchoeneweissS. (1977) Naturally occurring terpene derivatives, 83. New constituents of Inula viscosa Ait. Chemische Berichte, 110, 1330–1334
27.
DaniewskiWM, KroszczynskiW, BloszykE, DrozdzB, NawrotJ, RychlewskaU, BudesinskyM, HolubM. (1986) On terpenes. Part CCXCIV. Sesquiterpenoids from Dittrichia viscosa (L.) Greuter. Their structure and deterrent activity. Collection of Czechoslovak Chemical Communications, 51, 1710–1721.
28.
MaozM, KashmanY, NeemanI. (1999) Isolation and identification of a new antifungal sesquiterpene lactone from Inula viscosa. Planta Medica, 65, 281–282.
29.
CeccherelliP, CuriniM, MarcotullioMC, MenghiniA. (1988) Structure of cyperanic acid, a new sesquiterpene from Dittrichia viscosa. Journal of Natural Products, 51, 1006–1009.
BenayacheS, BenayacheF, DendouguiH, JayM. (1991) Flavonoids from Inula viscosa L. Plantes Medicinales et Phytotherapie, 25, 170–176.
39.
Alarcon de la LastraC, MartinMJ, DelgadoF, MarhuendaE, MenendezM. (1988) Isolation of caffeic and chlorogenic acids and orcinol from Dittrichia viscosa (L.)GreuterW.Antimicrobial activity. Plantes Medicinales et Phytotherapie, 22, 11–16
40.
ChiarloB, TrevisaniI, AmbrosettiP. (1972) Constituents of Inula viscosa. 3. Total acid content of the essential oil and amino acid and sugar contents of the leaves. Relata Technica di Chimica e Biologia Applicata, 4, 369–374
41.
MañezS, RecioMC, GilI, GomezC, GinerRM, WatermanPG, RiosJL. (1999) A glycosyl analogue of diacylglycerol and other anti-inflammatory constituents from Inula viscosa. Journal of Natural Products, 62, 601–604.
42.
FinkelsteinU. (2005) Novel Inula viscosa extracts and their use for treatment of arthritis. PCT Int. Appl., 37 pp. WO 2005117925 A1 20051215.
43.
HernandezV, RecioMC, MañezS, PrietoJM, GinerRM, RiosJL. (2001) A mechanistic approach to the in vivo anti-inflammatory activity of sesquiterpenoid compounds isolated from Inula viscosa. Planta Medica, 67, 726–731.
44.
MañezS, HernandezV, GinerRM, RiosJL, RecioMC. (2007) Inhibition of pro-inflammatory enzymes by inuviscolide, a sesquiterpene lactone from Inula viscosa. Fitoterapia, 78, 329–331.
45.
HernandezV, MañezS, RecioMC, GinerRM, RiosJL. (2005) Anti-inflammatory profile of dehydrocostic acid, a novel sesquiterpene acid with a pharmacophoric conjugated diene. European Journal of Pharmaceutical Sciences, 26, 162–169.
46.
HernandezV, RecioMC, MañezS, GinerRM, RiosJL. (2007) Effects of naturally occurring dihydroflavonols from Inula viscosa on inflammation and enzymes involved in the arachidonic acid metabolism. Life Sciences, 81, 480–488.
YegenO, BergerB, HeitefussR. (1992) The fungitoxicity of extracts of six selected plants from Turkey against phytopathogenic fungi. Zeitschrift fuer Pflanzenkrankheiten und Pflanzenschutz, 99, 349–359.
49.
Abou-JawdahY, SobhH, SalamehA. (2002) Antimycotic activities of selected plant flora, growing wild in Lebanon, against phytopathogenic fungi. Journal of Agricultural and Food Chemistry, 50, 3208–3213.
50.
VirrusoC. (2003) Infusion of Inula viscosa having properties against hematophage insects, mosquitos flies, horseflies. PCT Int. Appl, WO 2003017768 A2 20030306.
51.
Alarcon de la LastraC, LopezA, MotilvaV. (1993) Gastroprotection and prostaglandin E2 generation in rats by flavonoids of Dittrichia viscosa. Planta Medica, 59, 497–501
52.
MartinMJ, Alarcon de la LastraC, MarhuendaE, DelgadoF, TorreblancaJ. (1988) Anti-ulcerogenicity of the flavonoid fraction from Dittrichia viscosa (L.) W. Greuter in rats. Phytotherapy Research, 2, 183–186.
53.
AbadMJ, GuerraJA, BermejoP, IrurzunA, CarrascoL. (2000) Search for antiviral activity in higher plant extracts. Phytotherapy Research, 14, 604–607.
54.
BedoyaLM, Sanchez PalominoM, AbadMJ, BermejoP, AlcamiJ. (2002) Screening of selected plant extracts for in vitro inhibitory activity on human immunodeficiency virus. Phytotherapy Research, 16, 550–554.
55.
ShalabySIA, AllahEMAH. (2002) Herbal composition and treatment methods/Herbal composition useful for treating viral infection with hepatitis B virus or hepatitis C virus s. US. Pat. Appl. Publ., 14 pp. 2002160065 A1 20021031.
56.
AbdallaS, Abu-ZargaM, AfifiF, Al-KhalilS, SabriS. (1988) Effects of hispidulin, a flavone isolated from Inula viscosa, on isolated guinea pig smooth muscle. General Pharmacology, 19, 559–563.