Awake brain surgery allows for maximal tumor resection, while minimizing postoperative deficits, even when the tumor is located within eloquent brain regions. In the current study, we present the case of a patient who underwent awake craniotomy to remove a space-occupying lesion located at the left (dominant) temporal lobe. During subcortical mapping, electrical stimulation of the inferior longitudinal fasciculus caused severe errors (paralexias) on a semantic odd-word out task but not on other tasks that use different input routes and processes. The cognitive neuropsychological model for single word processing assisted us to associate a specific structure (inferior longitudinal fascicle [ILF]) with a specific cognitive process (i.e., access to the semantic system). Our results highlight the importance of subcortical fascicles in reading and agree with previous studies regarding the critical role of ILF in reading comprehension.
ArringtonC. N.KuleszP. A.JuranekJ.CirinoP. T.FletcherJ. M. (2017). White matter microstructure integrity in relation to reading proficiency☆. Brain and Language, 174, 103–111.
BaldoJ. V.SchwartzS.WilkinsD.DronkersN. F. (2006). Role of frontal versus temporal cortex in verbal fluency as revealed by voxel-based lesion symptom mapping. Journal of the International Neuropsychological Society, 12(6), 896–900.
4.
Chan-SengE.Moritz-GasserS.DuffauH. (2014). Awake mapping for low-grade gliomas involving the left sagittal stratum: Anatomofunctional and surgical considerations. Journal of Neurosurgery, 120(5), 1069–1077.
5.
CheemaK.LantzN.CummineJ. (2018). Exploring the role of subcortical structures in developmental reading impairments: Evidence for subgroups differentiated by caudate activity. NeuroReport, 29(4), 271–279.
6.
DebetteS.MarkusH. S. (2010). The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: Systematic review and meta-analysis. British Medical Journal, 341, Article c3666. https://doi.org/10.1136/bmj.c3666
7.
De WitteE.SatoerD.RobertE.ColleH.VerheyenS.Visch-BrinkE.MariënP. (2015). The Dutch Linguistic Intraoperative Protocol: A valid linguistic approach to awake brain surgery. Brain and Language, 140, 35–48. https://doi.org/10.1016/j.bandl.2014.10.011
8.
De Witt HamerP. C.Gil RoblesS.ZwindermanA. H.DuffauH.BergerM. S. (2012). Impact of intraoperative stimulation brain mapping on glioma surgery outcome: A meta-analysis. Journal of Clinical Oncology, 30, 2559–2565.
9.
DuffauH. (2015). White matter pathways in the human. In HickokG.SmallS. L. (Eds.), Neurobiology of language (pp. 129–137). Academic Press.
10.
DuffauH.GatignolP.MandonnetE.CapelleL.TaillandierL. (2008). Intraoperative subcortical stimulation mapping of language pathways in a consecutive series of 115 patients with Grade II glioma in the left dominant hemisphere. Journal of Neurosurgery, 109(3), 461–471. https://doi.org/10.3171/jns/2008/109/9/0461
11.
EdenG. F.OluladeO. A.EvansT. M.KrafnickA. J.AlkireD. R. (2015). Imaging studies of reading and reading disability. In TogaA. W. (Ed.), Brain mapping: An encyclopedic reference (Vol. 3, pp. 571–578). Academic Press.
12.
EfstratiadouE. A.ChelasE. N.IgnatiouM.ChristakiV.PapathanasiouI.HilariK. (2012). Quality of life after stroke: Evaluation of the Greek SAQOL-39g. Folia Phoniatrica et Logopaedica, 64(4), 179–186.
13.
GaillardR.NaccacheL.PinelP.ClémenceauS.VolleE.HasbounD.DupontS.BaulacM.DehaeneS.AdamC.CohenL. (2006). Direct intracranial, FMRI, and lesion evidence for the causal role of left inferotemporal cortex in reading. Neuron, 50(2), 191–204. https://doi.org/10.1016/j.neuron.2006.03.031
14.
GoodglassH.KaplanE.BarresiB. (2000). Boston diagnostic aphasia examination (3rd ed.). Lippincott Williams & Wilkins.
15.
HerbetG.Moritz-GasserS.LemaitreA. L.AlmairacF.DuffauH. (2018). Functional compensation of the left inferior longitudinal fasciculus for picture naming. Cognitive Neuropsychology, 36(3–4), 140–157.
16.
HilariK.ByngS.LampingD. L.SmithS. C. (2003). Stroke and Aphasia Quality of Life Scale-39 (SAQOL-39): Evaluation of acceptability, reliability, and validity. Stroke, 34, 1944–1950.
17.
Horowitz-KrausT.WangY.PlanteE.HollandS. K. (2014). Involvement of the right hemisphere in reading comprehension: A DTI study. Brain Research, 1582, 34–44.
18.
Jiménez-PeñaM. M.Gil-RoblesS.Cano-AlonsoR.Recio-RodríguezM.Carrascoso-ArranzJ.Ruiz-OcañaC.Martínez-VegaV. (2017). Essential subcortical tracts in language and reading. 3D-tractography for clinical practice and anatomic correlation with intraoperative subcortical electrostimulation. Clinical Neuroradiology, 27(1), 81–89.
19.
KaplanE.GoodglassH.WeintraubS. (1983). Boston naming test. Lea & Febiger.
20.
KonstantopoulosK.VogazianosP.DoskasT. (2016). Normative data of the Montreal cognitive assessment in the Greek population and parkinsonian dementia. Archives of Clinical Neuropsychology, 31(3), 246–253.
21.
MandonnetE.NouetA.GatignolP.CapelleL.DuffauH. (2007). Does the left inferior longitudinal fasciculus play a role in language? A brain stimulation study. Brain, 130(3), 623–629.
22.
MATLAB (Version 9.10.0) [R2021a]. (2021). The MathWorks.
23.
MeyerL.CunitzK.ObleserJ.FriedericiA. D. (2014). Sentence processing and verbal working memory in a white-matter-disconnection patient. Neuropsychologia, 61, 190–196. https://doi.org/10.1016/j.neuropsychologia.2014.06.014
24.
MortonJ.PattersonK. E. (1980). A new attempt at an interpretation, or an attempt at a new interpretation. In ColtheartM.PattersonK. E.MarshallJ. C. (Eds.), Deep dyslexia (pp. 91–118). Routledge & Kegan Paul.
25.
NasreddineZ. S.PhillipsN. A.BédirianV.CharbonneauS.WhiteheadV.CollinI.CummingsJ. L.ChertkowH. (2005). The Montreal Cognitive Assessment, MoCA: A brief screening tool for mild cognitive impairment. Journal of the American Geriatrics Society, 53(4), 695–699.
26.
OjemannG.OjemannJ.LettichE.BergerM. (2008). Cortical language localization in left, dominant hemisphere: An electrical stimulation mapping investigation in 117 patients. Journal of Neurosurgery, 108(2), 411–421.
27.
OldfieldR. C. (1971). The assessment and analysis of handedness: The Edinburgh inventory. Neuropsychologia, 9(1), 97–113.
28.
PapathanasiouI.PapadimitriouD.GavrilouV.MihouA. (2008). Psychometric properties of BDAE in normal adult population: The effect of age and gender. Psychology/Psixologia, 15, 398–410. (In Greek)
29.
PapatzalasC.FountasK.BrotisA.KapsalakiE.PapathanasiouI. (2021). The Greek linguistic assessment for awake brain surgery: Development process and normative data. Clinical Linguistics & Phonetics, 35(5), 458–488. https://doi.org/10.1080/02699206.2020.1792997
30.
PapatzalasC.FountasK.KapsalakiE.PapathanasiouI. (2021). The use of standardized intraoperative language tests in awake craniotomies: A scoping review. Neuropsychology Review, Advance online publication. https://doi.org/10.1007/s11065-021-09492-6
31.
PriceC. J. (2012). A review and synthesis of the first 20 years of PET and fMRI studies of heard speech, spoken language and reading. NeuroImage, 62(2), 816–847.
32.
RofesA.MandonnetE.de AguiarV.RappB.TsapkiniK.MiceliG. (2018). Language processing from the perspective of electrical stimulation mapping. Cognitive Neuropsychology, 36(3–4), 117–139.
RouxF. E.LubranoV.Lauwers-CancesV.TrémouletM.MascottC. R.DémonetJ. F. (2004). Intra-operative mapping of cortical areas involved in reading in mono-and bilingual patients. Brain, 127(8), 1796–1810.
35.
SandakR.MenclW. E.FrostS. J.PughK. R. (2004). The neurobiological basis of skilled and impaired reading: Recent findings and new directions. Scientific Studies of Reading, 8(3), 273–292.
36.
SierpowskaJ.GabarrósA.Fernández-CoelloA.CaminsÀ.CastañerS.JuncadellaM.FrançoisC.Rodríguez-FornellsA. (2019). White-matter pathways and semantic processing: Intrasurgical and lesion-symptom mapping evidence. NeuroImage: Clinical, 22, Article 101704.
37.
SimosP. G.KaselimisD.MouzakiA. (2011). Age, gender, and education effects on vocabulary measures in Greek. Aphasiology, 25(4), 475–491.
38.
Tzourio-MazoyerN.LandeauB.PapathanassiouD.CrivelloF.EtardO.DelcroixN.MazoyerB.JoliotM. (2002). Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. NeuroImage, 15(1), 273–289. https://doi.org/10.1006/nimg.2001.0978
39.
WhitworthA.WebsterJ.HowardD. (2014). A cognitive neuropsychological approach to assessment and intervention in aphasia: A clinician’s guide. Psychology Press.
40.
World Medical Association. (2001). World Medical Association declaration of Helsinki. Ethical principles for medical research involving human subjects. Bulletin of the World Health Organization, 79(4), 373.
41.
ZemmouraI.HerbetG.Moritz-GasserS.DuffauH. (2015). New insights into the neural network mediating reading processes provided by cortico-subcortical electrical mapping. Human Brain Mapping, 36(6), 2215–2230. https://doi.org/10.1002/hbm.22766
