In this paper, we reported a patient with a hemispheric glioblastoma extending into the lateral thalamus and the posterior limb of the internal capsule. The waking electroencephalogram showed spindle activity on the side ipsilateral to the tumor. Based on the topography of the tumor in our patient, we speculate that a disruption of the synaptic pathways within the thalamus-cortex-thalamus circuit was primarily involved in the pathogenesis of abnormal spindling.
GibbsF.A., and GibbsE.L., Atlas of Electroencephalography, Vol. 3, Addison-Wesley, Reading, Mass., p. 149, 1964.
2.
KlassD.W., and DalyD.D., Electroencephalography in patients with brain tumor, Med. Clin. North Am., 44:1041–1051, 1960.
3.
Fischer-WilliamsM., Brain tumors and other space-occupying lesions, In NiedermeyerE., and Lopes da SilvaF., (eds): Electroencephalography: Basic Principles, Clinical Applications and Related Fields, Baltimore-Munich, Urban and Schwarzenberg, pp. 197–219, 1982.
4.
HiroseG., LombrosoC.T., and Eisen-BergH., Thalamic tumors in childhood: Clinical, laboratory and therapeutic considerations, Arch. Neurol., 32:740–744, 1975.
5.
KannoO., HosakaH., and YamaguchiT., Dissociation of sleep stages between the two hemispheres in a case with unilateral thalamic tumor, Folia Psychiatr. Neurol. Jpn., 31:69–75, 1977.
6.
GloorP., BallG., and SchaulN., Brain lesions that produce delta waves in the EEG, Neurology, 27:326–333, 1977.
7.
AndersonP., and AndersonS.A., Physiological mechanisms of the alpha waves, In KellawayP., and PetersonS., (eds): Clinical Electroencephalography of Children, New York, Grune and Stratton, pp. 30–48, 1968.
8.
SteriadeM., WyzinskiP., and OaksonG., Activities in synaptic pathways between the motor cortex and ventrolateral thalamus underlying EEG spindle wave, Int. J. Neurol., 8:211–229, 1971.
9.
EchlinF.A., ArnettV., and ZollJ., Paroxysmal high voltage discharges from isolated and partially isolated human and animal cerebral cortex, Electroenceph. Clin. Neuro-physiol., 4:147–164, 1952.
10.
HenryC.E., and ScovilleW.B., Suppression-burst activity from isolated cerebral cortex in man, Electroenceph. Clin. Neurophysiol., 4:1–22, 1952.