Three diterpenoid dolabellane esters were isolated from Cleome droserifolia. The chemical structures of the isolated compounds were determined by spectral as well as chemical methods. These dolabellanes (I, II and III) are ester derivatives of 3-hydroxy-3-methyl glutaric acid (3-HMGA). Compounds I and II have the second (3HMGA) carboxyl function free, while compound III is the methyl ester of compound I. This is the first report of the isolation of this class of compounds from the genus Cleome and is the first report of the isolation of compound III from a natural source. In addition, eight flavone derivatives were isolated.
TäckholmV. (1974) Student's flora of Egypt, second edition.
2.
YangSS, MabryTJ, El-fishawyAM, El-KashouryEA, Abd ElKawyMA, SolimanFM. (1990) Flavonoids of Cleome droserifolia. Egyptian Journal of Pharmaceutical Sciences, 31, 443–446.
3.
El-ShabrawyOA, NadaSA. (1996) Biological evaluation of multicomponent tea used as hypoglycemic in rats. Fitoterapia, 67, 99–102.
4.
NicolaWG, IbrahimKM, MikhailTH, GirgisRB, KhadrME. (1996) Role of hypoglycemic plant extract Cleome droserifolia in improving glucose and lipid metabolism and its reaction to insulin resistance in fatty liver. Bollettino Chimico Farmaceutica, 135, 507–517, through Medline.
5.
GhanemMM, (1999) M.S. Thesis, Faculty of Medicine, Alexandria University.The short term effect of use of some medicinal plants used in folk medicine on non-insulin- dependent diabetes mellitus (NIDMM) patients (type II diabetes).
6.
DiabLI. (1992) M.S. Thesis, AL-Azhar University. Pharmacognostical study of certain Cleome species growing in Egypt.
El-AskaryH. (2005) Terpenoids from Cleome droserifolia (Forssk.) Del. Molecules, 10, 971–977.
9.
Seif El-DinAA, DarwishFA, AboudoniaAA. (1987) Flavonoids from Cleome droserifolia (Forssk) Del. growing in Egypt. Egyptian Journal of Pharmaceutical Sciences, 28, 313–319.
10.
NassarMI, Gamal-EldeenAH. (2003) Potential antioxidant activity of flavonoids from Hypericum triquetrifolium Turra and Cleome droserifolia (Forssk) Del. Bulletin of the faculty of pharmacy (Cairo University), 41, 107–115.
11.
Abdel-QawiM, El-DibS, El-KhayyatZ, MikkaeilYA. (2000) Chemical and biological studies of Cleome droserifolia: part 1. Egyptian Journal of Biomedical Sciences, V6, 204–218.
SharafM, El-AnsariMA, SalehNAM. (1997) Flavonoids of four Cleome and three Capparis species. Biochemical Systematics and Ecology, 25, 161–166.
14.
SharafM, MansourRMA, SalehNAM. (1992) Exudate flavonoids from aerial parts of four Cleome species, Biochemical Systematics and Ecology, 20, 443–448.
15.
ShinjiF, YojiH, JavzanB, FumihideT, SingabA, ToruO. (1999) Flavonoids from Cleome droserifolia suppress NO production in activated macrophages in vitro. Journal of Natural Products, 65, 404–407.
