The efficacy of photodynamic therapy for the treatment of a large number of skin diseases, in particular non-malignant skin cancer, has been reported by a number of studies. It has been demonstrated to be particularly beneficial for large or multiple lesions, especially where good cosmesis is required. However for PDT to become established in routine clinical practice further comparative multi-center studies with currently accepted standard techniques are required.
AckroydR., KeltyC., BrownN., ReedM.The History of Photodetection and Photodynamic Therapy. Photochem. Photobiol.74, 656–669 (2000).
2.
HewettJ., NadeauV., FergusonJ., MoseleyH.The Application of a Compact Multispectral Imaging System with Integrated Excitation Source to In Vivo Monitoring of Fluorescence During Topical Photodynamic Therapy of Superficial Skin Cancers. Photochem. Photobiol.73, 278 (2001).
3.
PapworthW. A., MitchellW. L., SeversonD., PapsaP. M., DoironD. R.High-powered Dye Laser for Photodynamic Therapy. SPIE1881, 189–194 (1993).
4.
MortonC. A., WhitehurstC., MoseleyH.Development of an Alternative Light Source to Lasers for Photodynamic Therapy: Clinical Evaluation in the Treatment of Pre-malignant Non-melanoma Skin Cancer. Lasers Med Sci.10, 165–171 (1995).
5.
WhitehurstC., ByrneK., MooreJ. V.Development of an Alternative Light Source to Lasers for Photodynamic Therapy, 1: Comparative In Vitro Dose Response Characteristics. Lasers Med Sci.8, 259–267 (1993).
6.
FritschC., StegeH., SaalmannG.Green Light is Effective and Less Painful Than Red Light in Photodynamic Therapy of Facial Solar Keratoses. Photoderm. Photoimmunol. Photomed.13, 181–5 (1997).
7.
MortonC. A., WhitehurstC., MooreJ. V., MacKieR. M.Comparison of Red and Green Light in the Treatment of Bowen's Disease by Photodynamic Therapy. Br. J. Dermatol.143, 767–772 (2000).
8.
KennedyJ. C., PottierR. H., ProssD. C.Photodynamic Therapy with Endogenous Protoporphyrin IX: Basic Principles and Present Clinical Experience. J. Photochem. Photobiol. B.6, 143–148 (1990).
9.
CairnduffF., StringerM. R., HudsonE. J.Superficial Photodynamic Therapy with Topical 5-aminolaevulinic Acid for Superficial Primary and Secondary Skin Cancer. Br. J. Cancer.69, 605–608 (1994).
10.
SvanbergK., AndersonT., KillanderD.Photodynamic Therapy of Nonmelanoma Malignant Tumors of the Skin using Topical 5-aminolaevulinic Acid Sensitisation and Laser Irradiation. Br. J. Dermatol.130, 743–751 (1994).
11.
MortonC. A.The Emerging Role of 5-ALA PDT in Dermatology: Is PDT Superior to Standard Treatments?J. Dermatol. Treat.13, 25–29 (2002).
12.
KalkaK., MerkH., MukhtarH.Photodynamic Therapy in Dermatology. J. Am. Acad. Dermatol.42, 389–413 (2000).
13.
WennbergA. M., LindholmL. E., IpstenM., LarkoO.Treatment of Superficial Basal Cell Carcinomas Using Topically Applied Delta Aminolaevulinic Acid and a Filtered Xenon Lamp. Arch. Dermatol. Res.288, 561–564 (1996).
14.
KerwaH. A., Yong-GeeS. A., SeedP. T.A Randomized Paired Comparison of Photodynamic Therapy and Topical 5-fluouracil in the Treatment of Actinic Keratoses. J. Am. Acad. Dermatol.41, 414–8 (1999).
15.
SziemesR. M., KarrerS., SauerwaldA., LandthalerM.Photodynamic Therapy with Topical Application of 5-aminolaevunic Acid in the Treatment of Actinic Keratoses; An Initial Clinical Study. Dermatology192, 246–251 (1996).
16.
JeffesE. W., McCulloughJ. L., WeinsteinG. D.Photodynamic Therapy of Actinic Keratoses with Topical 5-aminolaevunic Acid. Arch. Dermatol.133, 727–32 (1997).
17.
Fink-PuchesR., HoferA., SmolleJ.Primary Clinical Response and Long-term Follow-up of Solar Keratoses Treated with Topically Applied 5-aminolaevunic Acid and Irradiation by Different Wavebands of Light. J Photochem. Photobiol. B.41, 145–151 (1997).
18.
SziemesR. M., RadakovicS., Calzavara-PintonP. G.A Prospective Randomized Study Comparing Photodynamic Therapy with Metvix to Cryotherapy in Actinic Keratoses. J. Eur. Acad. Dermatol. Venereol.14, 235 (2000).
19.
FoleyP, FreemanM, VinciulloC.A Comparison of Photodynamic using Metvix with Cryotherapy in Actinic Keratoses. J. Eur. Acad. Dermatol. Venereol.15, 223 (2001).
WolfP., RiegerE., KerlH.Topical Photodynamic Therapy with Endogenous Porphyrins After Application of 5-aminolaevulinic Acid. An Alternative Treatment Modality for Solar Keratoses, Superficial Squamous Cell Carcinomas and Basal Cell Carcinomas?J. Am. Acad. Dermatol.28, 17–21 (1993).
22.
WarloeT., HeyerdahlH., PengQ.Photodynamic Therapy with 5-aminolaevunic Acid Induced Porphyrins and Skin Penetration Enhancer for Basal Cell Carcinoma. SPIE2371, 226–235 (1994).
23.
ThissenM. R., SchroeterC. A., NeumannH. A.Photodynamic Therapy with Delta-aminolaevulinic Acid for Nodular Basal Cell Carcinomas Using a Prior Debulking Technique. Br. J. Dermatol.142, 338–9 (2000).
24.
WangI., BendsoeN., KlintebergC. A. F.Photodynamic Therapy vs. Cryosurgery of Basal Cell Carcinomas: Results of Phase III Clinical Trial. Br. J. Dermatol.144, 832–840 (2001).
25.
LemanJ. A., MortonC. A., MacKieR. M.Treatment of Superficial Basal Cell Carcinomas with Topical Photodynamic Therapy; Recurrence Rates and Outcome. Br. J. Dermatol.145, 17 (2001).
26.
SolerA. M., WarloeT., BernerA.A Follow-up Study of Recurrence and Cosmesis in Completely Responding Superficial and Nodular Basal Cell Carcinomas Treated by Methyl 5-aminolaevulinate-based Photodynamic Therapy Along with Prior Curettage. Br. J. Dermatol.145, 467–471 (2001).
27.
FritschC., GoerzG., RuzickaT.Photodynamic Therapy in Dermatology. Arch. Dermatol.134, 207–214 (1998).
28.
MortonC. A., WhitehurstC., McCollJ., MooreJ.Photodynamic Therapy for Large or Multiple Patches of Bowen Disease and Basal Cell Carcinoma. Arch. Dermatol.137, 319–324 (2001).
29.
MortonC. A., WhitehurstC., McCollJ. H.Photodynamic Therapy for Basal Cell Carcinoma: Effect of Tumor Thickness and Duration of Photosensitizer Application on Response. Arch. Dermatol.134, 248–249 (1998).
30.
MortonC. A., WhitehurstC., MoseleyH.Comparison of Photodynamic Therapy with Cryotherapy in the Treatment of Bowen's Disease. Br. J. Dermatol.135, 766–771 (1996).
31.
SalimA., MortonC. A.Comparison of Photodynamic Therapy with Topical 5-fluorouracil in Bowen's Disease. Br. J. Dermatol.114, 114 (2000).
32.
TelferN. R., ColverG. B., BowersP. W.Guidelines for the Management of Basal Cell Carcinoma. Br. J. Dermatol.141, 415–423 (1999).
33.
StablesG. I., StringerM. R., RobinsonD. V., AshD. V.Large Patches of Bowen's Disease Treated by Topical Aminolaevulinic Acid Photodynamic Therapy. Br. J. Dermatol.136, 957–960 (1997).
34.
WangI., SvanbergK., AnderssonS. E., BergR., SvanbergS.Photodynamic Therapy of Non-melanoma Skin Malignancies with Topical Delta-aminolaevulinic Acid; Diagnostic Measurements. SPIE2371, 243–252 (1995).
