Diabetic neuropathy is a common complication of diabetes; yet its pathophysiology is still incompletely understood and until today, there is no specific treatment against it. In the two 2023 large congresses on diabetes (American Diabetes Association, ADA, European Association for the Study of Diabetes, EASD), several high-level studies have been presented. They have attempted to delineate the pathophysiology of DN, the characteristics of affected patients, and future potential treatments. We herein review the presented studies on diabetic neuropathy at these diabetes congresses and discuss the needs for future research on this topic.
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ÅkerströmTCAAndreasenLNishimuraEYorekMA. Degludec-Like insulin analog improves peripheral neuropathy more than control insulin independent of glycemic control in a rat model of type 2 diabetes. Diabetes. 2023;72(Supplement_1):106-OR.
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JaworskiTJaniszewskiMBudaP, et al.Preclinical efficacy of the novel GPR40 agonist CPL207-280 in neuropathy. Diabetologia. 2023;66(Suppl 1):S202.
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FuYWuLYangYI, et al.Association of silent myocardial infarction with cardiac autonomic neuropathy among asymptomatic patients with type 2 diabetes. Diabetes. 2023;72(Supplement_1):323-OR.
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FleischerJGunaratnamSVGHuangY, et al.Cardiovascular autonomic function in long COVID-19 individuals with and without diabetes. Diabetes. 2023;72(Supplement_1):487-P.
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Pop-BusuiRPatelASangCN, et al.LX9211, An orally-administered, non-opioid, aak1 inhibitor for painful diabetic peripheral neuropathy—results from a randomized, double-blind, placebo-controlled, parallel-group, multicenter study. Diabetes. 2023;72(Supplement_1):103-OR.
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TahraniAMakhdomEMaherA, et al.The impact of obstructive sleep apnoea treatment on peripheral neuropathy in patients with type 2 diabetes: Results from a 2-year feasibility rct. Diabetologia. 2023;66(Suppl 1):S18.
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TentolourisNSiafarikasCDubskyM, et al.Demographics and baseline characteristics of patients with Charcot foot: A multi-centre cohort analysis. Diabetologia. 2023;66(Suppl 1):S16.
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SloanGSelvarajahDAntonATehKWilkinsonID. Preservation of thalamic mitochondrial and neuronal function in painful-diabetic peripheral neuropathy: A multi-modal cerebral imaging study. Diabetologia. 2023;66(Suppl 1):S106.
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KristensenFPBChristensenDHCallaghanBCSorensenHT. Lipid parameters and risk of diabetic polyneuropathy in type 2 diabetes: A Danish cohort study. Diabetologia. 2023;66(Suppl 1):S106-S107.
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MizrakHKufaishiHHecquetS, et al.Prevalence of diabetic neuropathies in individuals with type 1 and type 2 diabetes in a tertiary outpatient clinic: The DANES cohort study. Diabetologia. 2023;66(Suppl 1):S107-S108.
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EleftheriadouARileyDAustinPHernandezGAlamU. Risk of diabetic microvascular complications, heart failure, hospitalisation and all-cause mortality with SGLT2i and GLP1-RA in type 2 diabetes: A real-world data study. Diabetologia. 2023;66(Suppl 1):S74.
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JaiswalMMartinCLBrownMB, et al.Effects of exenatide on measures of diabetic neuropathy in subjects with type 2 diabetes: Results from an 18-month proof-of-concept open-label randomized study. J Diabetes Complications. 2015;29(8):1287-1294.
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PonirakisGAbdul-GhaniMAJayyousiA, et al.Effect of treatment with exenatide and pioglitazone or basal-bolus insulin on diabetic neuropathy: A substudy of the Qatar study. BMJ Open Diabetes Res Care. 2020;8(1):e001420. doi: https://doi.org/10.1136/bmjdrc-2020-001420
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RebelosETentolourisNJudeE. The role of vitamin D in health and disease: A narrative review on the mechanisms linking vitamin D with disease and the effects of supplementation. Drugs. 2023;83(8):665-685. doi: https://doi.org/10.1007/s40265-023-01875-8
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KinesyaESantosoDGde AryaN, et al.Vitamin D as adjuvant therapy for diabetic foot ulcers: Systematic review and meta-analysis approach. Clin Nutr ESPEN. 2023;54:137-143. doi: https://doi.org/10.1016/j.clnesp.2023.01.011
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TentolourisNAlexiadouKMakrilakisKLiatisSJudeEBoultonAJ. Standard and emerging treatment options for diabetic neuropathy. Curr Pharm Des. 2014;20(22):3689-3704. doi: https://doi.org/10.2174/13816128113196660682
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TentolourisAEleftheriadouITentolourisNPapanasN. Highlights from the 82nd ADA scientific sessions and the 58th EASD meeting on diabetic neuropathy. Int J Low Extrem Wounds. 2023:15347346231177569. Online ahead of print. doi: https://doi.org/10.1177/15347346231177569
