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Abstract

Carapa procera DC (C. procera), Trichilia monadelpha (Thonn.) J.J.de Wilde (T. monadelpha), Spathodea campanulata P.Beauv (S. campanulata) and Gymnosporia senegalensis Loes (G. senegalensis) are medicinal plants which are used folklorically in Ghana, West Africa, for the treatment and management of diseases. However, there is little scientific evidence and documentation regarding their ethnobotanical uses, phytochemical constituents and pharmacology activities. The objective of this study was to provide a comprehensive literature synthesis of the ethnobotanical uses, phytochemical composition and pharmacological significance of C. procera, G. senegalensis, T. monadelpha and S. campanulata for future research and health benefits. Databases utilized in the literature search included PubMed, Web of Science, Scopus, Google Scholar, PubChem and DrugBank. All plant names were checked with “World Flora Online” (www.worldfloraonline.org). Pharmacological studies conducted in majority of cases indicated anti-inflammatory, anti-oxidant or antimicrobial activities of C. procera, T. monadelpha, S. campanulata and G. senegalensis. Phytochemical analysis also revealed botanical constituents that may potentially be involved in the observed pharmacological properties. This review will go a long way to promote the efficacious use of these plants. However, much remains to be done with respect to preclinical and clinical investigations in order to harness their full potential.

Keywords

phytochemistry pharmacology

Introduction

While some traditional medicinal systems are backed by extensive literature and documented theoretical concepts, others are preserved through oral traditions passed down through generations. Even today, in some regions, a significant portion of the population relies on their traditional medicine for primary health care. The most widely practiced traditional medicinal systems today include those from China, India, and Africa.¹

The African healthcare system essentially consists of a traditional, complementary and alternative medicine aside the mainstream healthcare system. Traditional medicine has thrived on folklore and then ethnopharmacology to fundamentally deliver comparable healthcare to many people around the world. Herbal medicine is the backbone of traditional medicine in Ghana and other sub-Saharan African countries. The beliefs built around it over the decades form the framework that guides the usage of several other medicinal plants in contemporary African primary healthcare settings. Since the past 250 decades, medicinal plants continue to provide a strong basis for traditional medicine with their therapeutic significance, as evident in Chinese and Ayurvedic medicine and other related medicinal practices on the eastern continent.²

In recent times, it can be argued that traditional medicine is fast growing because more than 80% of the people living in developing countries resort to medicinal plants for their primary healthcare,² even though there are inadequate scientific documentations on some of these plants. Patients in Africa frequently use both traditional and modern healthcare, either simultaneously or alternatively, based on their health needs, beliefs, and access to care. This reflects the need for collaboration between healers and healthcare professionals to address diverse health needs.³

Studies show that medicinal plants contain varied phytochemicals which are responsible for their activities and hence serve as a repertoire of bioactive molecules which also serve as precursors for the development of new drug candidates or possible templates of synthetic pharmaceutical products.⁴ For instance, morphine, artemisinin, paclitaxel, and calanolide A are key examples of several plant-derived compounds that have served as drug precursors, used to treat conditions ranging from pain and malaria to cancer and HIV.⁵

Primary and secondary metabolites of plants are largely responsible for their medicinal properties, with the latter largely involved in critical pharmacological roles. These pharmacological properties of plants include antidiabetic, antibacterial, anti-inflammatory, antiparasitic, antiviral, antitumor, antihelmitic and antinociceptive effects. Though secondary metabolites from plants are structurally and functionally diverse, most of them also serve as protective barriers against pathogens, attractants for pollinators and seed-dispersing animals, UV protectants and allelopathic agents.^6,7 They are also employed for the production of dyes, waxes, flowering agents, drugs and perfumes.^6,7

Carapa procera DC (C. procera), Trichilia monadelpha (Thonn.) J.J.de Wilde (T. monadelpha), Spathodea campanulata P. Beauv (S. campanulata) and Gymnosporia senegalensis Loes (G. senegalensis) are some medicinal plants that are used in treatment of various ailments. These plants have been combined and formulated into a product (Dyspepsia) as a remedy for heartburns and nausea in the West African country of Ghana.⁸ The product is generally used in combination with other herbal products for the treatment of peptic ulcer. However, little is known about the bioactive components responsible for their medicinal values. Moreover, the scanty pharmacological reports of their bioactive compounds tend to inhibit their potential applications in drug discovery and development.

The aim of the present literature synthesis was to provide a thorough and scientific documentation of the ethnobotanical uses, phytochemical characteristics and pharmacological significance of these C. procera, T. monadelpha, S. campanulata and G. senegalensis, for future research and health benefits. Overall, ethnobotanical and pharmacological investigations suggested their significant medicinal properties while phytochemical analysis revealed botanical constituents that may potentially be involved in the observed pharmacological properties.

Methodology

This review was based on a thorough literature synthesis of the phytochemical, pharmacological and medicinal properties of C. procera, G. senegalensis, T. monadelpha and S. campanulata. The literature review was conducted using comprehensive databases such as Web of Science, PubMed, PubChem, DrugBank, Scopus and Google Scholar. A total of 123 articles spanning 1961-2024 that provide scientific information on the ethnobotany, phytochemistry and pharmacology of the plant species were considered in the search. Data analysis was qualitative and descriptive. All plant names were checked with “World Flora Online” (www.worldfloraonline.org).

C. procera

General Description

C. procera is a large tropical species that belongs to the Meliaceae family (Figure 1). It is widely distributed across the Central and Southern portions of America and predominantly found in various parts of Africa. It is an oleaginous plant and so reproduces mainly through seeds and grows to a height of 30 m.^9,10 The stem bark is pale brown or gray and smooth with vertical fissures which can peel off in flakes. It has wide-spreading and elliptic to elongate-oblong branches, rounded or wedge-shaped leaves which are mostly clustered at the end of the twigs.¹¹ The leaves are pinnated, averagely ranges from 7 to 17 leaflets in a cluster and measures up to 50 cm long. C. procera produces small whitish to pinkish flowers and the followed by a large, round, woody fruits with a diameter of about 10 cm containing 16 seeds. The evergreen tree is usually found around low-lying areas with swampy conditions and around water bodies, which aids in dispersal of the seeds as a means of propagation.¹² The African mahogany is a native to the tropical Africa and so are known by different names in different countries in Africa. In West Africa, it is referred to as “Akyekyede3” in the Twi language, “Tubaa” in the Dagbani language, and “Kunkum” in the Ewe language in Ghana.¹³ Nigerians call it “Madun-gulu” in the Hausa language, “Akawo” in the Yoruba language, and “Omo” in the Igbo language.¹⁴ In Cote d'Ivoire, C. procera is called “Niam” in the Dioula language and “Nam” in the Bete language.¹⁵ Carapa is also found in Surinam, where it is locally known as “karaba” or “krapa”; in French Guiana, it is referred to as “carapa”; and in the northern Brazilian Amazon, it is called “andiroba”. In these regions, C. procera is often mistaken for C. guianensis.¹⁶

Figure 1.

Pictures of C. procera depicting young leaves, old leaves, stem, fruit, inflorescence and the whole plant.

Traditional Uses

The plant has a long history of use in Africa. The various parts are used for different purposes. The bark is commonly used for the treatment of body pains, chest pains, sore eyes, iritis, conjunctivitis and other diseases in traditional medicine in Africa.¹⁷ It is also used to treat skin conditions and serve as a general tonic.¹⁵ C. procera seed oil is utilized in a variety of products within the cosmetic and pharmaceutical industries and is also employed in biological agriculture for pest control.¹⁸ In Ghana, the dried leaves are used in the treatment of hypertension, while the stem and bark are effective remedy against tuberculosis, anemia, syphilis and trachoma.¹⁹

The oil from the seeds is topically used as an effective remedy against skin conditions such as eczema and psoriasis.¹³ The leaves are used as poultice for the treatment of wounds, to relieve fever and as a general tonic. Economically the plant is used for making soap, candles and insecticides. The wood of C. procera is durable and so it is used in making furniture and musical instruments and also used in the construction industry.¹⁴

The fruit is edible, with seeds producing oil and is regarded as a multipurpose crop (oilwood).²⁰ Fats and oils extracted from the plant is used for the maintenance of healthy skin and hair, as a remedy for sores, burns, rheumatic pains, insect bites, jiggers, eruptions, ringworm, and yaws.¹¹ The Nigerians bath with a decoction from the stem bark of C. procera as an anti-aging regimen.²¹

Phytochemistry

Phytochemical screening of the hydro-methanolic extract showed the presence of steroidal glycosides, triterpene, flavonoids, tannins, leucoanthocyanins and alkaloids while a dichloromethane extract contained triterpene esters and steroid, carotenoids and fatty acid.²² Ethanolic stem bark extract of C. procera contains polyphenols and flavonoids.²³ The oil extracted from C. procera is shown to contain terpenoids, sterols, flavonoids and alkaloids.²⁴ C. procera has been reported to contain a vast array of lipids such as palmitic and oleic acids.²⁰ A methylene chloride/methanol stem bark extract yielded β-sitosterol (1), stigmasterol (2), 3-oxo-21β-H-hop-22(29)-ene (3), 3β-hydroxy-21β-H-hop-22(29)-ene (4), obacunone (5), carapolide I (6), carapolide H (7), and 7β-obacunol (8) (Figure 2).²⁵ Chemical screening of methanolic, ethyl acetate and dichloromethane extracts from the stem bark of C. procera revealed the presence of anthocyanins and organic acids.²⁶ Iwu¹¹ reported the presence of fats, triterpenes and an astringent substance, Tulu kinin. Anthocyanins (cyanidin-3-O-glucoside (9) and cyanidin-3-O-rutinoside (10)), flavonols (quercetin-3-O-rutinoside (11), quercetin-3-O-galactoside (12), quercetin-3-O-glucoside (13), kaempferol rutinoside (14)) and phenolic acids (protocatechuic acid (15), caffeoylquinic acid (16), coumaroylquinic acid (17)) have been identified in the leaves (Figure 2).²⁷ Isolated compounds from the seed include evodulone (18), α-obacunyl acetate (19), methyl angolensate (20) and a Iimonoid proceranone (21).²⁸ Carapolide A (22), a hexanortriterpenoid, and carapolides B (23) and C (24), tetranortriterpenoids have been reported to be present in the seed of Carapa while spirolactone (25) and procerin (26), a tetranortriterpenoid have been reported in the stem bark (Figure 2).²⁹

Figure 2.

Chemical structures of some compounds isolated from C. procera.

Pharmacological Properties

Anthocyanins and organic acids extracted from the stem bark of C. procera exhibited in vitro anti-sickling and antioxidant activities as reported by Ngbolua et al.²⁶ Extracts from the seeds exhibited in vivo cytotoxicity and in vitro estrogenic and anti-androgenic properties in a study by Bayala et al.²² The in vitro antioxidant activity and antifungal activities have also been reported.²⁴ Ethanolic stem bark extract exhibited in vivo antimalarial and antioxidant activities.²³ Additionally, the in vitro antioxidant activity of the stem bark of C. procera has also been reported.²⁶ The antioxidant property is attributed to the higher levels of polyphenols and flavonoids present in the ethanolic extract of the stem bark.²³ In another study, C. procera leaves was shown to have remarkable wound healing property and antibacterial activity against E. coli and S. aureus.³⁰ Titanji et al³¹ reported that a combo of carapolide A and mexicanolide-methylangolensate derived from C. procera are anti-microfilaricidal with stronger bioactivity after 24 h of incubation.

G. senegalensis

General Description

G. senegalensis is commonly referred to as the Senegal thorn or Senegal prickly leaf which belongs to the family Celastraceae (Figure 3). It is a shrub or tree commonly found across most African nations, as well as in regions of Arabia, Afghanistan, and India.^32,33 It grows up to a height of 5-8 meters with a display of a dense and thorny crown. The leaves are oblong, alternate, and glossy green on the surface with a pale underside and occur in groups as an impenetrable bush.³⁴ Flowers are sweetly scented, occurring in dense axillary and terminal clusters. The fruit is a two-lobed capsule, turning pinkish to reddish-brown upon ripening.³⁵

Figure 3.

Pictures of G. senegalensis detailing the leaf shape and color.

Traditional Use

G. senegalensis has reportedly been used in traditional medicine for the treatment of various ailments in both humans and animals. West Africans administer a decoction of the leaves to their livestock for treatment of helminth infestation.^36,37 In Mali, it is used for the treatment of dysmenorrhea³⁸ while in Tanzania³⁹ and Cameroon⁴⁰ extracts of it are used for the treatment of malaria. It is also used as an astringent to treat toothache, stomach-ache and typhoid⁴⁰ and as a treatment for opportunistic infections among people living with HIV/AIDS.⁴¹

Phytochemistry

Isolation of compounds from the leaves revealed the presence of mayselignoside (27), a benzoyl malic acid derivative, benzoyl R-(+)-malic acid (28), two lignan derivatives (+)-lyoniresinol (29) and (−)-isolariciresinol (30), a neolignan derivative dihydrodehydrodiconiferyl alcohol (31) and the triterpenoid, β-amyrin (32) (Figure 4).⁴² Chloroform and hexane root extracts were shown to contain maytenoic acid (33), lupenone (34), β-sitosterol (1) and β-amyrin (32).⁴³ In another investigation, the hydroethanolic leaf extract was shown to contain flavonoids, tannins, saponins, carbohydrates and reducing compounds.⁴⁴ Ethanolic leaf extracts were also reported to contain glycosides, flavonoids, saponins, alkaloids and resins.⁴⁵ Hussein et al⁴⁶ isolated (−)-4’–methylepigallocatechin (35a), (−)-4’-methylepigallocatechin 5-O-β glucopyranoside (36), (−)-epigallocatechin (37), (+)-4’-methylgallocatechin 3’-O-β-glucopyranoside (38), epicatechin (4β → 8) epigallocatechin (39), (−)-epicatechin (4β→8)-(−)-40–methylepigallocatechin (40) and epicatechin (4β→8) epicatechin (procyanidin B-2) (41) and phloroglucinol 1-O-β-D-glucopyranoside (42), from the stem bark using MeOH (Figure 4). Compound (40) can also produce (35a) and (35b) on thiolytic degradation using benzylmercaptan and acetic acid.

Figure 4.

Chemical structures of some compounds isolated from G. senegalensis.

A methanolic leaf extract yielded the following 18 compounds: two novel compounds (2S)-1-O-(4′Z,7′Z,10′Z-octadecatrienoyl) glycerol (43) and (2R)-methyl [(6′-O-alloyl)-β-D-glucopyranosyloxy] phenylacetate (44); and sixteen known compounds (S)-6′-O-galloylsambunigrin (45), (R)-6′-O-galloylprunasin (46), obtained as 1:2 isomeric mixture with 45, 1-O-β-D-(6′-O-galloyl)-glucopyranosyl-3-methoxy-5-hydroxybenzene (47), 3,5-dimethylgallate (48), quercetin (49), kaempferol 3-O-α-L-arabinofuranoside (50), quercetin 3-O-α-L-arabinofuranoside (51), kaempferol 3-O-α-L-rhamnopyranoside (52), quercetin 7-O-α-L-rhamnopyranoside (53), quercetin 3-O-β-D-xylopyranoside (54), quercetin-3-O-(6''-galloyl)-β-D-glucopyranoside (55), epicatechin 3-O-gallate (56), epigallocatechin-3-O-gallate (57), 1:1 isomeric mixture of hesperetin 3′-O-β-D-glucopyranoside (58), β-sitosterol (1), and β-sitosterol glucoside (59) (Figure 4).⁴⁰ Isolation of the chloroform extract of the root bark of G. senegalensis revealed the presence of a quinonemethide triterpene, (20α)-3-hydroxy-2-oxo-24-nor-friedela-1(10),3,5,7-tetraen-carboxylicacid-(29)-methylester (pristimerin) (60).⁴⁷

Pharmacological Properties

Extracts of G. senegalensis have been demonstrated to exhibit anti-plasmodial activity both in vitro^48,49 and in vivo.^39,50 The phenolic content of the methanolic and aqueous stem bark extracts were shown to inhibit HIV-1 protease.⁴⁶ Apart from that, maytenoic acid found in G. senegalensis has been shown to be a suppressor of inflammation,⁴³ a potential mechanism of action against ulcer. Haule et al⁵¹ demonstrated the anti-ulcerogenic activity of a polyherbal mixture containing G. senegalensis in ethanol-HCl induced ulcer in Sprague Dawley rats and further showed its antibacterial activity. This finding about the broad spectrum anti-microbial activity of G. senegalensis could be attributed to the presence of maytenoic acid.^52,53 Apart from that, in vitro inhibition of Mycobacterium tuberculosis, nitric oxide production and tumor necrosis factor-α in a mouse macrophage cell line as well as enhanced radical scavenging potential has been demonstrated.⁵⁴

T. monadelpha

General Description

T. monadelpha (Meliaceae) is an evergreen, semi-deciduous tree of lowland high-forest, usually found on river-banks (Figure 5).⁵⁵ It is erect and cylindrical, with an open, huge spreading evergreen crown. It grows to a height of 12 to 20 m and up to 0.4 m in girth⁵⁶ with a brown bark, green leaves with 4-10 pairs of leaflets and greenish yellow flowers with obovate fruits.⁵⁷ The tree is usually found in humid, tropical conditions. It is indigenous to the West African countries of Sierra Leonne, Ghana, Congo, Benin and Nigeria.⁵⁸

Figure 5.

Pictures of whole plant of T. monadelpha, a close view of the old leaves, stem and young leaves.

Traditional Use

Various parts have been used in traditional for ameliorating different debilitating conditions. For instance, the Nigerians, reportedly soak the bark in water and drink it for the treatment of malaria.⁵⁹ In Brong Ahafo region of Ghana, the stem bark is made into an enema for waist pains or ground and inserted into the vagina for the treatment of candidiasis.⁶⁰ It is also used in Cameroonian folk medicine for the treatment of various diseases such as abdominal pain, dermatitis, hemorrhoids, jaundice, gonorrhea, syphilis and skin inflammation.

Phytochemistry

Phytochemical screening of the hydroethanolic extract of the stem bark revealed the presence of alkaloids, flavonoids, sterols, tannins, and terpenoids (Figure 6). The ethyl acetate extract contains alkaloids, glycosides, tannins, sterols, and terpenoids while petroleum ether extract also contain alkaloids, sterols, and terpenoids.⁶¹ Phytochemical screening of extracts of petroleum ether, ethanol and ethyl acetate of T. monadelpha revealed the presence of alkaloids, terpenoids, phytosterols, reducing sugars, coumarins, tannins, flavonoids, cardiac glycosides, anthraquinones, and saponins.⁶² In another study, Nangmo et al⁶³ isolated from the leaves and root bark of T. monadelpha novel compounds monadelphin A (61) and monadelphin B (62) and sesquiterpenes trichins A (63) and trichin B (64) in addition to the already known six compounds stigmasterol (2), β-sitosterol (1), ellagic acid (65), protocatechuic acid (15), coixol (66) and scopoletin (67). Essential oils derived from the leaf was shown to contain β-Caryophyllene (68) as the major compound, 1-Aminomethyl cyclododecanol (69), cyclohexadecane (70), α-cubebene (71), 1,1,4,8-tetramethyl-4,7,10-cycloundecatriene (72), isopropyl ester (73), cycloeicosane (74), (Z,Z)-2,6-Farnesol (75), 1-(1,5-Dimethylhexyl)-4-(4-methylpentyl) cyclohexane (76), squalene (77) and octadecyl ester (78) (Figure 6).⁶⁴

Figure 6.

Chemical structures of some compounds isolated from T. monadelpha.

Pharmacological Properties

The petroleum ether, ethyl acetate, and hydroethanolic extracts demonstrated anti-depressant effect in murine models.⁶¹ Ben et al⁶² demonstrated the in vitro antioxidant properties. Methanolic extract of the stem bark of T. monadelpha is known to ameliorate oxidative stress and inflammation in colitic rats.⁶⁵ Petroleum ether, ethyl acetate and ethanol extracts of the stem bark of T. monadelpha was showed to be ameliorative in arthritic Sprague-Dawley rats.⁶⁶ The anti-anaphylactic and anti-inflammatory property on rodent models was also demonstrated.⁶⁷ Monadelphin A isolated by Nangmo et al⁶³ was shown to have cytotoxic activity on mouse lymphoma L5178Y cell line with an IC₅₀ value of 0.62 μg/mL.

Anti-inflammatory activity of aqueous, alcoholic and petroleum ether extract of T. monadelpha has been demonstrated in using the 7-day old chicks.⁶⁸ Apart from that, the anti-inflammatory properties of petroleum ether, ethyl acetate and ethanol extracts of the stem bark of T. monadelpha was also shown in Sprague-Dawley rats.⁶⁶ Abiodun et al⁶⁵ also provided evidence that aqueous-methanol extract of stem bark of T. monadelpha have anti-inflammatory activity in trinitrobenzene sulfonic acid-induced colitis. Apart from that, Abiodun et al⁶⁵ showed that T. monadelpha has anti-oxidant property in colitic rats, which explains its use as a remedy for oxygen stress induced inflammatory conditions such as colitis. In another study, the crude aqueous bark extract had shown to be effective in suppressing Plasmodium berghei in mice.⁶⁹

S. campanulata

General Description

S. campanulata (Bignoniaceae) of the Bignoniaceae family also called African tulip occurs as a medium-sized tree in various African counties such as Ghana, Nigeria, Gabon, Cameroon and Senegal (Figure 7).⁷⁰ It has thick branches, large oppositely arranged leaves of up to 50 cm long and reddish-orange-colored flowers.⁷¹

Figure 7.

Pictures of S. campanulata detailing whole plant, flower, old and young leaves.

Ethnobotanical Uses

In traditional medicine, the Ashanti people of Ghana use the stem bark for the treatment of wounds.⁷⁰ It has also been reported to be used for convulsion and epilepsy which was confirmed using ethanolic leaf extracts with electroshock-induced convulsion models in mice.⁷² In some parts of Southwestern Nigeria, the root and stem bark are used traditionally for ameliorating gastric ulcer.⁷³ In the West African states of Ghana, Ivory Coast and Benin, the leaves, root and stem bark of S.campanulata is reportedly used in traditional medicine for the treatment of buruli ulcer, relief for skin conditions, swollen cheeks and body rashes.⁷⁴ S. campanulata has also been used traditionally for the treatment of kidney and urinary system disorders, skin and the gastrointestinal tract related infections.⁷⁵ Apart from medicinal purposes, the bark of Spathodea also provided dye which is used for various traditional purposes.⁷⁶

Phytochemistry

Phytochemical screening of ethanolic leaf extract of S. campanulata showed the presence of tannins, saponins, anthraquinone glycosides, and flavonoids (Figure 8).⁷⁷ An anticonvulsant glycoside, urs-12-en-27α,30-dioic acid 3-O-α-L-rhamnopyranosyl (1→2)-α-L-arabinopyranoside (79) was isolated from the ethanolic leaf extract (Figure 8).⁷² Investigation of ethanolic leaf extract of S. campanulata revealed the presence of polyphenolics, saponins, flavonoids and alkaloids.⁷⁸ Compounds isolated from various parts of Spathodea included verminoside (80), specioside (81), kaempferol 3-O-β-D-(2-O-β-D-glucopyranosyl) glucopyranoside (82) and caffeic acid (83) with antioxidant potential demonstrated against DPPH (Figure 8).⁷⁹ In addition to that, Elusiyan et al⁷⁹ also isolated ajugol (84) (stem bark and fruits) and phytol (85) (leaf). In another analysis, isolation of chloroform leaf extract of S.campanulata yielded stigmasta-5,22-dien-3-ol (86), octadecenamide (87), and umbelliferone (88) all with in vitro cytotoxic activity against human leukemia cancer cell lines (Figure 8).⁸⁰

Figure 8.

Chemical compounds isolated from S. campanulata.

Pharmacology

Methanol leaf extracts of S. campanulata exhibited anti-inflammatory activity against carrageenan-induced paw edema with corresponding acute toxicity studies confirming safety.⁸¹ Wound healing effect due to activity against B. subtilis, E. coli, P. aeruginosa and S. aureus of aqueous, ethanol, methanol and petroleum ether Soxhlet extract of the stem bark of Spathodea was evaluated.⁷⁰ Triterpenoids and flavonol kaempferol from the stem bark of Spathodea was shown to inhibit H.pylori.⁷⁵ Extracts from Spathodea was also active in stabilizing red blood cell (RBC) membrane and also showed good binding affinity towards cyclooxygenase-2 in silico.⁸² S. campanulata has both analgesic and anti-inflammatory properties exhibited in a study using cold, thermal and chemical-induced pain models, and carrageenan-induced acute inflammation in rats.⁷⁷ Ethanolic extract of S. campanulata leaves exhibited anti-ulcer activity in aspirin-induced ulcer in rats.⁷⁸ The cerebroside spathoside and nine phytochemicals were identified from the stem bark extract of S. campanulata with the former showing significant antibacterial activity.⁸³ The stem bark of S. campanulata was shown to have activity against Plasmodium berghei in mice.⁸⁴ Amusan et al⁸⁵ attributed the antimalarial activity to three triterpenoids isolated from the stem bark of S. campanulata which they identified as ursolic acid and two of its derivatives tomentosolic acid and 20β- hydroxyursolic acid.

Conclusion and Future Directions

Ethnobotanical investigations have demonstrated the traditional use of C. procera, T. monadelpha, S. campanulata and G. senegalensis in the treatment of several disorders such as hemorrhoids, gonorrhea, syphilis, skin inflammation, buruli ulcer, dysmenorrhea, malaria, typhoid, tuberculosis. Pharmacological studies conducted in majority of cases have shown anti-inflammatory, anti-oxidant and antimicrobial activities (Table 1). Phytochemical analysis has also revealed the botanical constituents that may potentially be involved in the observed pharmacological properties (Table 1). These constituents include alkaloids, flavonoids, saponins, glycosides, saponins, sterols, tannins, polyphenols, terpenoids and several structural variations (Table 1).

Table 1.

Biological Activities of Selected Compounds from C. procera, T. monadelpha, S. campanulata and G. senegalensis.

Compound	Biological activity	Reference
ajugol	anti-inflammatory; antifibrotic	⁸⁶
caffeic acid	antoxidant potential	⁷⁹
caffeoylquinic acid	cytoprotective effect; enhances proliferation of oligodendrocyte precursor cells	^87,88
carapolide	Inhibition of sarcolemmal Na+/H + exchanger (NHE) activity	⁸⁹
coixol	insulin secretory activity	⁹⁰
cyanidin-3-O-glucoside	free-radical-scavenging properties	⁹¹
cyanidin-3-O-rutinoside	free-radical-scavenging properties	⁹¹
dihydrodehydrodiconiferyl alcohol	suppresses monocyte adhesion to endothelial cells	⁹²
ellagic acid	anti-aging; anti-cancer	^93,94
epicatechin 3-O-gallate	cardioprotective effect	⁹⁵
epigallocatechin-3-O-gallate	antiviral	⁹⁶
evodulone	antitobacco mosaic virus; insecticidal activities	^97,98
lupenone	anti-inflammatory	⁹⁹
maytenoic acid	anti-microbial activity; radical scavenging potential; suppressor of inflammation	^43,52–54
methyl angolensate	antiulcer agent; spasmolytic activity	^100,101
obacunone	anti-proliferative and anti-aromatase activity	¹⁰²
octadecenamide	cytotoxic activity	⁸⁰
phytol	suppresses parasitemia and ameliorates anaemia and oxidative brain damage	¹⁰³
protocatechuic acid	postovulatory oocyte ageing; antiviral; antioxidant and anti-inflammatory characteristics	^104–106
quercetin	anti-cancer; antimicrobial activity	^107,108
quercetin-3-O-galactoside	anti-melanogenesis	¹⁰⁹
quercetin-3-O-glucoside	anti-metastatic potential	¹¹⁰
quercetin-3-O-rutinoside	prevents gastrointestinal injury	¹¹¹
scopoletin	anti-inflammatory and anti-tumorigenesis action	¹¹²
specioside	analgesic, antidyspeptic, astringent	¹¹³
spirolactone	aldosterone-blocking activity; diuretic	^114,115
squalene	chemopreventive activity	¹¹⁶
stigmasta-5,22-dien-3-ol	cytotoxic activity	⁸⁰
stigmasterol	anti-nociceptive effect	¹¹⁷
umbelliferone	cytotoxic activity	⁸⁰
verminoside	anti-inflammatory activity	¹¹⁸
α-obacunyl acetate	anti-septic potential	¹¹⁹
β-sitosterol	lipid lowering effect; Immunomodulatory; inhibits inflammation; enhances osteoblastogenic activity	^108,120
β-amyrin	antifungal; suppresses inflammatory response	^99,121
β-caryophyllene	enhances wound healing	¹²²

Even though several investigations have highlighted the medicinal effects of these plants, the exact biochemical pathways and molecular targets of their active compounds remain largely unknown. This gap in understanding makes it hard to grasp the potential of these plants in disease prevention and treatment, or in developing improved therapies.

Moreover, there hasn't been an in-depth study of the toxicological profiles of these plants. Limited information is available regarding the safety of these plants in traditional medicine and potential pharmaceutical uses. The long-term safety of these plants is uncertain without thorough toxicity studies, especially with increased doses or prolonged use, which hinders their broader acceptance in modern healthcare.

Moreover, much remains to be done with respect to preclinical and clinical investigations. These investigations are carried out to evaluate the efficiency and safety of novel medications or therapies. Although traditional medicine often uses these plants, there is a clear lack of comprehensive clinical studies to assess their effectiveness and safety in humans. The absence of proof hinders the transformation of these traditional remedies into proven clinical treatments.

It is essential to conduct targeted research to fully exploit the potential of these plants. Future studies need to work towards understanding their mechanism of action, conducting comprehensive assessments of their toxicity and safety, and completing carefully planned clinical trials to support the medicinal benefits linked to these species.

Footnotes

Author Contribution

ZR: Writing-original draft; PAJ: Writing-original draft; EE: Writing-original draft; AKD: Writing-original draft, Review & Editing; FA: Study-conceived and designed, Writing-original draft, Review & Editing.

Data Availability Statement

All data used or generated from this study are found in the manuscript.

Declaration of Conflicting Interests

The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Funding

The authors received no financial support for the research, authorship, and/or publication of this article.

ORCID iD

Aboagye Kwarteng Dofuor

References

Che

George

Ijinu

Pushpangadan

Andrae-Marobela

. Traditional medicine. In: Pharmacognosy. Academic Press; 2024:11-28.

Ahad Hussain

Greeshma

Karan Chandra

Arif Pasha

. A review on medicinal plants with anti-diabetic activity. Int J Adv Res. 2020;8(3):902-917. doi:10.21474/ijar01/10705

D'Almeida

Gbomor

Osaio-Kamara

Olagunju

Abodunrin

Foláyan

MNO

. A scoping review of the use of traditional medicine for the management of ailments in West Africa. PLoS One. 2024;19(7):e0306594. doi:10.1371/journal.pone.0306594

Alrasheid

. Current perspectives of herbal remedies in modern medicine. Int J Pharm Sci. 2023;3(1):1-2. doi:10.51626/ijps.2023.03.00013a

Elshafie

Camele

Mohamed

. A comprehensive review on the biological, agricultural, and pharmaceutical properties of secondary metabolites based-plant origin. Int J Mol Sci. 2023;24(4):3266. doi:10.3390/ijms24043266

Croteau

Kutchan

Lewis

. Natural products (secondary metabolites). Biochem Mol Biol Plants. 2000;24:1250-1319.

Dewick

. Medicinal Natural Products: A Biosynthetic Approach. 2nd ed. John Wiley & Sons; 2002.

Kumadoh

Archer

Yeboah

, et al. A review on anti-peptic ulcer activities of medicinal plants used in the formulation of Enterica, Dyspepsia and NPK 500 capsules. Heliyon. 2021;7(12):e08465. doi:10.1016/j.heliyon.2021.e08465

Doligez

Joly

. Mating system of Carapa procera (Meliaceae) in the French Guiana tropical forest. Am J Bot. 1997;84(4):461-470. doi:10.2307/2446022

10.

Dembélé

Lykke

Koné

Témé

Kouyaté

. Use-value and importance of socio-cultural knowledge on Carapa procera trees in the Sudanian zone in Mali. J Ethnobiol Ethnomed. 2015;11:14. doi:10.1186/1746-4269-11-14

11.

Iwu

. Catalog of major African medicinal plants. In: Handbook of African Medicinal Plants. CRC Press; 2013. doi:10.1201/b16292-4.

12.

Oteng-Amoako

Andrew

Ossei Agyekumhene

Zürcher

Rogenmoser

. 100 Tropical African Timber Trees from Ghana: Tree Description and Wood Identification with Notes on Distribution, Ecology, Silviculture, Ethnobotany and Wood uses. Forestry Research Institute of Ghana; 2006.

13.

Asase

Akwetey

Achel

. Ethnopharmacological use of herbal remedies for the treatment of malaria in the Dangme West District of Ghana. J Ethnopharmacol. 2010;129(3):367-376.

14.

Edeoga

Okwu

Mbaebie

. Phytochemical constituents of some Nigerian medicinal plants. Afr J Biotechnol. 2005;4(7):685-688.

15.

Zirihi

N'guessan

Etien

Grellier

. Ethnopharmacological study of plants used to treat malaria in traditional medicine by Bete populations of Issia (Côte d'Ivoire). J Pharm Sci Res. 2010;2(4):216-227.

16.

Forget

Jansen

. Hunting increases dispersal limitation in the tree Carapa procera, a nontimber forest product. Conserv Biol. 2007;21(1):106-113.

17.

Addo-Fordjour

Anning

Akanwariwiak

Belford

EJD

Firempong

. Medicinal plants of Ghana. Genet Res Chromosome Eng Crop Improv. 2012;6:221-246.

18.

Lankoande

Ouedraogo

Boussim

Lykke

. Identification of determining traits of seed production in Carapa procera and Pentadesma butyracea, two native oil trees from riparian forests in Burkina Faso, West Africa. Biomass Bioenergy. 2017;102:37-43. doi:10.1016/j.biombioe.2017.04.002

19.

Owusu

Afedzi

AEK

Quansah

. Phytochemical and proximate content of Carapa procera bark and its antimicrobial potential against selected pathogens. PLoS One. 2021;16(12):e0261755. doi:10.1371/journal.pone.0261755

20.

Djenontin

Wotto

Avlessi

Lozano

Sohounhloué

DKC

Pioch

. Composition of Azadirachta indica and Carapa procera (Meliaceae) seed oils and cakes obtained after oil extraction. Ind Crops Prod. 2012;38(1):39-45. doi:10.1016/j.indcrop.2012.01.005

21.

Elufioye

. Ethnomedicinal study and screening of plants used for memory enhancement and antiaging in Sagamu, Nigeria. Eur J Med Plants. 2012;2(3):262-275. doi:10.9734/ejmp/2012/1372

22.

Bayala

Sow

Millogo

Ouattara

. Toxicity, cytotoxicity and biological activities of seeds of Carapa procera (DC), a native oil tree. Int J Biol Chem Sci. 2019;13(1):49-62. doi:10.4314/ijbcs.v13i1.5

23.

Koama

Yerbanga

Meda

NTR

, et al. In vivo antimalarial, antioxidant activities and safety of Carapa procera DC. (Meliaceae). Pak J Biol Sci. 2021;24(5):571-578. doi:10.3923/pjbs.2021.571.578

24.

Kan

SGK

Yapi

Ama

VBI

, et al. Antifungal and antioxidant activities of Carapa procera oil and its physicochemical characteristics. GSC Biol Pharm Sci. 2020;10(2):130-137.

25.

Melong

Carolle

Kengne

, et al. New cytotoxic obacunone-type limonoid and other constituents from the stem bark of Carapa procera DC (Meliaceae). Nat Prod Res. 2022;36(11):2783-22790. doi:10.1080/14786419.2021.1927024

26.

Ngbolua

Bishola

Mpiana

, et al. Ethno-pharmacological survey, in vitro anti-sickling and free radical scavenging activities of medicinal plants used in Kisangani, DR Congo. Nova J Med Biol Sci. 2014;2(2):1-14.

27.

Adjé

Koffi

Koné

, et al. Polyphenol characterization in red beverages of Carapa procera (D.C.) leaf extracts. Beverages. 2019;5(4):68. doi:10.3390/beverages5040068

28.

Sondengam

Kamga

Kimbu

Connolly

. Proceranone, a new tetranortriterpenoid from Carapa procera. Phytochemistry. 1981;20(1):173-174. doi:10.1016/0031-9422(81)85244-2

29.

Kimbu

Ayafor

Sondengam

Connolly

Rycroft

. Carapolide A, a novel hexanortriterpenoid, and carapolides B and C, novel tetranortriterpenoids from the seeds of Carapa procera (Meliaceae). Tetrahedron Lett. 1984;25(15):1613-1616. doi:10.1016/S0040-4039(01)90025-5

30.

Udoumoh

Chinedu

Kennedy

Emmanuel

. Antibacterial and surgical wound healing properties of ethanolic leaf extracts of Swietenia mahogoni and Carapa procera. Asian J Tradit Med. 2011;6(6):272-277.

31.

Titanji

Evehe

Ayafor

Kimbu

. Novel Onchocerca volvulus filaricides from Carapa procera, Polyalthia suaveolens, and Pachypodanthium staudtii. Acta Leiden. 1990;59(1-2):377-382.

32.

Kassimu

Milando

Omolo

, et al. Safety and tolerability of an antimalarial herbal remedy in healthy volunteers: an open-label, single-arm, dose-escalation study on Maytenus senegalensis in Tanzania. Trop Med Infect Dis. 2022;7(12):396. doi:10.3390/tropicalmed7120396

33.

Da Silva

Serrano

Silva

. Maytenus heterophylla and Maytenus senegalensis, two traditional herbal medicines. J Nat Sci Biol Med. 2011;2(1):59-65. doi:10.4103/0976-9668.82320

34.

Zangueu

Olounlade

Ossokomack

, et al. In vitro effects of aqueous extract from Maytenus senegalensis (Lam.) Exell stem bark on egg hatching, larval migration and adult worms of Haemonchus contortus. BMC Vet Res. 2018;14(1):1-11. doi:10.1186/s12917-018-1475-3

35.

Bingham

Willemen

Wursten

Ballings

Hyde

. Flora of Zambia: species information: records of: Gymnosporia senegalensis. Published August 14, 2024. Accessed August 14, 2024. https://www.zambiaflora.com/speciesdata/citations-display.php?species_id=137000

36.

Djoueche

Azebaze

Dongmo

. Investigation on plants used in the ethnoveterinary control of gastrointestinal parasites in Bénoué region, Cameroon. Tropicultura. 2011;29(4):205-211.

37.

Koné

Kamanzi Atindehou

. Ethnobotanical inventory of medicinal plants used in traditional veterinary medicine in Northern Côte d’Ivoire (West Africa). S Afr J Bot. 2008;74(1):76-84. doi:10.1016/j.sajb.2007.08.015

38.

Sanogo

. Plantes médicinales traditionnellement utilisées au Mali pour la dysménorrhée. Afr J Tradit Complement Altern Med. 2011;8(5 SUPPL):90-96. doi:10.4314/ajtcam.v8i5S.4

39.

Malebo

Wiketye

Katani

, et al. In vivo antiplasmodial and toxicological effect of Maytenus senegalensis traditionally used in the treatment of malaria in Tanzania. Malar J. 2015;14(1):1-7. doi:10.1186/s12936-014-0525-y

40.

Tatsimo

JSN

Toume

Nagata

Havyarimana

Fujii

Komatsu

. Monoglycerol ester, galloylglucoside and phenolic derivatives from Gymnosporia senegalensis leaves. Biochem Syst Ecol. 2019;83:33-38. doi:10.1016/j.bse.2018.12.014

41.

Anywar

Kakudidi

Byamukama

Mukonzo

Schubert

Oryem-Origa

. Indigenous traditional knowledge of medicinal plants used by herbalists in treating opportunistic infections among people living with HIV/AIDS in Uganda. J Ethnopharmacol. 2020;246:112205. doi:10.1016/j.jep.2019.112205

42.

Okoye

FBC

Agbo

Nworu

, et al. New neolignan glycoside and an unusual benzoyl malic acid derivative from Maytenus senegalensis leaves. Nat Prod Res. 2015;29(2):109-115.

43.

Sosa

Morelli

Tubaro

Cairoli

Speranza

Manitto

. Anti-inflammatory activity of Maytenus senegalensis root extracts and of maytenoic acid. Phytomedicine. 2007;14(2-3):109-114. doi:10.1016/j.phymed.2005.11.002

44.

Pascaline

Kossi

Afiwa

Kwashie

E-G

Kodjo

Messanvi

. Effect of Maytenus senegalensis roots on OVA-induced airway inflammation in a mouse asthma model. Afr J Pharm Pharmacol. 2019;13(5):49-56. doi:10.5897/ajpp2019.4999

45.

Kafu

Adebisi

. Phytochemical and antibacterial activity of three medicinal plants found in Nasarawa State. Int J Sci Res Publ. 2015;5(1):2250-3153. http://www.ijsrp.org/research-paper-0115.php?rp=P373558

46.

Hussein

Nakamura

Meselhy

Hattori

. Phenolics from Maytenus senegalensis. Phytochemistry. 1999;50(4):689-694. doi:10.1016/S0031-9422(98)00571-8

47.

Khalid

Friedrichsen

Christensen

El Tahir

Satti

. Isolation and characterization of pristimerin as the antiplasmodial and antileishmanial agent of Maytenus senegalensis (Lam.) Exell. Arkivoc. 2007;(ix):129-134. ISSN 1424-6376.

48.

Gessler

Nkunya

MHH

Mwasumbi

Heinrich

Tanner

. Screening Tanzanian medicinal plants for antimalarial activity. Acta Trop. 1994;56(1):65-77. doi:10.1016/0001-706X(94)90041-8

49.

El Tahir

Satti

GMH

Khalid

. Antiplasmodial activity of selected Sudanese medicinal plants with emphasis on Maytenus senegalensis (Lam.) Exell. J Ethnopharmacol. 1999;64(3):227-233. doi:10.1016/S0378-8741(98)00129-9

50.

Jigam

Musa

Abdullahi

Lawal

. Characterization of anti-plasmodial, analgesic and anti-inflammatory fraction of Maytenus senegalensis (Lam.) Exell leaf extract in mice. Clin Phytosci. 2020;6(1):4-11. doi:10.1186/s40816-020-00201-z

51.

Haule

Moshi

Nondo

Mwangomo

Mahunnah

. A study of antimicrobial activity, acute toxicity and cytoprotective effect of a polyherbal extract in a rat ethanol-HCl gastric ulcer model. BMC Res Notes. 2012;5:546. doi:10.1186/1756-0500-5-546

52.

Lindsey

Budesinsky

Kohout

van Staden

. Antibacterial activity of maytenonic acid isolated from the root-bark of Maytenus senegalensis. S Afr J Bot. 2006;72(3):473-477. doi:10.1016/j.sajb.2005.12.011

53.

Matu

Van Staden

. Antibacterial and anti-inflammatory activities of some plants used for medicinal purposes in Kenya. J Ethnopharmacol. 2003;87(1):35-41. doi:10.1016/S0378-8741(03)00107-7

54.

Makgatho

Nxumalo

Raphoko

. Anti-mycobacterial, -oxidative, -proliferative and -inflammatory activities of dichloromethane leaf extracts of Gymnosporia senegalensis (Lam.) Loes. S Afr J Bot. 2018;114:217-222. doi:10.1016/j.sajb.2017.11.002

55.

Fern

. Trichilia monadelpha. Tropical Plants Database; August 23, 2024. http://tropical.theferns.info/viewtropical.php?id=Trichilia+monadelpha

56.

Agyare

Obiri

Boakye

Osafo

. Anti-inflammatory and analgesic activities of African medicinal plants. In: Medicinal Plant Research in Africa: Pharmacology and Chemistry. 2013:725-752. doi:10.1016/B978-0-12-405927-6.00019-9

57.

Busia

. Ghana Herbal Pharmacopoeia. Ghana: Science and Technology Policy Research Institute; 2007:2086-2212.

58.

Irvine

. Woody Plants of Ghana. Oxford University Press; 1961:528.

59.

Olorunniyi

Morenikeji

. The extent of use of herbal medicine in malaria management in Ido/Osi Local Government Area of Ekiti State, Nigeria. J Med Plant Res. 2013;7(42):3171-3178. doi:10.5897/JMPR2013.5101

60.

Addo-Fordjour

Anning

Jeremiah

Belford

. Diversity and conservation of medicinal plants in the Bomaa community of the Brong Ahafo region, Ghana. J Med Plant Res. 2008;2(9):226-233. doi:10.5897/JMPR.9000454

61.

Kukuia

KKE

Mensah

Amoateng

Amponsah

N’Guessan

Asiedu-Gyekye

. Antidepressant potentials of components from Trichilia monadelpha (Thonn.) J.J. de Wilde in murine models. Evid Based Complement Alternat Med. 2018;2018:6863973. doi:10.1155/2018/6863973

62.

Ben

Woode

Abotsi

WKM

Boakye-Gyasi

. Preliminary phytochemical screening and in vitro antioxidant properties of Trichilia monadelpha (Thonn.) JJ De Wilde (Meliaceae). J Med Biomed Sci. 2013;2(2):6-15.

63.

Nangmo

Tsamo

Zhen

, et al. Chemical constituents from leaves and root bark of Trichilia monadelpha (Meliaceae). Phytochem Lett. 2018;23:120-126. doi:10.1016/j.phytol.2017.11.020

64.

Oluwakayode

Onocha

. Antioxidant and antimicrobial activities of β-caryophyllene dominated leaf essential oil of Trichilia monadelpha (Thonn.) J.J. de Wilde. J Nat Sci Res. 2020;11(16):35-42. doi:10.7176/jnsr/11-16-05

65.

Abiodun

Ogunleye

Ben-Upaka

Tijani

. P3 Trichilia monadelpha (TM) Thonn J.J. de Wilde ameliorates oxidative stress and inflammation in TNBS-induced colitis. Biochem Pharmacol. 2017;139:125. doi:10.1016/j.bcp.2017.06.004

66.

Ben

Woode

Koffuor

Boakye-Gyasi

Titiloye

. Effect of Trichilia monadelpha (Meliaceae) extracts on bone histomorphology in complete Freund's adjuvant-induced arthritis. J Intercult Ethnopharmacol. 2017;6(2):177-185. doi:10.5455/jice.20170218092913

67.

Ben

Woode

Koffuor

Asiamah

. Anti-anaphylactic effects of Trichilia monadelpha (Thonn.) J.J. de Wilde extracts on rodent models of anaphylaxis. Res Pharm Sci. 2016;11(5):397-404. doi:10.4103/1735-5362.192491

68.

Ainooson

Owusu

Woode

Ansah

Annan

. Trichilia monadelpha bark extracts inhibit carrageenan-induced foot-oedema in the 7-day old chick and the oedema associated with adjuvant-induced arthritis in rats. Afr J Tradit Complement Altern Med. 2012;9(1):7-17. doi:10.4314/ajtcam.v9i1.2

69.

Olorunniyi

Adewumi

. In vivo antimalarial activity of crude aqueous leaf extract of Pyrenacantha staudtii against Plasmodium berghei (NK65) in infected mice. Afr J Pharm Pharmacol. 2014;8(12):342-345. doi:10.5897/ajpp2013.3950

70.

Ofori-Kwakye

Kwapong

Adu

. Antimicrobial activity of extracts and topical products of the stem bark of Spathodea campanulata for wound healing. Afr J Tradit Complement Altern Med. 2009;6(2):168-174. doi:10.4314/ajtcam.v6i2.57089

71.

Wagh

Butle

. Plant profile, phytochemistry, and pharmacology of Spathodea campanulata P. Beauvais (African tulip tree): a review. Int J Pharm Pharm Sci. 2018;10(5):1-6.

72.

Ilodigwe

Akah

Okoye

Omeje

. Anticonvulsant effects of a glycoside isolated from the leaf of Spathodea campanulata P. Beauv. J Med Plants Res. 2010;4(18):1895-1900. doi:10.5897/JMPR10.360

73.

Akinwumi

Sonibare

. Use of medicinal plants for the treatment of gastric ulcer in some parts of Southwestern Nigeria. Afr J Pharm Pharmacol. 2019;13(15):223-235.

74.

Tsouh Fokou

Nyarko

Appiah-Opong

, et al. Ethnopharmacological reports on anti-Buruli ulcer medicinal plants in three West African countries. J Ethnopharmacol. 2015;172:297-311. doi:10.1016/j.jep.2015.06.024

75.

Ngnameko

Marchetti

Zambelli

, et al. New insights into bioactive compounds from the medicinal plant Spathodea campanulata P. Beauv. And their activity against Helicobacter pylori. Antibiotics. 2020;9(5):258. doi:10.3390/antibiotics9050258

76.

Quashie

Gbadegbe

Buami

Ayitey

Vigbedor

. Experimental procedures of fiber extraction from Spathodea campanulata (African Tulip Tree) for cord. J Arts Humanit. 2021;10(10):1-11. doi:10.18533/jah.v10i10.2181

77.

Ilodigwe

Akah

. Spathodea campanulata: an experimental evaluation of the analgesic and anti-inflammatory properties of a traditional remedy. Asian J Med Sci. 2009;1(2):35-38.

78.

Khatri

Goswami

Jain

. Phytochemical screening and evaluation of antiulcer activity of ethanolic extract of Spathodea campanulata leaves. J Drug Deliv Ther. 2019;9(4-s):1012-1015. doi:10.22270/jddt.v9i4-s.3728

79.

Elusiyan

Ani

Adewunmi

Olugbade

. Distribution of iridoid glucosides and antioxidant compounds in Spathodea campanulata parts. Afr J Tradit Complement Altern Med. 2011;8(1):27-33. doi:10.4314/ajtcam.v8i1.60491

80.

Wagh

Butle

Raut

. Isolation, identification, and cytotoxicity evaluation of phytochemicals from chloroform extract of Spathodea campanulata. Futur J Pharm Sci. 2021;7:58. doi:10.1186/s43094-021-00205-7

81.

Vijayasanthi

Doss

Kannan

. Anti-inflammatory activity of Spathodea campanulata P. Beauv. Leaves against carrageenan-induced paw edema. Elixir Biotechnol. 2015;78:29450-29452. https://www.researchgate.net/publication/276409790

82.

Boniface

Verma

Shukla

Khan

. Membrane stabilization: a possible anti-inflammatory mechanism for the extracts and compounds from Spathodea campanulata. Nat Prod Res. 2014;28(23):2203-2207. doi:10.1080/14786419.2014.930858

83.

Jean

Mbosso

Ngouela

, et al. Spathoside, a cerebroside and other antibacterial constituents of the stem bark of Spathodea campanulata. Nat Prod Res. 2010;22(4):296-304. doi:10.1080/14786410701766281

84.

Makinde

Amusan

Adesogan

. The antimalarial activity of Spathodea campanulata stem bark extract on Plasmodium berghei berghei in mice. Planta Med. 1988;54(2):122-125. doi:10.1055/s-2006-962367

85.

Amusan

OOG

Adesogan

Makinde

. Antimalarial active principles of Spathodea campanulata stem bark. Phytother Res. 1996;10(8):692-693. doi:10.1002/(SICI)1099-1573(199612)10:8<692::AID-PTR928>3.0.CO;2-O

86.

Zhou

Song

, et al. A novel iridoid glycoside leonuride (ajugol) attenuates airway inflammation and remodeling through inhibiting type-2 high cytokine/chemokine activity in OVA-induced asthmatic mice. Phytomedicine. 2022;105:154345. doi:10.1016/j.phymed.2022.154345

87.

Chen

Yang

Cho

, et al. 5-Caffeoylquinic Acid ameliorates oxidative stress-mediated cell death via Nrf2 activation in hepatocytes. Pharm Biol. 2020;58(1):999-1005. doi:10.1080/13880209.2020.1818791

88.

Yanqin

Shaohua

Jing

Nan

. Caffeoylquinic acid enhances proliferation of oligodendrocyte precursor cells. Transl Neurosci. 2017;8:111-116. doi:10.1515/tnsci-2017-0017

89.

Hoshino

Avkiran

. Effects of moderate hypothermia on sarcolemmal Na(+)/H(+) exchanger activity and its inhibition by cariporide in cardiac ventricular myocytes. Br J Pharmacol. 2001;134(7):1587-1595. doi:10.1038/sj.bjp.0704405

90.

Sharma

Adhikari

Hafizur

, et al. Potent insulin secretagogue from Scoparia dulcis Linn of Nepalese origin. Phytother Res. 2015;29(10):1672-1675. doi:10.1002/ptr.5412

91.

Delazar

Khodaie

Afshar

Nahar

Sarker

. Isolation and free-radical-scavenging properties of cyanidin 3-O-glycosides from the fruits of Ribes biebersteinii Berl. Acta Pharm. 2010;60(1):1-11. doi:10.2478/v10007-010-0007-x

92.

Tsuneyoshi

Kanamori

Matsutomo

Morihara

. Dehydrodiconiferyl alcohol suppresses monocyte adhesion to endothelial cells by attenuation of JNK signaling pathway. Biochem Biophys Res Commun. 2015;465(3):408-413. doi:10.1016/j.bbrc.2015.08.020

93.

Zhu

Yan

Jiang

Meng

. Ellagic acid and its anti-aging effects on central nervous system. Int J Mol Sci. 2022;23(18):10937. doi:10.3390/ijms231810937

94.

Mohammadinejad

Mohajeri

Aleyaghoob

Heidarian

Kazemi Oskuee

. Ellagic acid as a potent anticancer drug: a comprehensive review on in vitro, in vivo, in silico, and drug delivery studies. Biotechnol Appl Biochem. 2022;69(6):2323-2356. doi:10.1002/bab.2288

95.

Yang

Jiang

, et al. Epicatechin-3-gallate signaling and protection against cardiac ischemia/reperfusion injury. J Pharmacol Exp Ther. 2019;371(3):663-674. doi:10.1124/jpet.119.260117

96.

Kaihatsu

Yamabe

Ebara

. Antiviral mechanism of action of epigallocatechin-3-O-gallate and its fatty acid esters. Molecules. 2018;23(10):2475. doi:10.3390/molecules23102475

97.

Liu

Zhang

Hao

. The limonoids and their antitobacco mosaic virus (TMV) activities from Munronia unifoliolata Oliv. J Agric Food Chem. 2012;60(17):4289-4295. doi:10.1021/jf205362d

98.

Zhang

Wang

Wei

Y-C

Wang

X-B

Kong

L-Y

. Bioactive terpenoids from the fruits of Aphanamixis grandifolia. J Nat Prod. 2013;76(6):1191-1195. doi:10.1021/np400126q

99.

Yang

Huang

Liang

Wang

. Lupenone is a good anti-inflammatory compound based on the network pharmacology. Mol Divers. 2020;24(1):21-30. doi:10.1007/s11030-019-09928-5

100.

Njar

Adesanwo

Raji

. Methyl angolensate: the antiulcer agent of the stem bark of Entandrophragma angolense. Planta Med. 1995;61(1):91-92. doi:10.1055/s-2006-958015

101.

Orisadipe

Amos

Adesomoju

, et al. Spasmolytic activity of methyl angolensate: a triterpenoid isolated from Entandrophragma angolense. Biol Pharm Bull. 2001;24(4):364-367. doi:10.1248/bpb.24.364

102.

Kim

Jayaprakasha

Patil

. Obacunone exhibits anti-proliferative and anti-aromatase activity in vitro by inhibiting the p38 MAPK signaling pathway in MCF-7 human breast adenocarcinoma cells. Biochimie. 2014;105:36-44. doi:10.1016/j.biochi.2014.06.002

103.

Usman

Abubakar

Salman

Adamu

Ibrahim

. Phytol suppresses parasitemia and ameliorates anaemia and oxidative brain damage in mice infected with Plasmodium berghei. Exp Parasitol. 2021;224:108097. doi:10.1016/j.exppara.2021.108097

104.

Chao

Zhao

, et al. Protocatechuic acid delays postovulatory oocyte ageing in mouse. Mol Nutr Food Res. 2023;67(4). doi:10.1002/mnfr.202200363

105.

Wang

Ren

, et al. Protocatechuic acid protects mice from influenza A virus infection. Eur J Clin Microbiol Infect Dis. 2022;41(4):589-596. doi:10.1007/s10096-022-04401-y

106.

Albarakati

AJA

. Protocatechuic acid counteracts oxidative stress and inflammation in carrageenan-induced paw edema in mice. Environ Sci Pollut Res Int. 2022;29(37):56393-56402. doi:10.1007/s11356-022-19688-9

107.

Reyes-Farias

Carrasco-Pozo

. The anti-cancer effect of quercetin: molecular implications in cancer metabolism. Int J Mol Sci. 2019;20(13):3177. doi:10.3390/ijms20133177

108.

Nguyen

TLA

Bhattacharya

. Antimicrobial activity of quercetin: an approach to its mechanistic principle. Molecules. 2022;27(8):2494. doi:10.3390/molecules27082494

109.

Karadeniz

Seo

Yang

Lee

Kong

. Quercetin 3-O-galactoside isolated from Limonium tetragonum inhibits melanogenesis by regulating PKA/MITF signaling and ERK activation. Int J Mol Sci. 2023;24(4):3064. doi:10.3390/ijms24043064

110.

Lee

Han

Yun

Kim

. Quercetin 3-O-glucoside suppresses epidermal growth factor-induced migration by inhibiting EGFR signaling in pancreatic cancer cells. Tumour Biol. 2015;36(12):9385-9393. doi:10.1007/s13277-015-3682-x

111.

Dutta

Dahiya

. Quercetin 3-O rutinoside prevents gastrointestinal injury through regulation of apoptosis in 7.5 Gy total body irradiated mice. Phytomedicine. 2023;112:154692. doi:10.1016/j.phymed.2023.154692

112.

Sakthivel

Vishnupriya

Priya Dharshini

Rasmi

Ramesh

. Modulation of multiple cellular signalling pathways as targets for anti-inflammatory and anti-tumorigenesis action of scopoletin. J Pharm Pharmacol. 2022;74(2):147-161. doi:10.1093/jpp/rgab047

113.

Asthana

Yadav

Pant

Pandey

Gupta

Pandey

. Specioside ameliorates oxidative stress and promotes longevity in Caenorhabditis elegans. Comp Biochem Physiol C Toxicol Pharmacol. 2015;169:25-34. doi:10.1016/j.cbpc.2015.01.002

114.

Struthers

Krum

Williams

. A comparison of the aldosterone-blocking agents eplerenone and spironolactone. Clin Cardiol. 2008;31(4):153-158. doi:10.1002/clc.20324

115.

Horisberger

Giebisch

. Potassium-sparing diuretics. Ren Physiol. 1987;10(3-4):198-220. doi:10.1159/000173130

116.

Rao

Newmark

Reddy

. Chemopreventive effect of squalene on colon cancer. Carcinogenesis. 1998;19(2):287-290. doi:10.1093/carcin/19.2.287

117.

Walker

CIB

Oliveira

Tonello

, et al. Anti-nociceptive effect of stigmasterol in mouse models of acute and chronic pain. Naunyn Schmiedebergs Arch Pharmacol. 2017;390(11):1163-1172. doi:10.1007/s00210-017-1416-x

118.

Picerno

Autore

Marzocco

Meloni

Sanogo

Aquino

. Anti-inflammatory activity of verminoside from Kigelia africana and evaluation of cutaneous irritation in cell cultures and reconstituted human epidermis. J Nat Prod. 2005;68(11):1610-1614. doi:10.1021/np058046z

119.

Weng

Wang

Zhen

. Anti-septic potential of 7-α-obacunyl acetate isolated from Toona sinensis on cecal ligation/puncture mice via suppression of JAK-STAT/NF-κB signal pathway. Infect Drug Resist. 2021;14:1813-1821. doi:10.2147/IDR.S302853

120.

Yuan

Zhang

Long

Jin

. Effect of β-sitosterol self-microemulsion and β-sitosterol ester with linoleic acid on lipid-lowering in hyperlipidemic mice. Lipids Health Dis. 2019;18(1):157. doi:10.1186/s12944-019-1096-2

121.

Kwun

Lee

. β-amyrin-induced apoptosis in Candida albicans triggered by calcium. Fungal Biol. 2021;125(8):630-636. doi:10.1016/j.funbio.2021.03.006

122.

Koyama

Purk

Kaur

, et al. Beta-caryophyllene enhances wound healing through multiple routes. PLoS One. 2019;14(12):e0216104. doi:10.1371/journal.pone.0216104

Phytochemical,Pharmacological and Medicinal Properties of Carapa procera,Trichilia monadelpha,Spathodea campanulata and Gymnosporia senegalensis

Abstract

Keywords

Introduction

Methodology

C. procera

General Description

Traditional Uses

Phytochemistry

Pharmacological Properties

G. senegalensis

General Description

Traditional Use

Phytochemistry

Pharmacological Properties

T. monadelpha

General Description

Traditional Use

Phytochemistry

Pharmacological Properties

S. campanulata

General Description

Ethnobotanical Uses

Phytochemistry

Pharmacology

Conclusion and Future Directions

Footnotes

Author Contribution

Data Availability Statement

Declaration of Conflicting Interests

Funding

ORCID iD

References