Influenza A(H1N1)pdm09 virus infection placed a significant burden on intensive care services in the north of England during winter 2010–11 compared with the influenza outbreak in 2009–10. The clinical characteristics of 160 adult patients requiring mechanical ventilation are described in this paper. Comparisons are made with other reported series. Issues related to patient transfers along with logistical and ethical issues arising from national guidance are also discussed.
ErcoleATaylorBLRhodesAMenonDK. Modelling the impact of an influenza A/H1N1 pandemic on critical care demand from early pathogenicity data: the case for sentinel reporting. Anaesthesia2009;64: 937–41.
2.
MenonDKTaylorBLRidleySA. Modelling the impact of an influenza pandemic on critical care services in England. Anaesthesia2005;60: 952–54.
3.
NicolayNCallaghanMADomeganLM. Epidemiology, clinical characteristics and resource implications of pandemic (H1N1) 2009 in intensive care units in Ireland. Crit Care Resusc2010;12: 255–61.
4.
The ANZIC Influenza Investigators. Critical Care Services and 2009 H1N1 Influenza in Australia and New Zealand. N Engl J Med2009;361: 1925–34.
5.
KumarAZarychanskiRPintoR. critically ill patients with 2009 Influenza A(H1N1) infection in Canada. JAMA2009;302: 1872–79.
6.
The ANZIC Influenza Investigators. Critical care services and the H1N1 (2009) influenza epidemic in Australia and New Zealand in 2010: the impact of the second winter epidemic. Crit Care2011;15: R143.
7.
PresanisAMDe AngelisDHagyA. The severity of pandemic H1N1 influenza in the United States, from April to July 2009: A Bayesian analysis. PLoS Med2009;6: e1000207. doi:10.1371/journal.pmed.1000207.
8.
JainSKamimotoLBramleyAM. Hospitalized patients with 2009 H1N1 influenza in the United States, April—June 2009. N Engl J Med2009;361: 1935–44.
9.
EstenssoroERiosFGApezteguiraC. Pandemic 2009 Influenza A in Argentina – A study of 337 patients on mechanical ventilation. Am J Respir Crit Care Med2010;182: 41–48.
10.
RowanKMHarrisonDAWalshTS. The Swine Flu Triage (SwiFT) study: development and ongoing refinement of a triage tool to provide regular information to guide immediate policy and practice for the use of critical care services during the H1N1 swine influenza pandemic. Health Technol Assess2010;14: 335–492.
11.
BewickTMylesPGreenwoodS. Clinical and laboratory features distinguishing pandemic H1N1 influenza-related pneumonia from interpandemic community-acquired pneumonia in adults. Thorax2011;66: 247–52.
12.
Nguyen-Van-TamJSOpenshawPJMHashimA. Risk factors for hospitalisation and poor outcome with pandemic A/H1N1 influenza: United Kingdom first wave (May-September 2009). Thorax2010;65: 645–51.
13.
North of England Critical Care Network homepage. Available from: http://www.noeccn.org.uk/ accessed 30th December 2011.
MillerEHoschlerKHardelidP. Incidence of 2009 pandemic influenza A H1N1 infection in England: a cross-sectional serological study. Lancet2010;375: 1100–08.
The Australia and New Zealand Extracorporeal Membrane Oxygenation (ANZ ECMO) Influenza Investigators. Extracorporeal Membrane Oxygenation for 2009 Influenza A(H1N1) Acute Respiratory Distress Syndrome. JAMA2009;302: 1888–95.
WinterB. The refractory hypoxaemia guideline. JICS2011;12: 8.
23.
KaarlolaATallgrenMPettiläV. Long-term survival, quality of life, and quality-adjusted life-years among critically ill elderly patients. Crit Care Med2006;34: 2120–26.
24.
SacanellaEPérez-CastejónJMNicolásJM. Mortality in healthy elderly patients after ICU admission. Int Care Med2009;35: 550–55.
25.
HampshirePAWelchCAMcCrossanLA. Admission factors associated with hospital mortality in patients with haematological malignancy admitted to UK adult, general critical care units: a secondary analysis of the ICNARC Case Mix Programme Database. Crit Care2009;13: R137 (doi:10.1186/cc8016).
26.
MullerMPMcGeerAJHassanK. Evaluation of pneumonia severity and acute physiology ccores to predict ICU admission and mortality in patients hospitalized for influenza. PLoS ONE2010. 5 (3):e9563. doi:10.1371/journal.pone.0009563.
27.
HubmayrRDFarmerJC. Should we ‘rescue’ patients with 2009 Influenza A(H1N1) and lung injury from conventional mechanical ventilation?Chest2010;137: 745–47.