Concepts of tissue damage from sepsis are rooted in the works of Pasteur regarding colonization by microorganisms, and Lister’s observation of avoiding suppuration by their exclusion. The reactive inflammation has been considered a beneficial defence mechanism. A more complex biology is now unfolding of pathogenic mechanisms with toxins produced by the organisms now being placed in a broad category of virulence factors. Neutrophils are key cells in providing innate immunity and their trafficking to sites of infection results in entry to the extracellular space where they attack pathogens by release of the contents of neutrophil granules and neutrophil extracellular traps. There is now considerable evidence that much of the tissue damage in infection is due to excessive host innate immunological reaction; a hyperinflammatory response, whether localized or systemic. In addition to traditional surgical methods of drainage and decompression there is now a focus on dilution of inflammatory mediators. This emerging knowledge can potentially alter the way we approach hand infections.
Ahmad-MansourNLoubetPPougetC, et al.
Staphylococcus aureus toxins: an update on their pathogenic properties and potential treatments. Toxins (Basel). 2021,
13: 677.
2.
AloufJEMüller-AloufH.Staphylococcal and streptococcal superantigens: molecular, biological and clinical aspects. Int J Med Microbiol. 2003,
292: 429–40.
3.
BerryKAVerhoefMTALeonardACCoxG.Staphylococcus aureus adhesion to the host. Ann NY Acad Sci. 2022,
1515: 75–96.
BunnellS.Surgery of the hand. Infections of the Hand. 2nd Edn.Philadelphia,
Lippincott, 1948, pp. 720–69.
6.
BruunTRathEMadsenMB, et al, INFECT Study Group.
Risk factors and predictors of mortality in streptococcal necrotizing soft-tissue infections: a multicenter prospective study. Clin Infect Dis. 2021,
72: 293–300.
7.
CarterSJBurmanSOMersheimerWL.Treatment of digital tenosynovitis by irrigation with peroxide and oxytetracycline: review of nine cases. Ann Surg. 1966,
163: 645–50.
8.
ChenZZhangHQuM, et al.
Review: the emerging role of neutrophil extracellular traps in sepsis and sepsis-associated thrombosis. Front Cell Infect Microbiol. 2021,
11: 653228.
9.
DenzerLSchrotenHSchwerkC.From gene to protein-how bacterial virulence factors manipulate host gene expression during infection. Int J Mol Sci. 2020,
21: 3730.
10.
DeplancheMMouhaliNNguyenMT, et al.
Staphylococcus aureus induces DNA damage in host cell. Sci Rep. 2019,
22: 7694.
11.
FajgenbaumDCJuneCH.Cytokine storm. N Engl J Med. 2020,
383: 2255–73.
12.
FilepJG.Targeting neutrophils for promoting the resolution of inflammation. Front Immunol. 2022,
13: 866747.
13.
FilippiMD.Neutrophil transendothelial migration: updates and new perspectives. Blood. 2019,
133: 2149–58.
14.
FischettiVA. M protein and other surface proteins on Streptococcus pyogenes. 2022 In: Ferretti JJ, Stevens DL, Fischetti VA (Eds.) Streptococcus pyogenes: basic biology to clinical manifestations, 2nd Edn. Oklahoma City (OK), University of Oklahoma Health Sciences Center, 2022.
15.
GiladiAMMalaySChungKC.A systematic review of the management of acute pyogenic flexor tenosynovitis. J Hand Surg Eur. 2015,
40: 720–8.
16.
GhoshP.Variation, indispensability, and masking in the M protein. Trends Microbiol. 2018,
26: 132–44.
17.
GordonA.A treatise on the epidemic puerperal fever of Aberdeen, 1795London,
Robinson.
18.
GuerraFEBorgognaTRPatelDMSwardEWVoyichJM.Epic immune battles of history: neutrophils vs. Staphylococcus aureus. Front Cell Infect Microbiol. 2017,
30: 286.
19.
HansenMBRasmussenLSSvenssonM. INFECT study group.
Association between cytokine response, the LRINEC score and outcome in patients with necrotising soft tissue infection: a multicentre, prospective study. Sci Rep. 2017,
8: 42179.
20.
HarrisPANanchahalJ.Closed continuous irrigation in the treatment of hand infections. J Hand Surg Br. 1999,
24: 328–33.
21.
HawkAJ.ArtiFacts: fighting wartime wound infections with the Carrel-Dakin method. Clin Orthop Relat Res. 2019,
477: 2651–2.
22.
HertzénEJohanssonLKansalR, et al.
Intracellular Streptococcus pyogenes in human macrophages display an altered gene expression profile. PLoS One. 2012,
7: 35218.
23.
HiltEEFerrieriP.Next generation and other sequencing technologies in diagnostic microbiology and infectious diseases. Genes (Basel). 2022,
3: 1566.
24.
HolmesOW.The contagiousness of puerperal fever. Ebook of Medical Essays. Gutenberg Licence. 1843.
25.
JahnKKohlerTPSwiatekLSWiebeSHammerschmidtS.Platelets, bacterial adhesins and the pneumococcus. Cells. 2022,
25: 1121.
26.
JutilaMABergELKishimotoTK, et al.
Inflammation-induced endothelial cell adhesion to lymphocytes, neutrophils, and monocytes. Role of homing receptors and other adhesion molecules. Transplantation. 1989,
48: 727–31.
27.
KanavelA B.Infections of the hand, 5th Edn.
London, Bailliere,
Tindall and Cox, 1925.
KlemmPSchembriMA.Bacterial adhesins: function and structure. Int J Med Microbiol. 2000,
290: 27–35.
30.
KotbMNorrby-TeglundAMcGeerA, et al.
An immunogenetic and molecular basis for differences in outcomes of invasive group A streptococcal infections. Nat Med. 2002,
8: 1398–404.
31.
LeitãoJH.Microbial virulence factors. Int J Mol Sci. 2020,
27: 5320.
32.
ListerJ.On a new method of treating compound fracture, abscess etc. with observations on the conditions of suppuration. The Lancet. 1867,
89: 326–9.
33.
ListerJ.An inquiry regarding the parts of the nervous system which regulate the contraction of the arteries. Phil Trans Royal Soc Lon. 1858,
148: 607–28.
34.
LiuZHWuQYXuFZhangXLiaoXB.Biofunction and clinical potential of extracellular vesicles from methicillin-resistant Staphylococcus aureus. Microbiol Res. 2023,
266: 127238.
35.
LourdaMDzidicMHertwigL, et al. Karolinska KI/K COVID-19 Study Group.
High-dimensional profiling reveals phenotypic heterogeneity and disease-specific alterations of granulocytes in COVID-19. Proc Natl Acad Sci USA. 2021,
118: 2109123118.
36.
MalenfantJWaltersAKralovicS, et al.
(1842–1908) and his contributions to our understanding of surgery through anatomy. Clin Anat. 2013,
26: 547–50.
37.
MacEwenW.On the results of antiseptic osteotomy for genu valgum, varum, and other osseous deformities of the lower limb. The Lancet1878,
II: 911.
38.
MaiseyHCDoranKSNizetV.Recent advances in understanding the molecular basis of group B Streptococcus virulence. Expert Rev Mol Med. 2008,
22: e27.
39.
MeleneyFL.Treatise on surgical infections.
New York,
Oxford University Press, 1948.
40.
MeleneyFL.Clinical aspects and treatment of surgical infections.
Philadelphia and London,
Saunders, 1949.
41.
MichonJ.Le phlegmon des gaines [Phlegmon of the tendon sheaths]. Ann Chir. 1974,
28: 277–80 [In French].
42.
NémethTSperandioMMócsaiA.Neutrophils as emerging therapeutic targets. Nat Rev Drug Discov. 2020,
19: 253–75.
43.
NeviaserRJ.Closed tendon sheath irrigation for pyogenic flexor tenosynovitis. J Hand Surg Am. 1978,
3: 462–6.
44.
OthmanASekheriMFilepJG.Roles of neutrophil granule proteins in orchestrating inflammation and immunity. FEBS J. 2022,
289: 3932–53.
45.
PåhlmanLIMörgelinMEckertJ, et al.
Streptococcal M protein: a multipotent and powerful inducer of inflammation. J Immunol. 2006,
15: 1221–8.
46.
PapayannopoulosV.Neutrophil extracellular traps in immunity and disease. Nat Rev Immunol. 2018,
18: 134–47.
47.
PasteurL.Mémoire Sur les corpuscules organisés qui existent dans l'atmosphère. 1862.
Paris,
Mallet-Bachelier.
48.
PatelSMathivananNGoyalA.Bacterial adhesins, the pathogenic weapons to trick host defense arsenal. Biomed Pharmacother. 2017,
93: 763–71.
49.
PitaTFelicianoJRLeitãoJH.Small noncoding regulatory RNAs from pseudomonas aeruginosa and burkholderia cepacia complex. Int J Mol Sci. 2018,
27: 3759.
50.
SchultzBMAcevedoOAKalergisAMBuenoSM.Role of extracellular trap release during bacterial and viral infection. Front Microbiol. 2022,
13: 798853.
51.
SeibKLSrikhantaYNAtackJMJenningsMP.Epigenetic regulation of virulence and immunoevasion by phase-variable restriction-modification systems in bacterial pathogens. Annu Rev Microbiol. 2020,
74: 655–71.
52.
SemmelweisIP, Die Atiologie, der Begriff und die Prophylaxis des Kindbettfiebers (1861) Pest, Wien und Leipzig. Hartleben Verlags-Expedizion.
53.
SiemensNSnällJSvenssonMNorrby-TeglundA.Pathogenic mechanisms of streptococcal necrotizing soft tissue infections. Adv Exp Med Biol. 2020,
1294: 127–50.
54.
TecchioCMichelettiACassatellaMA.Neutrophil-derived cytokines: facts beyond expression. Front Immunol. 2014,
5: 508.
55.
Uribe-QuerolERosalesC.Phagocytosis: our current understanding of a universal biological process. Front Immunol. 2020,
11: 1066.
56.
von Köckritz-BlickwedeMWinstelV.Molecular prerequisites for neutrophil extracellular trap formation and evasion mechanisms of staphylococcus aureus. Front Immunol. 2022,
13: 836278.
WanfordJJHachaniAOdendallC.Reprogramming of cell death pathways by bacterial effectors as a widespread virulence strategy. Infect Immun. 2022,
90: e0061421.
59.
WeaversHMartinP.The cell biology of inflammation: from common traits to remarkable immunological adaptations. J Cell Biol. 2020,
219: e202004003.
60.
WilliamsMRAzcutiaVNewtonGAlcaidePLuscinskasFW.Emerging mechanisms of neutrophil recruitment across endothelium. Trends Immunol. 2011,
32: 461–9.
61.
ZhangHWangYQuM, et al.
Neutrophil, neutrophil extracellular traps and endothelial cell dysfunction in sepsis. Clin Transl Med. 2023,
13: e1170.
62.
ZhuYChenXLiuX.NETosis and neutrophil extracellular traps in COVID-19: immunothrombosis and beyond. Front Immunol. 2022,
13: 838011.
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