Sage Journals: Discover world-class research

Abstract

The relationships between cardiac autonomic neuropathies, diabetic somatic neuropathy, metabolic parameters, general parameters (such as age and duration of illness) and diabetic microangiopathy and macroangiopathy were investigated in 103 patients with non-insulin-dependent diabetes mellitus (NIDDM). Spearman's correlation coefficients were calculated for the comparisons of all the parameters of the neuropathies with all the other parameters. Variables were selected using a stepwise procedure and multiple regression analysis was carried out using these variables. The results of the regression analysis show that diabetic neuropathy is correlated with vascular parameters including blood pressure and pulse-wave velocity, as well as with parameters of sugar and lipid metabolism. The results confirm the diversity of the clinical characteristics of the neuropathies in patients with NIDDM and confirm that these neuropathies do not always occur in parallel.

Keywords

Cardiac autonomic neuropathy Diabetic somatic neuropathy Non-insulin-dependent diabetes mellitus

Get full access to this article

View all access options for this article.

References

Nathan

: Long-term complications of diabetes mellitus. N Engl J Med 1993; 328: 1676–1685

Okada

Ishii

Tanokuchi

: Relationship between cardiosympathetic neuropathy and diabetic somatic neuropathy in patients with NIDDM. J Int Med Res 1995; 23: 228–233

Okada

Tanokuchi

Higuchi

: Cardiosympathetic neuropathy is independent of cardioparasympathetic neuropathy in patients with non-insulin dependent diabetes mellitus. J Int Med Res 1995; 23: 364–368

Okada

Ichiki

Tanokuchi

: Determination of a cut-off point between treatable and untreatable ranges of nephropathy estimated from the urinary albumin index (UAI) in non-insulin dependent diabetes mellitus (NIDDM). In: Recent Trends of Diabetes Mellitus in East Asia ( Mimura

Zhisheng

, eds). Amsterdam: Elsevier Science Publishers, 1990; pp 239–242.

Okada

Tanokuchi

Ichiki

: Significance of urinary albumin index in the urine collected arbitrarily in the morning. Acta Med Okayama 1992; 46: 165–168

WHO Study Group of Diabetes Mellitus: Diabetes Mellitus. Report No. 727. WHO Technical Report Series , Geneva: WHO, 1985.

Sisson

Shapiro

Mayer

: Metaiodobenzyl-guanidine to map scintigraphically the adrenergic nervous system in man. J Nucl Med 1987; 28: 1625–1636.

Sisson

Wieland

Sherman

: Metaiodobenzyl-guanidine as index of the adrenergic nervous system integrity and function. J Nucl Med 1987; 28: 1620–1624.

Ewing

Martyn

Young

: The value of cardiovascular autonomic function tests: 10 years experience in diabetes. Diabetes Care 1985; 8: 491–498.

10.

Richmond

: Preparation and properties of a cholesterol oxidase from Nocardia sp. and its application to the enzymatic assay of total cholesterol in serum. Clin Chem 1973; 19: 1350–1356.

11.

Fossati

Prencipe

: Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide. Clin Chem 1982; 28: 2077–2080.

12.

Burstein

Scholnick

Morfin

: Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions. J Lipid Res 1970; 11: 583–595.

13.

Noma

Hata

Goto

: Quantitation of serum apolipoprotein A-I, A-II, B, C-II, C-III and E in healthy Japanese by turbidimetric immunoassay: reference values, and age- and sex-related differences. Clinica Chemica Acta 1991; 199: 147–158.

Diversity of the Neuropathies in Patients with Non-Insulin-Dependent Diabetes Mellitus

Abstract

Keywords

Get full access to this article

References