The oxidative hypothesis of atherogenesis suggests that an important event in the development of atherosclerotic lesions is the oxidation of lipids contained in low-density lipoprotein (LDL). This hypothesis is supported by a number of in-vitro and in-vivo studies demonstrating the proatherogenic properties of oxidized LDL, the occurrence of oxidatively modified LDL in atherosclerotic lesions and the reduction of atherosclerotic events by antioxidants.
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13.
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HazellLJvan den BergJJStockerR: Oxidation of low-density lipoprotein by hypochlorite causes aggregation that is mediated by modification of lysine residues rather than lipid oxidationBiochem J1994, 302:297–304.
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HazellLJArnoldLFlowersDWägGMalleEStockerR: Presence of hypochlorite-modified proteins in human atherosclerotic lesionsJ Clin Invest1996, 97:1535–1544. Thisstudy provides the first in-vivo evidence that hypochlorite plays a role in atherosclerosis.
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32.
LynchSMFreiB: Reduction of copper, but not iron by human low density lipoprotein (LDL). Implications for metal ion-dependent oxidative modification of LDLJ Biol Chem1995, 270:5158–5163. Thisstudy offers a new possibility, namely the reductive activation of copper by LDL; a method by which copper could account for the initiation of LDL oxidation.
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