1D and 2D NMR spectroscopic techniques were used to obtain the complete characterization of cycloart-23-ene-3β-ol (1), isolated from one of the two species of Senefelderopsis belonging to the Euphorbiaceae family. This is the first report, including the NMR data, of this anti-inflammatory steroid isolated from a plant source.
SuárezAI, BlancoZ., CompagnoneRS, Salazar-BookamanMM, ZapataV, AlvaradoC. (2006) Anti-inflammatory activity of Croton cuneatus aqueous extract. Journal of Ethnopharmacology, 105, 99–101.
2.
SuárezAI, BlancoZ, Delle MonacheF, CompagnoneRS, ArveloF. (2004) Three new glutarimide alkaloids from Croton cuneatus. Natural Product Research, 18, 421–426.
3.
SuárezAI, ManzanoM, VasquezL, CompagnoneRS. (2005) Essential oil composition of Croton cuneatus and Croton malambo growing in Venezuela. Flavour and Fragance Journal, 20, 611–614.
4.
WebsterGL, BerryPE, ArmbrusterWS, EsserHJ, GillespieLJ, HaydenWJ, LevinGA, SeccoR, HealdSV. (1999) Euphorbiaceae. In SteyermankJ, BerryP, YatskievychK, HolstB. (Eds). Flora of the Venezuelan Guayana, Missouri Botanical Garden Press, St. Louis. 224–225.
5.
CanelónDJ, CompagnoneRS, CastilloA, SuárezAI. (2005) Chemical constituents of Senefelderopsis chiribiquetensis. Biochemical Systematics and Ecology, 33, 1303–1306.
6.
LeeSS, YoungLH, WangK. (1992) Separation of 24-methylenecycloartanol from cycloartenol via a chemical method. Journal of Natural Products, 55, 644–648.
7.
KikuchiT, TokudaH, UkiyaM, WatanabeK, NishinoH. (2007) Cancer chemopreventive effects of cycloartane-type and related triterpenoids in vitro and in vivo models. Journal of Natural Products, 70, 918–922.
8.
De PascualJ, UronesT, BasameP, SexmeroMJ, FernándezR. (1987) Triterpenes from Euphorbia brotei. Phytochemistry, 26, 1767–1776.
9.
BanskotaAH, TezukaY, TranKQ, TanakaK, SaikiI, KadotaS. (2000) Thirteen novel cycloartane-type triterpenes from Combretum quadrangulare. Journal of Natural Products, 63, 57–64.
MossmannT. (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. Journal of Immunological Methods, 65, 55–63.
12.
GreenLC, WagnerJA, GlogowskiJ, SkipperPL, WhisnokJS, TannenbaumSR. (1982) Analysis of nitrate, nitrite and 15N nitrate in biological fluids. Analytical Biochemistry, 126, 131–138.
13.
RenierG, SkameneE, De SanctisJB, RadziochD. (1994) Induction of tumor necrosis factor alpha gene expression by lipoprotein lipase. Journal of Lipid Research, 3, 271–278.