The aim of this review was to examine the association between diabetic peripheral neuropathy (DPN) and deficiency of fat-soluble vitamins A, D, and E. Vitamins A, D, and E are involved in crucial neuroprotective mechanisms through the regulation of gene expression and antioxidant activity. Vitamin A appears to actively regulate the expression of nerve growth factor (NGF), essential for the development, survival, and regeneration of peripheral neurons. Vitamin D exhibits immunomodulatory effects, reduces the production of pro-inflammatory cytokines, and enhances neuroplasticity. Similarly, vitamin E, through its potent antioxidant action, minimises damage by reactive oxygen species (ROS), which are responsible for demyelinating lesions. Vitamin supplementation studies have shown a potential symptom improvement or reversal. These findings underline the necessity for early detection and correction of vitamin deficiencies as an integral component of a comprehensive strategy for the prevention and management of DPN.
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