Open accessResearch articleFirst published online 2019
RETRACTED: Downregulation of long noncoding RNA LINC01419 inhibits cell migration,invasion,and tumor growth and promotes autophagy via inactivation of the PI3K/Akt1/mTOR pathway in gastric cancer
At the request of the authors and with agreement of the editorial team, the following article has been retracted:
Wang L-L, Zhang L, Cui X-F. Downregulation of long noncoding RNA LINC01419 inhibits cell migration, invasion, and tumor growth and promotes autophagy via inactivation of the PI3K/Akt1/mTOR pathway in gastric cancer. Therapeutic Advances in Medical Oncology. 2019; 11: 1–16 (doi: 10.1177/1758835919874651).
The authors and the editorial team advise that there are concerns around the scientific accuracy and legitimacy of the manuscript.
References
1.
ZhangHFengMFengY, et al. Germline mutations in hereditary diffuse gastric cancer. Chin J Cancer Res2018; 30: 122–130.
2.
WaddellTVerheijMAllumW, et al. Gastric cancer: ESMO-ESSO-ESTRO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol2013; 24(Suppl. 6): vi57–vi63.
3.
LiuXHSunMNieFQ, et al. Lnc RNA HOTAIR functions as a competing endogenous RNA to regulate HER2 expression by sponging miR-331-3p in gastric cancer. Mol Cancer2014; 13: 92.
4.
QuYDangSHouP.Gene methylation in gastric cancer. Clin Chim Acta2013; 424: 53–65.
5.
OhtsuAAjaniJABaiYX, et al. Everolimus for previously treated advanced gastric cancer: results of the randomized, double-blind, phase III GRANITE-1 study. J Clin Oncol2013; 31: 3935–3943.
6.
ShiWHWuQQLiSQ, et al. Upregulation of the long noncoding RNA PCAT-1 correlates with advanced clinical stage and poor prognosis in esophageal squamous carcinoma. Tumour Biol2015; 36: 2501–2507.
7.
RavehEMatoukIJGilonM, et al. The H19 long non-coding RNA in cancer initiation, progression and metastasis - a proposed unifying theory. Mol Cancer2015; 14: 184.
8.
EndoHShirokiTNakagawaT, et al. Enhanced expression of long non-coding RNA HOTAIR is associated with the development of gastric cancer. PLoS One2013; 8: e77070.
9.
SpizzoRAlmeidaMIColombattiA, et al. Long non-coding RNAs and cancer: a new frontier of translational research?Oncogene2012; 31: 4577–4587.
10.
MitraSAMitraAPTricheTJ.A central role for long non-coding RNA in cancer. Front Genet2012; 3: 17.
11.
ZhangHZhuCZhaoY, et al. Long non-coding RNA expression profiles of hepatitis C virus-related dysplasia and hepatocellular carcinoma. Oncotarget2015; 6: 43770–43778.
12.
ChangLLiCLanT, et al. Decreased expression of long non-coding RNA GAS5 indicates a poor prognosis and promotes cell proliferation and invasion in hepatocellular carcinoma by regulating vimentin. Mol Med Rep2016; 13: 1541–1550.
13.
ZhangHYYangWZhengFS, et al. Long non-coding RNA SNHG1 regulates zinc finger E-box binding homeobox 1 expression by interacting with TAp63 and promotes cell metastasis and invasion in Lung squamous cell carcinoma. Biomed Pharmacother2017; 90: 650–658.
ZhaoYGuoQChenJ, et al. Role of long non-coding RNA HULC in cell proliferation, apoptosis and tumor metastasis of gastric cancer: a clinical and in vitro investigation. Oncol Rep2014; 31: 358–364.
16.
DaiMChenSWeiX, et al. Diagnosis, prognosis and bioinformatics analysis of lncRNAs in hepatocellular carcinoma. Oncotarget2017; 8: 95799–95809.
17.
CoutteLDreyerCSablinMP, et al. PI3K-AKT-mTOR pathway and cancer. Bull Cancer2012; 99: 173–180.
18.
TapiaORiquelmeILealP, et al. The PI3K/AKT/mTOR pathway is activated in gastric cancer with potential prognostic and predictive significance. Virchows Arch2014; 465: 25–33.
19.
WangKLiuRLiJ, et al. Quercetin induces protective autophagy in gastric cancer cells: involvement of Akt-mTOR- and hypoxia-induced factor 1alpha-mediated signaling. Autophagy2011; 7: 966–978.
20.
OshimaTMasudaM.Molecular targeted agents for gastric and gastroesophageal junction cancer. Surg Today2012; 42: 313–327.
21.
YuGLiuGYuanD, et al. Long non-coding RNA ANRIL is associated with a poor prognosis of osteosarcoma and promotes tumorigenesis via PI3K/Akt pathway. J Bone Oncol2018; 11: 51–55.
22.
FujitaASatoJRRodrigues LdeO, et al. Evaluating different methods of microarray data normalization. BMC Bioinformatics2006; 7: 469.
23.
RobinsonMDMcCarthyDJSmythGK.edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics2010; 26: 139–140.
24.
YangFBiJXueX, et al. Up-regulated long non-coding RNA H19 contributes to proliferation of gastric cancer cells. FEBS J2012; 279: 3159–3165.
25.
ZhouXYinCDangY, et al. Identification of the long non-coding RNA H19 in plasma as a novel biomarker for diagnosis of gastric cancer. Sci Rep2015; 5: 11516.
26.
FaticaABozzoniI.Long non-coding RNAs: new players in cell differentiation and development. Nat Rev Genet2014; 15: 7–21.
27.
PengYQiuLXuD, et al. M4IDP, a zoledronic acid derivative, induces G1 arrest, apoptosis and autophagy in HCT116 colon carcinoma cells via blocking PI3K/Akt/mTOR pathway. Life Sci2017; 185: 63–72.
28.
SlomovitzBMColemanRL.The PI3K/AKT/mTOR pathway as a therapeutic target in endometrial cancer. Clin Cancer Res2012; 18: 5856–5864.
29.
SunXPDongXLinL, et al. Up-regulation of survivin by AKT and hypoxia-inducible factor 1α contributes to cisplatin resistance in gastric cancer. FEBS J2014; 281: 115–128.
30.
Heras-SandovalDPerez-RojasJMHernandez-DamianJ, et al. The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration. Cell Signal2014; 26: 2694–2701.
31.
NixonRA.The role of autophagy in neurodegenerative disease. Nat Med2013; 19: 983–997.
32.
CaoYLuoYZouJ, et al. Autophagy and its role in gastric cancer. Clin Chim Acta2019; 489: 10–20.
33.
LeeHJVenkatarame Gowda SaralammaVKimSM, et al. Pectolinarigenin induced cell cycle arrest, autophagy, and apoptosis in gastric cancer cell via PI3K/AKT/mTOR signaling pathway. Nutrients2018; 10: pii: E1043.
34.
ChoiJHChoYSKoYH, et al. Absence of autophagy-related proteins expression is associated with poor prognosis in patients with colorectal adenocarcinoma. Gastroenterol Res Pract2014; 2014: 179586.
35.
HeYZhaoXSubahanNR, et al. The prognostic value of autophagy-related markers beclin-1 and microtubule-associated protein light chain 3B in cancers: a systematic review and meta-analysis. Tumour Biol2014; 35: 7317–7326.
36.
YuSLiGWangZ, et al. Low expression of MAP1LC3B, associated with low Beclin-1, predicts lymph node metastasis and poor prognosis of gastric cancer. Tumour Biol2016; 37: 15007–15017.
37.
LiWYLiQJingL, et al. P57-mediated autophagy promotes the efficacy of EGFR inhibitors in hepatocellular carcinoma. Liver Int2019; 39: 147–157.
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