Metabolic alkalosis is a common acid-base abnormality in hospitalised patients, though not frequently life-threatening. We present a case of severe metabolic alkalosis complicating colorectal surgery, which necessitated treatment with intravenous hydrochloric acid. The pathophysiology and treatment of severe metabolic alkalosis are reviewed, with an emphasis on the risks and benefits of hydrochloric acid use.
RenaudCJNgWPK. Conventional bicarbonate haemodialysis in postgastrocystoplasty metabolic alkalosis. Singapore Med J2008;49: 121–22.
7.
JavaheriSNardellEA. Severe metabolic alkalosis: a case report. Br Med J1981;283: 1016–17.
8.
MazurJEDevlinJWPetersMJ. Single versus multiple doses of acetazolamide for metabolic alkalosis in critically ill medical patients: a randomized, double-blind trial. Crit Care Med1999;27: 1257–61.
9.
WarrenSESwerdlinARSteinbergSM. Treatment of alkalosis with ammonium chloride: a case report. Clin Pharmacol Ther1979;25 (5 pt 1):624–27.
10.
HixsonRChristmasD. Use of omeprazole in life-threatening metabolic alkalosis. Intensive Care Med1999;25: 1201.
11.
KirschBMSunder-PlassmannGSchwarzC. Metabolic alkalosis in a haemodialysis patient-successful treatment with a proton pump inhibitor. Clin Nephrol2006;66: 391–94.
12.
GerhardtREKoetheJDGlickmanJD. Acid dialysate correction of metabolic alkalosis in renal failure. Am J Kidney Dis1995;25: 343–45.
13.
AyusJCOliveroJJAdroquéHJ. Alkalemia associated with renal failure. Correction by hemodialysis with low-bicarbonate dialysate. Arch Intern Med1980;140: 513–55.
14.
HsuSCWangMCLiuHL. Extreme metabolic alkalosis treated with normal bicarbonate hemodialysis. Am J Kidney Dis2001;37: e31.
15.
ElkingtonJ.RDanowskiT.S. The Body Fluids. London: Bailliere, Tindall Cox. 1955: 536.
16.
BrimioulleSVincentJLDufayeP. Hydrochloric acid infusion for treatment of metabolic alkalosis: effects on acid-base balance and oxygenation. Crit Care Med1985;13: 738–42.
17.
BrimioulleSKahnRJ. Effects of metabolic alkalosis on pulmonary gas exchange. Am Rev Respir Dis1990;141 (5 Pt 1):1185–89.
18.
WorthleyLI. The rational use of IV hydrochloric acid in the treatment of metabolic alkalosis. Br J Anaesth1977;49: 811–17.
19.
KwunKBBoucheritTWongJ. Treatment of metabolic alkalosis with intravenous infusion of concentrated hydrochloric acid. Am J Surg1983;146: 328–30.
20.
KopelRFDurbinCGJr. Pulmonary artery catheter deterioration during hydrochloric acid infusion for the treatment of metabolic alkalosis. Crit Care Med1989;17: 688–89.
21.
BuchananIBCampbellBTPeckMD. Chest wall necrosis and death secondary to hydrochloric acid infusion for metabolic alkalosis. South Med J2005;98: 822–24.
22.
JankauskasSJGurselEAntonenkoDR. Chest wall necrosis secondary to hydrochloric acid use in the treatment of metabolic alkalosis. Crit Care Med1989;17: 963–64.
23.
GleißJDüpreeHJLewejohannJC. Sudden cardiac failure following treatment of metabolic alkalosis with hydrochloric acid. Crit Care1999;3(Suppl 1):P122.